EG14639A - Process for preparing of novel spiro oxazolidindiones useful as aldose reductace inhibitors and as therapeutic agent - Google Patents

Process for preparing of novel spiro oxazolidindiones useful as aldose reductace inhibitors and as therapeutic agent

Info

Publication number
EG14639A
EG14639A EG79509A EG50979A EG14639A EG 14639 A EG14639 A EG 14639A EG 79509 A EG79509 A EG 79509A EG 50979 A EG50979 A EG 50979A EG 14639 A EG14639 A EG 14639A
Authority
EG
Egypt
Prior art keywords
reductace
oxazolidindiones
aldose
inhibitors
preparing
Prior art date
Application number
EG79509A
Other languages
English (en)
Inventor
C Schnur Rodney
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of EG14639A publication Critical patent/EG14639A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Dental Preparations (AREA)
  • Photosensitive Polymer And Photoresist Processing (AREA)
  • Moulding By Coating Moulds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
EG79509A 1978-08-21 1979-08-20 Process for preparing of novel spiro oxazolidindiones useful as aldose reductace inhibitors and as therapeutic agent EG14639A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/935,199 US4200642A (en) 1978-08-21 1978-08-21 Spiro-oxazolidindiones

Publications (1)

Publication Number Publication Date
EG14639A true EG14639A (en) 1985-03-31

Family

ID=25466700

Family Applications (1)

Application Number Title Priority Date Filing Date
EG79509A EG14639A (en) 1978-08-21 1979-08-20 Process for preparing of novel spiro oxazolidindiones useful as aldose reductace inhibitors and as therapeutic agent

Country Status (34)

