EE04349B1 - Aminohappe hüdroksüetüülamino-sulfoonamiidsed retroviirusliku proteaasi inhibiitorid - Google Patents
Aminohappe hüdroksüetüülamino-sulfoonamiidsed retroviirusliku proteaasi inhibiitoridInfo
- Publication number
- EE04349B1 EE04349B1 EE9700201A EE9700201A EE04349B1 EE 04349 B1 EE04349 B1 EE 04349B1 EE 9700201 A EE9700201 A EE 9700201A EE 9700201 A EE9700201 A EE 9700201A EE 04349 B1 EE04349 B1 EE 04349B1
- Authority
- EE
- Estonia
- Prior art keywords
- retroviral
- amino acid
- protease inhibitors
- retroviral protease
- protease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C07K5/06069—Ser-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40228795A | 1995-03-10 | 1995-03-10 | |
US08/474,052 US5756533A (en) | 1995-03-10 | 1995-06-07 | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
PCT/US1996/002684 WO1996028463A1 (fr) | 1995-03-10 | 1996-03-07 | Hydroxyethylamino sulfonamide a aminoacide agissant comme inhibiteurs de proteases retrovirales |
Publications (2)
Publication Number | Publication Date |
---|---|
EE9700201A EE9700201A (et) | 1998-02-16 |
EE04349B1 true EE04349B1 (et) | 2004-08-16 |
Family
ID=23591303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EE9700201A EE04349B1 (et) | 1995-03-10 | 1996-03-07 | Aminohappe hüdroksüetüülamino-sulfoonamiidsed retroviirusliku proteaasi inhibiitorid |
Country Status (23)
Country | Link |
---|---|
US (3) | US5756533A (fr) |
EP (2) | EP0813542B1 (fr) |
JP (1) | JP4091111B2 (fr) |
KR (1) | KR100377855B1 (fr) |
CN (1) | CN1204144C (fr) |
AT (1) | ATE226213T1 (fr) |
AU (1) | AU705268B2 (fr) |
BR (1) | BR9607638A (fr) |
CA (1) | CA2215061A1 (fr) |
CZ (1) | CZ297719B6 (fr) |
DE (1) | DE69624346T2 (fr) |
DK (1) | DK0813542T3 (fr) |
EA (1) | EA000470B1 (fr) |
EE (1) | EE04349B1 (fr) |
ES (1) | ES2187640T3 (fr) |
HU (1) | HUP9801562A3 (fr) |
NO (1) | NO974148L (fr) |
NZ (1) | NZ303861A (fr) |
PL (1) | PL184748B1 (fr) |
PT (1) | PT813542E (fr) |
SK (1) | SK285688B6 (fr) |
UA (1) | UA56130C2 (fr) |
WO (1) | WO1996028463A1 (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040122000A1 (en) | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
US5756533A (en) * | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6140505A (en) * | 1995-03-10 | 2000-10-31 | G. D. Searle & Co. | Synthesis of benzo fused heterocyclic sulfonyl chlorides |
US5776971A (en) * | 1995-03-10 | 1998-07-07 | G.D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
CA2336160C (fr) | 1998-06-23 | 2015-02-17 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Utilisation de composes pour traiter le vih |
WO1999067254A2 (fr) * | 1998-06-23 | 1999-12-29 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Inhibiteurs de protease retrovirale resistant a l'action de plusieurs medicaments et procedes associes |
US6538006B1 (en) | 1998-07-08 | 2003-03-25 | Pharmacia Corporation | Retroviral protease inhibitors |
AR031520A1 (es) * | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
AUPR034000A0 (en) * | 2000-09-25 | 2000-10-19 | Fujisawa Pharmaceutical Co., Ltd. | Aminoalcohol derivatives |
PT1370543E (pt) | 2001-02-14 | 2007-02-28 | Tibotec Pharm Ltd | Inibidores de protease de vih 2-(amino-substituída)-benzotiazol-sulfonamida de largo espectro |
