EE03529B1 - Kamptotetsiinderivaadid, nende valmistamise meetod ja kasutamine kasvajavastaste ainetena - Google Patents
Kamptotetsiinderivaadid, nende valmistamise meetod ja kasutamine kasvajavastaste ainetenaInfo
- Publication number
- EE03529B1 EE03529B1 EE9800259A EE9800259A EE03529B1 EE 03529 B1 EE03529 B1 EE 03529B1 EE 9800259 A EE9800259 A EE 9800259A EE 9800259 A EE9800259 A EE 9800259A EE 03529 B1 EE03529 B1 EE 03529B1
- Authority
- EE
- Estonia
- Prior art keywords
- pct
- camptothecin derivatives
- preparation
- antitumor agents
- date aug
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI000338A IT1282673B1 (it) | 1996-02-23 | 1996-02-23 | Derivati della camptotecina e loro uso come agenti antitumorali |
PCT/EP1997/000786 WO1997031003A1 (en) | 1996-02-23 | 1997-02-19 | Camptothecin derivatives and the use thereof as antitumor agents |
Publications (2)
Publication Number | Publication Date |
---|---|
EE9800259A EE9800259A (et) | 1999-02-15 |
EE03529B1 true EE03529B1 (et) | 2001-10-15 |
Family
ID=11373368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EE9800259A EE03529B1 (et) | 1996-02-23 | 1997-02-19 | Kamptotetsiinderivaadid, nende valmistamise meetod ja kasutamine kasvajavastaste ainetena |
Country Status (22)
Country | Link |
---|---|
US (2) | US6130227A (en:Method) |
EP (1) | EP0885230B1 (en:Method) |
JP (1) | JP4171527B2 (en:Method) |
KR (1) | KR100497906B1 (en:Method) |
CN (1) | CN1107677C (en:Method) |
AT (1) | ATE221071T1 (en:Method) |
AU (1) | AU718361B2 (en:Method) |
BR (1) | BR9707622B1 (en:Method) |
CZ (1) | CZ289268B6 (en:Method) |
DE (1) | DE69714220T2 (en:Method) |
DK (1) | DK0885230T3 (en:Method) |
EE (1) | EE03529B1 (en:Method) |
ES (1) | ES2180932T3 (en:Method) |
HU (1) | HUP9900987A3 (en:Method) |
IL (1) | IL125856A (en:Method) |
IT (1) | IT1282673B1 (en:Method) |
NZ (1) | NZ331126A (en:Method) |
PT (1) | PT885230E (en:Method) |
RU (1) | RU2165935C2 (en:Method) |
SK (1) | SK283217B6 (en:Method) |
UA (1) | UA49005C2 (en:Method) |
WO (1) | WO1997031003A1 (en:Method) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE211931T1 (de) * | 1998-06-26 | 2002-02-15 | Quanam Medical Corp | Topoisomerase inhibitoren zur restenose- prevention |
US7105492B2 (en) * | 1999-03-09 | 2006-09-12 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
ES2175919T3 (es) * | 1999-03-09 | 2002-11-16 | Sigma Tau Ind Farmaceuti | Derivados del camptothecin con actividad antitumoral. |
AR025587A1 (es) | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones en dispersion que contienen inhibidores de lipasa |
AU2002258787A1 (en) * | 2001-04-11 | 2002-10-28 | Emerald Biostructures, Inc. | Screening methods for identifying ligands |
RU2319482C2 (ru) * | 2001-11-23 | 2008-03-20 | Чугаи Сейяку Кабусики Кайся | Способ идентификации противоопухолевых целевых ферментов |
JP2005525367A (ja) * | 2002-03-01 | 2005-08-25 | フアルマシア・イタリア・エツセ・ピー・アー | 塩酸イリノテカンの結晶多形 |
TW200306314A (en) * | 2002-04-16 | 2003-11-16 | Tanabe Seiyaku Co | Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation |
US7067666B2 (en) * | 2003-06-27 | 2006-06-27 | Research Triangle Institute | 7-substituted camptothecin and camptothecin analogs and methods for producing the same |
ITRM20030344A1 (it) * | 2003-07-14 | 2005-01-15 | Ist Naz Stud Cura Dei Tumori | 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi. |
TWI333492B (en) * | 2003-11-12 | 2010-11-21 | Smithkline Beecham Cork Ltd | Crystalline topotecan hydrochloride product and preparation thereof |