Country Link
US (1) US4200642A (en17)
JP (4) JPS6011914B2 (en17)
AR (1) AR225614A1 (en17)
AT (1) AT366689B (en17)
AU (1) AU535170B2 (en17)
BE (1) BE878311A (en17)
CA (1) CA1121361A (en17)
CH (1) CH639974A5 (en17)
CS (1) CS208129B2 (en17)
DD (1) DD146602A5 (en17)
DE (2) DE2933441C2 (en17)
DK (1) DK258479A (en17)
EG (1) EG14639A (en17)
ES (1) ES483511A1 (en17)
FI (1) FI65255C (en17)
FR (3) FR2442851A1 (en17)
GB (2) GB2028318B (en17)
GR (1) GR71913B (en17)
HU (1) HU179746B (en17)
IE (1) IE48932B1 (en17)
IL (1) IL58076A (en17)
IN (1) IN152416B (en17)
IT (1) IT1123536B (en17)
LU (1) LU81613A1 (en17)
NL (1) NL7906318A (en17)
NO (1) NO792699L (en17)
NZ (1) NZ191350A (en17)
PH (1) PH18091A (en17)
PL (1) PL130686B1 (en17)
PT (1) PT70086A (en17)
SE (1) SE447116B (en17)
SU (1) SU942597A3 (en17)
YU (1) YU41488B (en17)
ZA (1) ZA794379B (en17)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4329459A (en) * 1980-05-05 1982-05-11 The Upjohn Company Tetrahydrobenzopyran derivatives
US4367234A (en) * 1980-07-28 1983-01-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
GB2080803B (en) * 1980-07-28 1984-01-18 Pfizer Hypoglycemic 5-substituted oxazolidine-2,4-diones
ES515751A0 (es) * 1981-10-13 1983-10-16 Pfizer "un procedimiento por analogia para la preparacion de derivados de espiro-oxindol-oxazolidindiona".
US4540700A (en) * 1982-04-15 1985-09-10 Alcon Laboratories, Inc. Treatment of diabetic complications with certain spiro-imidazolidine-diones
US4464385A (en) * 1982-04-15 1984-08-07 Alcon Laboratories, Inc. Treatment of diabetic complications with hydantoins
US4436745A (en) 1982-04-15 1984-03-13 Alcon Laboratories, Inc. Method of inhibiting aldose reductase activity
US4438272A (en) 1982-04-15 1984-03-20 Alcon Laboratories, Inc. Spiro-(fluoren-9,4'-imidazolidine)-2',5'-diones
ZA832679B (en) * 1982-05-07 1983-12-28 Ici Plc Indoline derivatives
US4430337A (en) 1982-06-23 1984-02-07 Pfizer Inc. Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity
US4556670A (en) * 1982-12-06 1985-12-03 Pfizer Inc. Spiro-3-hetero-azolones for treatment of diabetic complications
US4464380A (en) * 1983-05-25 1984-08-07 Pfizer Inc. Imidazolidinedione derivatives
US4533667A (en) * 1983-05-25 1985-08-06 Pfizer Inc. Imidazolidinedione derivatives
DK277484A (da) * 1983-06-23 1984-12-24 Hoffmann La Roche Thiazolidinderivater
JPS61200991A (ja) * 1985-03-04 1986-09-05 Sanwa Kagaku Kenkyusho:Kk スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤
DE3522791C1 (en) * 1985-06-26 1987-01-02 Ferroplast Gmbh Positioning wall for lagging a cavity to be filled with a hardenable material in mining or tunnelling
US4853410A (en) * 1986-01-17 1989-08-01 Pfizer Inc. Hydroxyacetic acid derivatives for the treatment of diabetic complications
US5039672A (en) * 1990-04-05 1991-08-13 Pfizer Inc. Heterocyclic compounds as aldose reductase inhibitors
US5068332A (en) * 1990-10-12 1991-11-26 American Home Products Corporation Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US5102886A (en) * 1990-10-12 1992-04-07 American Home Products Corporation 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
FR2707981B1 (fr) * 1993-07-20 1995-09-01 Adir Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
WO2000078313A1 (en) 1999-06-18 2000-12-28 Merck & Co., Inc. Arylthiazolidinedione and aryloxazolidinedione derivatives
AU773505B2 (en) 1999-06-18 2004-05-27 Merck & Co., Inc. Arylthiazolidinedione and aryloxazolidinedione derivatives
ITPI20060083A1 (it) * 2006-07-11 2008-01-12 Univ Pisa Derivati 2,2-dimetilcromanici 4-spiro-eterocicilici azotati (a 5 e 6 termini) n-sostituiti quali cardio-protettori nei confronti dell'insulto ischemico
USD775790S1 (en) * 2015-11-18 2017-01-10 Ginger Damon Motorcycle jacket
RU2748513C1 (ru) 2017-12-21 2021-05-26 Эссити Хайджин Энд Хелт Актиеболаг Впитывающее изделие и способ изготовления впитывающего изделия
RU2020123382A (ru) 2017-12-21 2022-01-21 Эссити Хайджин Энд Хелт Актиеболаг Впитывающее изделие и способ изготовления впитывающего изделия

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1204232B (de) * 1959-07-16 1965-11-04 Ncr Co Verfahren zur Herstellung von Derivaten von 3-Alkyl-3'-methyl-spiro[benzoxazolin-2, 2'-(2'H-1'-benzopyran)]
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
CA1088945A (en) * 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents

