EE03394B1 - Ropivakaiinvesinikkloriidmonohüdraadi saamise protsess - Google Patents
Ropivakaiinvesinikkloriidmonohüdraadi saamise protsessInfo
- Publication number
- EE03394B1 EE03394B1 EE9700301A EE9700301A EE03394B1 EE 03394 B1 EE03394 B1 EE 03394B1 EE 9700301 A EE9700301 A EE 9700301A EE 9700301 A EE9700301 A EE 9700301A EE 03394 B1 EE03394 B1 EE 03394B1
- Authority
- EE
- Estonia
- Prior art keywords
- preparation
- hydrochloride monohydrate
- ropivacaine hydrochloride
- ropivacaine
- monohydrate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9501808A SE9501808D0 (sv) | 1995-05-16 | 1995-05-16 | New process |
| PCT/SE1996/000563 WO1996036606A1 (en) | 1995-05-16 | 1996-04-30 | New process for the preparation of ropivacaine hydrochloride monohydrate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE9700301A EE9700301A (et) | 1998-06-15 |
| EE03394B1 true EE03394B1 (et) | 2001-04-16 |
Family
ID=20398325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9700301A EE03394B1 (et) | 1995-05-16 | 1996-04-30 | Ropivakaiinvesinikkloriidmonohüdraadi saamise protsess |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US5959112A (cs) |
| EP (1) | EP0828711B1 (cs) |
| JP (1) | JP3079112B2 (cs) |
| KR (1) | KR100425232B1 (cs) |
| CN (1) | CN1121388C (cs) |
| AR (1) | AR002737A1 (cs) |
| AT (1) | ATE207900T1 (cs) |
| AU (1) | AU696875B2 (cs) |
| BR (1) | BR9608820A (cs) |
| CA (1) | CA2219308C (cs) |
| CZ (1) | CZ290576B6 (cs) |
| DE (1) | DE69616543T2 (cs) |
| DK (1) | DK0828711T3 (cs) |
| EE (1) | EE03394B1 (cs) |
| ES (1) | ES2166888T3 (cs) |
| HK (1) | HK1009805A1 (cs) |
| HU (1) | HU221793B1 (cs) |
| IL (1) | IL118178A (cs) |
| IN (1) | IN185146B (cs) |
| IS (1) | IS1832B (cs) |
| MY (1) | MY115018A (cs) |
| NO (1) | NO309035B1 (cs) |
| NZ (1) | NZ308249A (cs) |
| PL (1) | PL184767B1 (cs) |
| PT (1) | PT828711E (cs) |
| RU (1) | RU2167153C2 (cs) |
| SA (1) | SA96160764B1 (cs) |
| SE (1) | SE9501808D0 (cs) |
| SK (1) | SK281812B6 (cs) |
| TR (1) | TR199701362T1 (cs) |
| TW (1) | TW340841B (cs) |
| UA (1) | UA46770C2 (cs) |
| WO (1) | WO1996036606A1 (cs) |
| ZA (1) | ZA963545B (cs) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69824632T2 (de) | 1997-11-12 | 2005-06-09 | Mitsubishi Chemical Corp. | Purinderivate und medikamente, welche dieselben als aktiven bestandteil enthalten |
| WO2000068231A1 (fr) | 1999-05-11 | 2000-11-16 | Mitsubishi Chemical Corporation | Dihydrate derive de purine, medicaments le contenant comme principe actif et intermediaire utilise dans sa preparation |
| WO2001029002A1 (en) * | 1999-10-20 | 2001-04-26 | Smithkline Beecham Plc | Process for the preparation of 4-(fluorophenyl)piperidine esters |
| BRPI0104491B8 (pt) * | 2001-10-10 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica. |
| US20060270708A1 (en) * | 2005-05-25 | 2006-11-30 | Navinta Llc | Novel process for preparation of isotonic aqueous injection of ropivacaine |
| WO2009044404A1 (en) * | 2007-10-01 | 2009-04-09 | Ramniwas Goel | Process for the preparation of (s)-ropivacaine hydrochloride monohydrate |
| CN102093284B (zh) * | 2010-12-29 | 2013-05-08 | 宜昌人福药业有限责任公司 | 富集哌啶-2-甲酰苯胺类旋光化合物的方法 |
| WO2014009964A1 (en) * | 2012-07-11 | 2014-01-16 | Neon Laboratories Limited | Process for enantiomeric enrichment of 2 ', 6 ' - pipecoloxylidide |
| CN103086954A (zh) * | 2013-02-04 | 2013-05-08 | 山东省医药工业研究所 | 一种制备罗哌卡因的方法 |