SK288232B6 (sk) * | 2001-04-09 | 2014-11-04 | Tibotec Pharmaceuticals Ltd. | 2-(substituovaný amino)benzoxazolsulfónamidový derivát, jeho aplikácie ako liečiva, farmaceutická kompozícia s jeho obsahom a spôsob in vitro inhibície retrovírusovej replikácie |
DK1387842T3 (da) * | 2001-05-11 | 2009-08-10 | Tibotec Pharm Ltd | Bredspektrede 2-amino-benzoxazolsulfonamid-HIV-protease-inhibitorer |
MXPA04006201A (es) | 2001-12-21 | 2004-12-06 | Tibotec Pharm Ltd | Sulfonamidas que contienen fenilo sustituido con grupos heterociclicos, inhibidores de la proteasa del vih de amplio espectro. |
EP1482864B2 (fr) * | 2002-01-31 | 2010-08-18 | Radi Medical Systems Ab | Endoprothese vasculaire soluble |
US7157489B2 (en) | 2002-03-12 | 2007-01-02 | The Board Of Trustees Of The University Of Illinois | HIV protease inhibitors |
MY142238A (en) * | 2002-03-12 | 2010-11-15 | Tibotec Pharm Ltd | Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors |
AU2003238074B2 (en) * | 2002-05-17 | 2009-04-30 | Tibotec Pharmaceuticals Ltd. | Broadspectrum substituted benzisoxazole sulfonamide HIV protease inhibitors |
OA12893A (en) * | 2002-08-02 | 2006-10-13 | Tibotec Pharm Ltd | Broadspectrum 2-Amino-Benzothiazole Sulfonamide HIV Protease Inhibitors. |
US7199148B2 (en) | 2002-08-14 | 2007-04-03 | Tibotec Pharmaceuticals Ltd | Broadspectrum substituted oxindole sulfonamide HIV protease inhibitors |
US20060128634A1 (en) * | 2002-11-14 | 2006-06-15 | Carini David J | Alpha, alpha-disubstituted benzylglycine derivatives as HIV protease inhibitors |
US6943170B2 (en) * | 2002-11-14 | 2005-09-13 | Bristol-Myers Squibb Company | N-cycloalkylglycines as HIV protease inhibitors |
UA85567C2 (en) | 2003-12-23 | 2009-02-10 | Тиботек Фармасьютикелз Лтд. | Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate |
PT1725566E (pt) | 2003-12-23 | 2009-09-16 | Tibotec Pharm Ltd | Processo para a preparação de (1s,2r)-3-[[(4-aminofenil) sulfonil](isobutil)amino]-1-benzil-2-hidroxipropilcarbamato de (3r,3as,6ar)-hexa-hidrofuro[2,3-b]furan-3-ilo |
CA2559328A1 (fr) | 2004-03-11 | 2005-09-22 | Sequoia Pharmaceuticals, Inc. | Inhibiteurs de la protease retrovirale inhibant la resistance |
US8048871B2 (en) | 2006-08-18 | 2011-11-01 | Sequoia Pharmaceuticals, Inc. | Compositions and methods for inhibiting cytochrome P450 |
CA2707161C (fr) * | 2007-11-28 | 2016-08-16 | Sequoia Pharmaceuticals, Inc. | Compositions et procedes destines a l'inhibition du cytochrome p450 2d6 |
JP2011518188A (ja) * | 2008-04-18 | 2011-06-23 | ユニバーシティ オブ コネチカット | リソソーム調節のための化合物および使用方法 |
WO2011010524A1 (fr) * | 2009-07-24 | 2011-01-27 | 住友精化株式会社 | Procédé de production de chlorures d'alcoxybenzènesulfonyle |
PE20141370A1 (es) | 2011-12-09 | 2014-10-17 | Chiesi Farma Spa | Inhibidores de quinasa |
CN104387299B (zh) * | 2014-10-23 | 2016-08-17 | 凯莱英医药集团(天津)股份有限公司 | 4-氨基-n-[(2r, 3s)-3-氨基-2-羟基-4-苯丁基]-n-异丁基苯磺酰胺的制备方法 |
CN111205206B (zh) * | 2020-02-13 | 2021-10-22 | 中国医学科学院医药生物技术研究所 | 一种包含氨基酸连接链的羰基化合物或其药学上可接受的盐及其制备方法和应用 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
EP0068378B1 (fr) * | 1981-06-26 | 1986-03-05 | Schering Corporation | Imidazo(1,2-a)pyridines et pyrazines, procédés pour leur préparation et composés pharmaceutiques les contenant |
US4634465A (en) * | 1982-07-16 | 1987-01-06 | Ciba-Geigy Corporation | Fused N-phenylsulfonyl-N'-pyrimidinylureas and N-phenylsulfonyl-N'triazinylureas |
DE3377497D1 (en) * | 1982-09-15 | 1988-09-01 | Haessle Ab | Enzyme inhibitors |
