EE03529B1 - Kamptotetsiinderivaadid, nende valmistamise meetod ja kasutamine kasvajavastaste ainetena - Google Patents

Kamptotetsiinderivaadid, nende valmistamise meetod ja kasutamine kasvajavastaste ainetena

Info

Publication number
EE03529B1
EE03529B1 EE9800259A EE9800259A EE03529B1 EE 03529 B1 EE03529 B1 EE 03529B1 EE 9800259 A EE9800259 A EE 9800259A EE 9800259 A EE9800259 A EE 9800259A EE 03529 B1 EE03529 B1 EE 03529B1
Authority
EE
Estonia
Prior art keywords
pct
camptothecin derivatives
preparation
antitumor agents
date aug
Prior art date
Application number
EE9800259A
Other languages
English (en)
Estonian (et)
Other versions
EE9800259A (et
Inventor
Merlini Lucio
Penco Sergio
Zunino Franco
Original Assignee
Istituto Nazionale Per Lo Studio E La Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11373368&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03529(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Istituto Nazionale Per Lo Studio E La Cura Dei Tumori filed Critical Istituto Nazionale Per Lo Studio E La Cura Dei Tumori
Publication of EE9800259A publication Critical patent/EE9800259A/xx
Publication of EE03529B1 publication Critical patent/EE03529B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EE9800259A 1996-02-23 1997-02-19 Kamptotetsiinderivaadid, nende valmistamise meetod ja kasutamine kasvajavastaste ainetena EE03529B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI000338A IT1282673B1 (it) 1996-02-23 1996-02-23 Derivati della camptotecina e loro uso come agenti antitumorali
PCT/EP1997/000786 WO1997031003A1 (en) 1996-02-23 1997-02-19 Camptothecin derivatives and the use thereof as antitumor agents

Publications (2)

Publication Number Publication Date
EE9800259A EE9800259A (et) 1999-02-15
EE03529B1 true EE03529B1 (et) 2001-10-15

Family

ID=11373368

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800259A EE03529B1 (et) 1996-02-23 1997-02-19 Kamptotetsiinderivaadid, nende valmistamise meetod ja kasutamine kasvajavastaste ainetena

Country Status (22)

Country Link
US (2) US6130227A (ko)
EP (1) EP0885230B1 (ko)
JP (1) JP4171527B2 (ko)
KR (1) KR100497906B1 (ko)
CN (1) CN1107677C (ko)
AT (1) ATE221071T1 (ko)
AU (1) AU718361B2 (ko)
BR (1) BR9707622B1 (ko)
CZ (1) CZ289268B6 (ko)
DE (1) DE69714220T2 (ko)
DK (1) DK0885230T3 (ko)
EE (1) EE03529B1 (ko)
ES (1) ES2180932T3 (ko)
HU (1) HUP9900987A3 (ko)
IL (1) IL125856A (ko)
IT (1) IT1282673B1 (ko)
NZ (1) NZ331126A (ko)
PT (1) PT885230E (ko)
RU (1) RU2165935C2 (ko)
SK (1) SK283217B6 (ko)
UA (1) UA49005C2 (ko)
WO (1) WO1997031003A1 (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE211931T1 (de) * 1998-06-26 2002-02-15 Quanam Medical Corp Topoisomerase inhibitoren zur restenose- prevention
ES2175919T3 (es) * 1999-03-09 2002-11-16 Sigma Tau Ind Farmaceuti Derivados del camptothecin con actividad antitumoral.
US7105492B2 (en) 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
AR025587A1 (es) 1999-09-13 2002-12-04 Hoffmann La Roche Formulaciones en dispersion que contienen inhibidores de lipasa
WO2002083938A2 (en) * 2001-04-11 2002-10-24 Emerald Biostructures, Inc. Screening methods for identifying ligands
US7067666B2 (en) * 2003-06-27 2006-06-27 Research Triangle Institute 7-substituted camptothecin and camptothecin analogs and methods for producing the same
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
EA016487B1 (ru) 2005-12-21 2012-05-30 Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. Лечение резистентных к лекарственным препаратам опухолей
WO2007095389A2 (en) * 2006-02-17 2007-08-23 Novacea, Inc. Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs
CN101033230B (zh) 2006-03-10 2010-12-08 中国科学院上海药物研究所 一类喜树碱衍生物及其应用
ITMI20061474A1 (it) * 2006-07-26 2008-01-27 Indena Spa Derivati della camptotecina ad attivita antitumorale
CN102731516B (zh) * 2011-04-07 2014-07-02 宁波天衡药业股份有限公司 一类具有抗肿瘤活性的喜树碱衍生物
CN104774209B (zh) * 2014-01-15 2018-06-19 上海海和药物研究开发有限公司 一种9-烯丙基喜树碱衍生物的合成方法
CN117940432A (zh) * 2021-09-01 2024-04-26 上海弼领生物技术有限公司 一种喜树碱类化合物、其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
JPS58154582A (ja) * 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
AU718799C (en) * 1996-08-19 2004-02-12 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives

Also Published As

Publication number Publication date
PT885230E (pt) 2002-12-31
NZ331126A (en) 2000-02-28
IT1282673B1 (it) 1998-03-31
ATE221071T1 (de) 2002-08-15
EE9800259A (et) 1999-02-15
EP0885230A1 (en) 1998-12-23
JP4171527B2 (ja) 2008-10-22
ITMI960338A0 (ko) 1996-02-23
UA49005C2 (uk) 2002-09-16
IL125856A (en) 2001-08-26
CN1107677C (zh) 2003-05-07
CZ265298A3 (cs) 1999-01-13
US6130227A (en) 2000-10-10
BR9707622A (pt) 1999-07-27
AU1875397A (en) 1997-09-10
WO1997031003A1 (en) 1997-08-28
EP0885230B1 (en) 2002-07-24
BR9707622B1 (pt) 2010-08-10
HUP9900987A2 (hu) 1999-08-30
SK112798A3 (en) 1999-01-11
AU718361B2 (en) 2000-04-13
CN1211987A (zh) 1999-03-24
US6306868B1 (en) 2001-10-23
DE69714220T2 (de) 2002-11-14
SK283217B6 (sk) 2003-03-04
ES2180932T3 (es) 2003-02-16
DK0885230T3 (da) 2002-11-18
KR19990087110A (ko) 1999-12-15
CZ289268B6 (cs) 2001-12-12
JP2000505448A (ja) 2000-05-09
ITMI960338A1 (it) 1997-08-23
HUP9900987A3 (en) 2000-01-28
IL125856A0 (en) 1999-04-11
KR100497906B1 (ko) 2006-03-09
DE69714220D1 (de) 2002-08-29
RU2165935C2 (ru) 2001-04-27

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Legal Events

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KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

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KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20091231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20110219