EE200400042A - 8/17 heterotsüklilised ühendid ning nende kasutamine D-alanüül-D-alaniini ligaasi inhibiitoritena - Google Patents

8/17 heterotsüklilised ühendid ning nende kasutamine D-alanüül-D-alaniini ligaasi inhibiitoritena

Info

Publication number
EE200400042A
EE200400042A EEP200400042A EEP200400042A EE200400042A EE 200400042 A EE200400042 A EE 200400042A EE P200400042 A EEP200400042 A EE P200400042A EE P200400042 A EEP200400042 A EE P200400042A EE 200400042 A EE200400042 A EE 200400042A
Authority
EE
Estonia
Prior art keywords
alanyl
heterocyclic compounds
ligase inhibitors
alanine ligase
alanine
Prior art date
Application number
EEP200400042A
Other languages
English (en)
Estonian (et)
Inventor
T. Moe Scott
J. Ala Paul
Perola Emanuele
H. Faerman Carlos
J. Clement Jacob
A. Ali Janid
M. Will Paul
A. Marchese Salvatore
S. Magee Andrew
V. Gazzaniga John
Farady Christopher
A. Navia Manuel
R. Connelly Patrick
Original Assignee
Essential Therapeutics, Inc.
Pliva D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Essential Therapeutics, Inc., Pliva D.D. filed Critical Essential Therapeutics, Inc.
Publication of EE200400042A publication Critical patent/EE200400042A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200400042A 2001-06-28 2002-06-28 8/17 heterotsüklilised ühendid ning nende kasutamine D-alanüül-D-alaniini ligaasi inhibiitoritena EE200400042A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30168501P 2001-06-28 2001-06-28
PCT/US2002/020567 WO2003001887A2 (en) 2001-06-28 2002-06-28 Fused pyrimidines as d-alanyl-d-alanine ligase inhibitors

Publications (1)

Publication Number Publication Date
EE200400042A true EE200400042A (et) 2004-10-15

Family

ID=23164426

Family Applications (2)

Application Number Title Priority Date Filing Date
EEP200400042A EE200400042A (et) 2001-06-28 2002-06-28 8/17 heterotsüklilised ühendid ning nende kasutamine D-alanüül-D-alaniini ligaasi inhibiitoritena
EEP200400043A EE200400043A (et) 2001-06-28 2002-06-28 Uudsed heterotsüklilised ühendid kui selektiivsedbakteriaalsed DHFR inhibiitorid ning nende kasutamine

Family Applications After (1)

Application Number Title Priority Date Filing Date
EEP200400043A EE200400043A (et) 2001-06-28 2002-06-28 Uudsed heterotsüklilised ühendid kui selektiivsedbakteriaalsed DHFR inhibiitorid ning nende kasutamine

Country Status (16)

Country Link
US (3) US7345048B2 (cs)
EP (2) EP1411949A4 (cs)
CN (2) CN1547472A (cs)
BG (1) BG108548A (cs)
BR (1) BR0211310A (cs)
CA (2) CA2451800A1 (cs)
CZ (2) CZ200443A3 (cs)
EA (1) EA200400094A1 (cs)
EE (2) EE200400042A (cs)
HU (2) HUP0700061A2 (cs)
IL (2) IL159538A0 (cs)
MX (1) MXPA04000159A (cs)
PL (2) PL374589A1 (cs)
SK (1) SK302004A3 (cs)
WO (2) WO2003001887A2 (cs)
YU (2) YU102303A (cs)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0217703D0 (en) * 2002-07-31 2002-09-11 Univ Liverpool Pharmaceutical composition
EP1812409A1 (en) * 2004-11-09 2007-08-01 F. Hoffmann-Roche AG Aminoquinazolines compounds
CN101243081A (zh) * 2005-07-21 2008-08-13 霍夫曼-拉罗奇有限公司 作为PTP1B抑制剂的吡啶并[2,3-d]嘧啶-2,4-二胺化合物
GB0608822D0 (en) * 2006-05-04 2006-06-14 Chroma Therapeutics Ltd Inhibitors of DHFR
SI22338A (sl) * 2006-08-18 2008-02-29 Univerza V Ljubljani, Fakulteta Za Farmacijo Diazendikarboksamidi kot inhibitorji d-alanil-d-alanin ligaze
TW200831528A (en) 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
CN101084901B (zh) * 2007-06-22 2011-12-21 复旦大学 一种葡萄球菌抑制剂
JP5524084B2 (ja) * 2008-02-01 2014-06-18 武田薬品工業株式会社 Ｈｓｐ９０阻害剤としてのオキシム誘導体
JP2012520745A (ja) * 2009-03-20 2012-09-10 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 医療装置に抗菌活性を付与するための方法
EP2473511A1 (en) * 2009-08-31 2012-07-11 Dow AgroSciences LLC Pteridines and their use as agrochemicals
RS56787B1 (sr) 2015-03-04 2018-04-30 Gilead Sciences Inc Toll-like receptor koji modulira jedinjenja 4,6-diamino-pirido[3,2-d]pirimidina
CN106316966A (zh) * 2015-06-15 2017-01-11 董运勤 医药中间体n-(2-吡嗪甲基)苄胺磷酸盐化合物制备方法
ES2826748T3 (es) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
CA3035346A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. Toll like receptor modulator compounds
KR20200012823A (ko) 2017-02-01 2020-02-05 예일 유니버시티 이뇨제 내성의 치료
MY201934A (en) 2018-01-05 2024-03-25 Novo Nordisk As Methods for treating il-6 mediated inflammation without immunosuppression
EP3917914A1 (en) * 2019-02-01 2021-12-08 Fmc Corporation Diamino-substituted pyridines and pyrimidines as herbicides
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI751516B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
GB2626567A (en) * 2023-01-26 2024-07-31 De Montfort Univ Quinazoline derivatives for use as a medicament