| CN104003930B (zh) * | 2014-06-13 | 2016-06-08 | 山东金诃药物研究开发有限公司 | 一种盐酸罗哌卡因的制备方法 |
| CN113105386B (zh) * | 2021-04-10 | 2022-11-25 | 河北一品制药股份有限公司 | 一种盐酸罗哌卡因一水合物工业化的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE341404B (cs) * | 1967-05-18 | 1971-12-27 | Sterling Drug Inc | |
| DE3379266D1 (en) * | 1983-08-01 | 1989-04-06 | Astra Laekemedel Ab | L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same |
| SE451840B (sv) * | 1986-01-03 | 1987-11-02 | Astra Laekemedel Ab | Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning |
-
1995
- 1995-05-16 SE SE9501808A patent/SE9501808D0/xx unknown
-
1996
- 1996-04-19 IN IN837DE1996 patent/IN185146B/en unknown
- 1996-04-30 AT AT96914488T patent/ATE207900T1/de active
- 1996-04-30 ES ES96914488T patent/ES2166888T3/es not_active Expired - Lifetime
- 1996-04-30 DE DE69616543T patent/DE69616543T2/de not_active Expired - Lifetime
- 1996-04-30 PL PL96323461A patent/PL184767B1/pl unknown
- 1996-04-30 RU RU97120751/04A patent/RU2167153C2/ru active
- 1996-04-30 EP EP96914488A patent/EP0828711B1/en not_active Expired - Lifetime
- 1996-04-30 TR TR97/01362T patent/TR199701362T1/xx unknown
- 1996-04-30 AU AU57832/96A patent/AU696875B2/en not_active Expired
- 1996-04-30 NZ NZ308249A patent/NZ308249A/en not_active IP Right Cessation
- 1996-04-30 CZ CZ19973452A patent/CZ290576B6/cs not_active IP Right Cessation
- 1996-04-30 EE EE9700301A patent/EE03394B1/xx unknown
- 1996-04-30 KR KR1019970708171A patent/KR100425232B1/ko active IP Right Grant
- 1996-04-30 HU HU9900327A patent/HU221793B1/hu active IP Right Grant
- 1996-04-30 CN CN96195279A patent/CN1121388C/zh not_active Expired - Lifetime
- 1996-04-30 WO PCT/SE1996/000563 patent/WO1996036606A1/en active IP Right Grant
- 1996-04-30 US US08/647,994 patent/US5959112A/en not_active Expired - Lifetime
- 1996-04-30 SK SK1512-97A patent/SK281812B6/sk not_active IP Right Cessation
- 1996-04-30 CA CA002219308A patent/CA2219308C/en not_active Expired - Fee Related
- 1996-04-30 JP JP08534738A patent/JP3079112B2/ja not_active Expired - Lifetime
- 1996-04-30 DK DK96914488T patent/DK0828711T3/da active
- 1996-04-30 BR BR9608820A patent/BR9608820A/pt not_active Application Discontinuation
- 1996-04-30 PT PT96914488T patent/PT828711E/pt unknown
- 1996-04-30 UA UA97126021A patent/UA46770C2/uk unknown
- 1996-05-03 ZA ZA963545A patent/ZA963545B/xx unknown
- 1996-05-05 SA SA96160764A patent/SA96160764B1/ar unknown
- 1996-05-06 TW TW085105371A patent/TW340841B/zh not_active IP Right Cessation
- 1996-05-07 IL IL11817896A patent/IL118178A/xx not_active IP Right Cessation
- 1996-05-07 AR ARP960102486A patent/AR002737A1/es unknown
- 1996-05-16 MY MYPI96001857A patent/MY115018A/en unknown
-
1997
- 1997-11-04 IS IS4607A patent/IS1832B/is unknown
- 1997-11-13 NO NO975220A patent/NO309035B1/no not_active IP Right Cessation
-
1998
- 1998-09-17 HK HK98110674A patent/HK1009805A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB4A | Valid patent at the end of a year |
Effective date: 20021231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20031231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20051231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
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| HC1A | Change of owner name | ||
| KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20091231 |
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| KB4A | Valid patent at the end of a year |
Effective date: 20101231 |