US4595407A (en) * | 1982-11-01 | 1986-06-17 | E. I. Du Pont De Nemours And Company | Triazinyl-amino-carbonyl-1,3-benzohetero- or -1,4-benzohetero-sulfonamides |
EP0114993B1 (fr) * | 1982-12-27 | 1990-05-16 | Merck & Co. Inc. | Tripeptides, inhibiteurs de rénine |
US4668770A (en) * | 1982-12-27 | 1987-05-26 | Merck & Co., Inc. | Renin inhibitory tripeptides |
EP0118223A1 (fr) * | 1983-02-07 | 1984-09-12 | Aktiebolaget Hässle | Inhibiteurs d'enzymes |
HU197774B (en) * | 1983-02-16 | 1989-05-29 | Laszlo Paszner | Organic solvent process for the hydrolytic saccharification of vegetable materials of starch type |
JPS59227851A (ja) * | 1983-06-09 | 1984-12-21 | Sankyo Co Ltd | レニン阻害作用を有するペプチド類 |
US4514391A (en) * | 1983-07-21 | 1985-04-30 | E. R. Squibb & Sons, Inc. | Hydroxy substituted peptide compounds |
US4477441A (en) * | 1983-09-14 | 1984-10-16 | Merck & Co., Inc. | Renin inhibitors containing a C-terminal disulfide cycle |
US4645759A (en) * | 1984-06-22 | 1987-02-24 | Abbott Laboratories | Renin inhibiting compounds |
US4616088A (en) * | 1984-10-29 | 1986-10-07 | E. R. Squibb & Sons, Inc. | Amino acid ester and amide renin inhibitor |
US4668769A (en) * | 1985-08-02 | 1987-05-26 | Hoover Dennis J | Oxa- and azahomocyclostatine polypeptides |
US4599198A (en) * | 1985-08-02 | 1986-07-08 | Pfizer Inc. | Intermediates in polypeptide synthesis |
CA1282549C (fr) * | 1985-11-12 | 1991-04-02 | Eric M. Gordon | Inhibiteurs de l'aminocarbonyl resine |
CA1297631C (fr) * | 1985-12-23 | 1992-03-17 | Sesha I. Natarajan | Inhibiteurs de la renine a groupement ureido |
US4757050A (en) * | 1985-12-23 | 1988-07-12 | E. R. Squibb Sons, Inc. | Ureido renin inhibitors |
US4880938A (en) * | 1986-06-16 | 1989-11-14 | Merck & Co., Inc. | Amino acid analogs |
DE3635907A1 (de) * | 1986-10-22 | 1988-04-28 | Merck Patent Gmbh | Hydroxy-aminosaeurederivate |
NL8800100A (nl) * | 1987-01-21 | 1988-08-16 | Sandoz Ag | Nieuwe peptidederivaten en werkwijzen voor het bereiden en toepassen van deze derivaten. |
USH725H (en) * | 1987-02-26 | 1990-01-02 | E. R. Squibb & Sons, Inc. | Ureido amino and imino acids, compositions and methods for use |
GB8707412D0 (en) * | 1987-03-27 | 1987-04-29 | Fujisawa Pharmaceutical Co | Peptide compounds |
DE3830825A1 (de) * | 1987-09-15 | 1989-03-23 | Sandoz Ag | Hydrophile reninhemmer, ihre herstellung und verwendung |
IL89900A0 (en) * | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
US4977277A (en) * | 1988-05-09 | 1990-12-11 | Abbott Laboratories | Functionalized peptidyl aminodiols and -triols 4-amino-5-cyclohexyl-3-hydroxy-1,2-oxopentane and derivatives thereof |
IL90218A0 (en) * | 1988-05-13 | 1989-12-15 | Abbott Lab | Retroviral protease inhibitors |
CA1340588C (fr) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Derive d'aminoacides |
IL91307A0 (en) * | 1988-08-24 | 1990-03-19 | Merck & Co Inc | Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them |
CA2012306A1 (fr) * | 1989-03-28 | 1990-09-28 | Werner Neidhart | Derives d'acides amines |
JP2701932B2 (ja) * | 1989-04-10 | 1998-01-21 | サントリー株式会社 | タンパク質分解酵素阻害剤 |
DE3912829A1 (de) * | 1989-04-19 | 1990-10-25 | Bayer Ag | Verwendung von renininhibitorischen peptiden als mittel gegen retroviren |
TW225540B (fr) * | 1990-06-28 | 1994-06-21 | Shionogi & Co | |