ATE548038T1 (de) * | 2005-12-21 | 2012-03-15 | Sigma Tau Ind Farmaceuti | Behandlung von arzneiresistenten tumoren |
WO2007095389A2 (en) * | 2006-02-17 | 2007-08-23 | Novacea, Inc. | Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs |
CN101033230B (zh) | 2006-03-10 | 2010-12-08 | 中国科学院上海药物研究所 | 一类喜树碱衍生物及其应用 |
ITMI20061474A1 (it) * | 2006-07-26 | 2008-01-27 | Indena Spa | Derivati della camptotecina ad attivita antitumorale |
CN102731516B (zh) * | 2011-04-07 | 2014-07-02 | 宁波天衡药业股份有限公司 | 一类具有抗肿瘤活性的喜树碱衍生物 |
CN104774209B (zh) * | 2014-01-15 | 2018-06-19 | 上海海和药物研究开发有限公司 | 一种9-烯丙基喜树碱衍生物的合成方法 |
CN117940432A (zh) * | 2021-09-01 | 2024-04-26 | 上海弼领生物技术有限公司 | 一种喜树碱类化合物、其制备方法和用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
JPS58154582A (ja) * | 1982-03-10 | 1983-09-14 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体およびその製造法 |
US5459269A (en) * | 1992-06-18 | 1995-10-17 | North Carolina State University | 14-halo-camptothecins |
US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
IL127800A (en) * | 1996-08-19 | 2005-11-20 | Bionumerik Pharmaceuticals Inc | Highly lipophilic 7-substituted camptothecin derivatives and pharmaceutical compositions containing them |
-
1996
- 1996-02-23 IT IT96MI000338A patent/IT1282673B1/it active IP Right Grant
-
1997
- 1997-02-19 IL IL12585697A patent/IL125856A/xx not_active IP Right Cessation
- 1997-02-19 US US09/125,512 patent/US6130227A/en not_active Expired - Fee Related
- 1997-02-19 WO PCT/EP1997/000786 patent/WO1997031003A1/en not_active Application Discontinuation
- 1997-02-19 EE EE9800259A patent/EE03529B1/xx not_active IP Right Cessation
- 1997-02-19 CN CN97192493A patent/CN1107677C/zh not_active Expired - Fee Related
- 1997-02-19 RU RU98117449/04A patent/RU2165935C2/ru not_active IP Right Cessation
- 1997-02-19 CZ CZ19982652A patent/CZ289268B6/cs not_active IP Right Cessation
- 1997-02-19 ES ES97905057T patent/ES2180932T3/es not_active Expired - Lifetime
- 1997-02-19 PT PT97905057T patent/PT885230E/pt unknown
- 1997-02-19 KR KR1019980706498A patent/KR100497906B1/ko not_active Expired - Fee Related
- 1997-02-19 AT AT97905057T patent/ATE221071T1/de not_active IP Right Cessation
- 1997-02-19 NZ NZ331126A patent/NZ331126A/en not_active IP Right Cessation
- 1997-02-19 JP JP52979197A patent/JP4171527B2/ja not_active Expired - Fee Related
- 1997-02-19 AU AU18753/97A patent/AU718361B2/en not_active Ceased
- 1997-02-19 SK SK1127-98A patent/SK283217B6/sk not_active IP Right Cessation
- 1997-02-19 DK DK97905057T patent/DK0885230T3/da active
- 1997-02-19 BR BRPI9707622-8A patent/BR9707622B1/pt not_active IP Right Cessation
- 1997-02-19 EP EP97905057A patent/EP0885230B1/en not_active Expired - Lifetime
- 1997-02-19 UA UA98084449A patent/UA49005C2/uk unknown
- 1997-02-19 HU HU9900987A patent/HUP9900987A3/hu unknown
- 1997-02-19 DE DE69714220T patent/DE69714220T2/de not_active Expired - Lifetime
-
2000
- 2000-08-22 US US09/643,256 patent/US6306868B1/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
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KB4A | Valid patent at the end of a year |
Effective date: 20021231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20031231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20051231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20091231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20101231 |
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MM4A | Lapsed by not paying the annual fees |
Effective date: 20110219 |