EG17971A - Process for preparing of renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues - Google Patents
Process for preparing of renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residuesInfo
- Publication number
- EG17971A EG17971A EG503/86A EG50386A EG17971A EG 17971 A EG17971 A EG 17971A EG 503/86 A EG503/86 A EG 503/86A EG 50386 A EG50386 A EG 50386A EG 17971 A EG17971 A EG 17971A
- Authority
- EG
- Egypt
- Prior art keywords
- sup
- disubstituted
- amino
- acid residues
- hydroxypentanoic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Pyrrole Compounds (AREA)
- Polyamides (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76416885A | 1985-08-09 | 1985-08-09 | |
US06/858,324 US4729985A (en) | 1985-08-09 | 1986-04-30 | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues |
Publications (1)
Publication Number | Publication Date |
---|---|
EG17971A true EG17971A (en) | 1991-11-30 |
Family
ID=27117410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EG503/86A EG17971A (en) | 1985-08-09 | 1986-08-10 | Process for preparing of renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues |
Country Status (22)
Country | Link |
---|---|
US (1) | US4729985A (fr) |
EP (1) | EP0212903B1 (fr) |
JP (1) | JPS6253952A (fr) |
KR (1) | KR890003603B1 (fr) |
CN (1) | CN86105870A (fr) |
AT (1) | ATE84046T1 (fr) |
AU (1) | AU576970B2 (fr) |
CA (1) | CA1294736C (fr) |
DE (1) | DE3687380T2 (fr) |
DK (1) | DK379186A (fr) |
EG (1) | EG17971A (fr) |
ES (1) | ES2000852A6 (fr) |
FI (1) | FI86192C (fr) |
GR (1) | GR862078B (fr) |
HU (1) | HU207101B (fr) |
IE (1) | IE58524B1 (fr) |
IL (1) | IL79626A0 (fr) |
NO (1) | NO170725C (fr) |
NZ (1) | NZ217127A (fr) |
PH (1) | PH24494A (fr) |
PT (1) | PT83172B (fr) |
YU (1) | YU45355B (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4727060A (en) * | 1984-11-13 | 1988-02-23 | Ciba-Geigy Corporation | Novel 5-amino-4-hydroxyvaleryl derivatives |
DE3538749A1 (de) * | 1985-10-31 | 1987-05-07 | Merck Patent Gmbh | Peptide |
EP0236734A3 (fr) * | 1986-02-07 | 1988-05-11 | Ciba-Geigy Ag | Dérivés d'amino-5-hydroxy-4-valeryl substitués par des groupes contenant du soufre |
DE3626130A1 (de) * | 1986-08-01 | 1988-02-11 | Merck Patent Gmbh | Aminosaeurederivate |
US4681972A (en) * | 1986-09-16 | 1987-07-21 | Warner-Lambert Company | Separation of diastereomers |
DE3789347D1 (de) * | 1986-10-14 | 1994-04-21 | Banyu Pharma Co Ltd | 5-Substituierte Amino-4-hydroxy-pentansäure-Derivate und deren Verwendung. |
US4927565A (en) * | 1986-12-19 | 1990-05-22 | Banyu Pharmaceutical Co., Ltd. | 5-substituted amino-4-hydroxy-pentenoic acid derivatives and their use |
US4758584A (en) * | 1987-02-05 | 1988-07-19 | Ciba-Geigy Corporation | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups |
DE3888031T2 (de) * | 1987-07-01 | 1994-06-09 | Pfizer | Homocyclostatin und Cyclostatin enthaltende Polypeptide als Antihypertensiva. |
US4859654A (en) * | 1987-07-01 | 1989-08-22 | Pfizer Inc. | Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents |
EP0312158A3 (fr) * | 1987-10-13 | 1990-07-25 | Merck & Co. Inc. | Tétrapeptides ayant des composantes d'amides d'acides aminés C-terminales, inhibiteurs de la rénine |
GB8728561D0 (en) * | 1987-12-07 | 1988-01-13 | Glaxo Group Ltd | Chemical compounds |
GB8728560D0 (en) * | 1987-12-07 | 1988-01-13 | Glaxo Group Ltd | Chemical compounds |
ATE107658T1 (de) * | 1988-01-26 | 1994-07-15 | Sankyo Co | Renin inhibierende polypeptide, ihre herstellung und anwendung. |
WO1989007109A1 (fr) * | 1988-02-01 | 1989-08-10 | The Upjohn Company | Peptides inhibiteur de renine avec groupes terminaux polaires |
JPS6486550A (en) * | 1988-08-19 | 1989-03-31 | Seiko Epson Corp | Complementary mos integrated circuit |
US5436339A (en) * | 1991-03-06 | 1995-07-25 | Abbott Laboratories | Process for the preparation of a substituted diaminoalcohol |
US5238935A (en) * | 1991-05-20 | 1993-08-24 | Schering Corporation | N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme A: cholesterol acyl transferase |
US5124337A (en) * | 1991-05-20 | 1992-06-23 | Schering Corporation | N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase |
TW217410B (fr) * | 1992-04-01 | 1993-12-11 | Ciba Geigy | |
MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