US5289728A (en) * | 1990-11-08 | 1994-03-01 | Jr Johanson, Inc. | Flow-no-flow tester |
JPH06503092A (ja) * | 1990-11-19 | 1994-04-07 | モンサント カンパニー | レトロウイルスプロテアーゼ阻害剤 |
AU3278293A (en) * | 1991-12-20 | 1993-07-28 | Syntex (U.S.A.) Inc. | Cyclic amides of 3-amino-2-hydroxy-carboxylic acids as hiv-protease inhibitors |
DE122007000045I2 (de) * | 1992-08-25 | 2011-07-21 | Gd Searle Llc Gd Searle Llc | Darunavir oder pharmazeutisch vertragliche Salze, Hydroxyethylaminosulfonamide verwendbar als InhibiEster oder Prodrugs davon. toren retroviraler Proteasen. |
IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
ES2118364T3 (es) * | 1992-10-30 | 1998-09-16 | Searle & Co | Derivados de acido hidroxietilamino-sulfamico utiles como inhibidores de proteasas retroviricas. |
EP0705320A4 (fr) * | 1993-06-21 | 1996-06-12 | Exxon Research Engineering Co | Systeme de craquage catalytique |
DK0715618T3 (da) * | 1993-08-24 | 1999-08-23 | Searle & Co | Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser |
UA49803C2 (uk) * | 1994-06-03 | 2002-10-15 | Дж.Д. Сьорль Енд Ко | Спосіб лікування ретровірусних інфекцій |
US5756533A (en) * | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
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1995
- 1995-06-07 US US08/474,052 patent/US5756533A/en not_active Expired - Fee Related
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1996
- 1996-03-07 EE EE9700201A patent/EE04349B1/xx not_active IP Right Cessation
- 1996-03-07 CN CNB961936207A patent/CN1204144C/zh not_active Expired - Fee Related
- 1996-03-07 KR KR1019970706313A patent/KR100377855B1/ko not_active IP Right Cessation
- 1996-03-07 EA EA199700221A patent/EA000470B1/ru not_active IP Right Cessation
- 1996-03-07 US US08/894,900 patent/US5968970A/en not_active Expired - Fee Related
- 1996-03-07 AU AU50294/96A patent/AU705268B2/en not_active Ceased
- 1996-03-07 DK DK96907135T patent/DK0813542T3/da active
- 1996-03-07 EP EP96907135A patent/EP0813542B1/fr not_active Expired - Lifetime
- 1996-03-07 NZ NZ303861A patent/NZ303861A/xx unknown
- 1996-03-07 WO PCT/US1996/002684 patent/WO1996028463A1/fr active IP Right Grant
- 1996-03-07 SK SK1224-97A patent/SK285688B6/sk unknown
- 1996-03-07 JP JP52764896A patent/JP4091111B2/ja not_active Expired - Fee Related
- 1996-03-07 PT PT96907135T patent/PT813542E/pt unknown
- 1996-03-07 HU HU9801562A patent/HUP9801562A3/hu unknown
- 1996-03-07 DE DE69624346T patent/DE69624346T2/de not_active Expired - Fee Related
- 1996-03-07 CZ CZ0282497A patent/CZ297719B6/cs not_active IP Right Cessation
- 1996-03-07 ES ES96907135T patent/ES2187640T3/es not_active Expired - Lifetime
- 1996-03-07 AT AT96907135T patent/ATE226213T1/de not_active IP Right Cessation
- 1996-03-07 EP EP02011526A patent/EP1258491A1/fr not_active Withdrawn
- 1996-03-07 BR BR9607638A patent/BR9607638A/pt not_active Application Discontinuation
- 1996-03-07 CA CA002215061A patent/CA2215061A1/fr not_active Abandoned
- 1996-03-07 PL PL96322784A patent/PL184748B1/pl not_active IP Right Cessation
- 1996-07-03 UA UA97104995A patent/UA56130C2/uk unknown
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1997
- 1997-09-09 NO NO974148A patent/NO974148L/no unknown
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1998
- 1998-03-03 US US09/033,897 patent/US5965601A/en not_active Expired - Fee Related
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