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2949466A (en) * 1958-03-04 1960-08-16 Parke Davis & Co Pyrimidine compounds and means of producing the same
US3134778A (en) * 1963-08-20 1964-05-26 Smith Kline French Lab 2,5,7-triamino-4-phenyl (or thienyl)-pyrimido[4,5-d]pyrimidines
RO56210A2 (cs) 1970-12-28 1974-08-01
US4079056A (en) * 1975-03-31 1978-03-14 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of making pteridine compounds
DE2750288A1 (de) * 1977-11-10 1979-05-17 Thomae Gmbh Dr K Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3445298A1 (de) * 1984-12-12 1986-06-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
WO1992017478A1 (en) 1991-04-08 1992-10-15 Duquesne University Of The Holy Ghost 5-ALKYL-6-[[AMINO]METHYL]PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AND METHODS OF PREPARING AND USING THESE DERIVATIVES
US5547954A (en) 1994-05-26 1996-08-20 Fmc Corporation 2,4-Diamino-5,6-disubstituted-and 5,6,7-trisubstituted-5-deazapteridines as insecticides
ES2207657T3 (es) * 1995-02-27 2004-06-01 F. Hoffmann-La Roche Ag Pirrolderivados de dioxopirrolo.
AU2960599A (en) 1998-03-30 1999-10-18 Akira Karasawa Quinazoline derivatives
JP2000239277A (ja) 1999-02-19 2000-09-05 Kyowa Hakko Kogyo Co Ltd イミダゾキナゾリン誘導体
GB0219893D0 (en) 2002-08-27 2002-10-02 Melacure Therapeutics Ab Pharmaceutically active compounds

Also Published As

Publication number Publication date
CA2451840A1 (en) 2003-01-09
IL159540A0 (en) 2004-06-01
US20080090847A1 (en) 2008-04-17
US7345048B2 (en) 2008-03-18
EP1411949A2 (en) 2004-04-28
WO2003001887A2 (en) 2003-01-09
EP1432713A4 (en) 2005-05-11
YU102503A (sh) 2006-08-17
BR0211310A (pt) 2006-10-31
IL159538A0 (en) 2004-06-01
CN1543465A (zh) 2004-11-03
CZ200443A3 (cs) 2004-08-18
HUP0700040A2 (en) 2007-05-29
HUP0700061A2 (en) 2007-05-02
US20030176436A1 (en) 2003-09-18
CA2451800A1 (en) 2003-01-09
EA200400094A1 (ru) 2005-08-25
YU102303A (sh) 2006-08-17
EP1432713A2 (en) 2004-06-30
WO2003002064A2 (en) 2003-01-09
WO2003002064A3 (en) 2003-10-23
PL374589A1 (en) 2005-10-31
CN1547472A (zh) 2004-11-17
WO2003001887A3 (en) 2003-08-21
CZ200442A3 (cs) 2004-10-13
SK302004A3 (sk) 2005-07-01
US20030181470A1 (en) 2003-09-25
EP1411949A4 (en) 2004-11-24
PL374259A1 (en) 2005-10-03
MXPA04000159A (es) 2005-01-07
EE200400043A (et) 2004-10-15
BG108548A (bg) 2005-05-31

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