EP0702004A2 (fr) * | 1994-09-15 | 1996-03-20 | Ciba-Geigy Ag | Dérivés d'amides d'acide 2,9-diamino- et 2-amino-2-carbamoyl-4-hydroxy-alcanoiques |
EP0716077A1 (fr) * | 1994-12-08 | 1996-06-12 | Ciba-Geigy Ag | Amides d'acides oméga-amino alcanoiques et diamides alcanoiques ayant un substituant aromatique et leur application en tant qu'inhibiteurs de leur rénine |
CA2191924A1 (fr) * | 1995-12-05 | 1997-06-06 | Kevin Felsenstein | Derives de 5-amino-6-cyclohexyl-4-hydroxyhexanamide, inhibiteurs de la production de proteine .beta.-amyloide |
US5703129A (en) * | 1996-09-30 | 1997-12-30 | Bristol-Myers Squibb Company | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production |
EP1265849B1 (fr) | 2000-03-23 | 2006-10-25 | Elan Pharmaceuticals, Inc. | Composes et methodes de traitement de la maladie d'alzheimer |
EP1299349B1 (fr) | 2000-06-30 | 2005-08-24 | Elan Pharmaceuticals, Inc. | Composes pour le traitement de la maladie d'alzheimer |
RU2550691C2 (ru) * | 2009-08-11 | 2015-05-10 | Новартис Аг | Раскрытие циклов лактонов и лактамов |
CN105195868B (zh) * | 2015-11-12 | 2018-05-15 | 上海电气核电设备有限公司 | 一种机器人焊接系统及其焊接方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4163676A (en) * | 1978-04-03 | 1979-08-07 | Blue Cross Laboratories | Ethanol-modified lecithin cookware spray composition |
NO812612L (no) * | 1980-08-06 | 1982-02-08 | Ferring Pharma Ltd | Enzym-inhibitorer. |
US4478826A (en) * | 1981-10-08 | 1984-10-23 | Merck & Co., Inc. | Renin inhibitory peptides |
CA1258748A (fr) * | 1981-10-08 | 1989-08-22 | Daniel F. Veber | Peptides inhibiteurs de la renine |
US4470971A (en) | 1981-10-19 | 1984-09-11 | Merck & Co., Inc. | Renin inhibitory peptides having His13 |
US4397786A (en) | 1981-11-23 | 1983-08-09 | Merck & Co., Inc. | Method of preparing statine and derivatives |
CA1245217A (fr) * | 1981-12-10 | 1988-11-22 | Joshua S. Boger | Peptides inhibiteurs de la renine |
AU573735B2 (en) * | 1983-02-07 | 1988-06-23 | Aktiebolaget Hassle | Peptide analogue enzyme inhibitors |
US4613676A (en) * | 1983-11-23 | 1986-09-23 | Ciba-Geigy Corporation | Substituted 5-amino-4-hydroxyvaleryl derivatives |
DK110285A (da) * | 1984-03-12 | 1985-09-13 | Pfizer | Polypeptider og polypeptidderivater indeholdende statin eller derivater deraf og farmaceutiske praeparater |
US4661473A (en) * | 1984-03-27 | 1987-04-28 | Merck & Co., Inc. | Renin inhibitors containing peptide isosteres |
EP0486478A3 (en) * | 1984-08-06 | 1992-08-12 | The Upjohn Company | Renin-inhibiting peptides |
DE3512128A1 (de) * | 1985-04-03 | 1986-10-09 | Merck Patent Gmbh, 6100 Darmstadt | Peptide |
-
1986
- 1986-04-30 US US06/858,324 patent/US4729985A/en not_active Expired - Fee Related
- 1986-08-04 EP EP86305995A patent/EP0212903B1/fr not_active Expired - Lifetime
- 1986-08-04 DE DE8686305995T patent/DE3687380T2/de not_active Expired - Fee Related
- 1986-08-04 AT AT86305995T patent/ATE84046T1/de not_active IP Right Cessation
- 1986-08-05 IL IL79626A patent/IL79626A0/xx not_active IP Right Cessation
- 1986-08-06 GR GR862078A patent/GR862078B/el unknown
- 1986-08-07 CA CA000515464A patent/CA1294736C/fr not_active Expired - Fee Related
- 1986-08-07 PH PH34110A patent/PH24494A/en unknown
- 1986-08-07 NZ NZ217127A patent/NZ217127A/xx unknown
- 1986-08-08 ES ES8600952A patent/ES2000852A6/es not_active Expired
- 1986-08-08 IE IE214386A patent/IE58524B1/en not_active IP Right Cessation
- 1986-08-08 YU YU1422/86A patent/YU45355B/xx unknown
- 1986-08-08 DK DK379186A patent/DK379186A/da not_active Application Discontinuation
- 1986-08-08 HU HU863517A patent/HU207101B/hu not_active IP Right Cessation
- 1986-08-08 FI FI863250A patent/FI86192C/fi not_active IP Right Cessation
- 1986-08-08 NO NO863202A patent/NO170725C/no unknown
- 1986-08-08 KR KR1019860006535A patent/KR890003603B1/ko not_active IP Right Cessation
- 1986-08-08 AU AU61021/86A patent/AU576970B2/en not_active Ceased
- 1986-08-08 PT PT83172A patent/PT83172B/pt not_active IP Right Cessation
- 1986-08-09 CN CN198686105870A patent/CN86105870A/zh active Pending
- 1986-08-09 JP JP61187653A patent/JPS6253952A/ja active Granted
- 1986-08-10 EG EG503/86A patent/EG17971A/xx active
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