Also Published As

Publication number Publication date
FR2440950B1 (en17) 1981-06-12
FR2442851A1 (fr) 1980-06-27
PT70086A (en) 1979-09-01
AU5009279A (en) 1980-02-28
IE791592L (en) 1980-02-21
IT1123536B (it) 1986-04-30
DD146602A5 (de) 1981-02-18
FR2440949B1 (en17) 1981-06-12
GB2033904B (en) 1982-08-04
JPS6011915B2 (ja) 1985-03-28
JPS55129288A (en) 1980-10-06
ES483511A1 (es) 1980-09-01
DE2933441C2 (de) 1987-04-23
FR2442851B1 (en17) 1983-06-17
GB2028318B (en) 1982-08-04
GR71913B (en17) 1983-08-16
FI65255B (fi) 1983-12-30
SE7906949L (sv) 1980-02-22
YU41488B (en) 1987-08-31
DE2953954C2 (en17) 1987-12-03
JPS5528996A (en) 1980-02-29
ZA794379B (en) 1980-08-27
PL217881A1 (en17) 1981-01-02
PH18091A (en) 1985-03-20
US4200642A (en) 1980-04-29
DE2933441A1 (de) 1980-02-28
JPS55129280A (en) 1980-10-06
IL58076A0 (en) 1979-12-30
PL130686B1 (en) 1984-08-31
SE447116B (sv) 1986-10-27
IE48932B1 (en) 1985-06-26
NL7906318A (nl) 1980-02-25
SU942597A3 (ru) 1982-07-07
CS208129B2 (en) 1981-08-31
BE878311A (fr) 1980-02-20
JPS5946517B2 (ja) 1984-11-13
AT366689B (de) 1982-04-26
AR225614A1 (es) 1982-04-15
ATA560579A (de) 1981-09-15
HU179746B (en) 1982-12-28
JPS55129279A (en) 1980-10-06
LU81613A1 (fr) 1980-04-21
IT7925182A0 (it) 1979-08-20
FR2440950A1 (fr) 1980-06-06
YU199979A (en) 1983-06-30
GB2028318A (en) 1980-03-05
FR2440949A1 (fr) 1980-06-06
DK258479A (da) 1980-02-22
NZ191350A (en) 1984-04-27
JPS5943954B2 (ja) 1984-10-25
DE2953954A1 (en17) 1982-09-02
GB2033904A (en) 1980-05-29
JPS6011914B2 (ja) 1985-03-28
IN152416B (en17) 1984-01-07
CH639974A5 (fr) 1983-12-15
NO792699L (no) 1980-02-22
FI65255C (fi) 1984-04-10
CA1121361A (en) 1982-04-06
IL58076A (en) 1982-07-30
FI792567A (fi) 1980-02-22
AU535170B2 (en) 1984-03-08

Similar Documents

Publication Publication Date Title
EG14639A (en) Process for preparing of novel spiro oxazolidindiones useful as aldose reductace inhibitors and as therapeutic agent
YU42655B (en) Process for obtaining derivatives of carboxialkyldipeptides
JPS52116492A (en) Alkyloxim derivative of novel 77aminothiazolylacetamide cephalospolanate process for preparing same and medical composition
PT69202A (en) Process for preparing of 9-amino-dibenzopyrans
GR61175B (en) Preparation process of (1-phenyl-2-triazolyl-ethyl)-ether-derivatives and use thereof as fungicides
EG12222A (en) Process for preparing of novel imidazole derivatives and their use as anti-fungal agents
PL233258A1 (en) Process for preparing novel analogs of linkomycin and klinodamycin
SG9484G (en) Unsaturated-thio-derivatives of 7-acetamido-3-cephem-4-carboxylic acid and process for their preparation
EG13280A (en) Process for preparing of novel azolyl ether derivatives and their use as fungicides
EG12936A (en) Process for preparing of thiazolylcinnamic acid nitrilles and their use as pesticides
GB2040283B (en) Process for preparation of urea
IL54392A (en) Process for the preparation of 4-hydroxy-5-alkyl-3-oxo-2h-furans and 2-carbalkoxy-furan derivatives employed as intermediates in the process
ZA796438B (en) Process for preparation of alcohol
EG15085A (en) Process for preparation of spiro-quinolyhydantions derivatives for aldose inhibitors
GR61726B (en) Preparation process of novel isoquinoleine derivatives
GB2001625B (en) Process for preparation of 3-acylamino-4-homoisotwistane
HU178397B (en) Process for preparing substituted derivatives of steroid-spiro-oxazolidione derivatives
YU42987B (en) Process for preparing new derivatives of 1-oxadethiacephalosporin
PL241759A1 (en) Process for preparing novel derivatives of cycloalkanes
DE2963316D1 (en) Process for the preparation of 2-amino-arylenothiazole compounds and their ring n-substituted derivatives
HU179621B (en) Process for preparing carbamete derivatives of mercapto-acyl-hydroxy-l-proline
EG15355A (en) Process for preparing of novel sulfenyls and their use as pesticides
PT71552B (en) Process for preparation of thienamycin and intermediates
EG13847A (en) Process for preparing of integrated ammonia-urea
CS194589B1 (en) Derivatives of 7-ethyl-4-/4-ethylphenyl/-alphanaphthole and process for preparing thereof