EE03118B1 - Proteiinravim ja selle valmistamismeetod - Google Patents

Proteiinravim ja selle valmistamismeetod

Info

Publication number
EE03118B1
EE03118B1 EE9400380A EE9400380A EE03118B1 EE 03118 B1 EE03118 B1 EE 03118B1 EE 9400380 A EE9400380 A EE 9400380A EE 9400380 A EE9400380 A EE 9400380A EE 03118 B1 EE03118 B1 EE 03118B1
Authority
EE
Estonia
Prior art keywords
factor viii
pct
aqueous solution
present
activity
Prior art date
Application number
EE9400380A
Other languages
English (en)
Estonian (et)
Inventor
�sterberg Thomas
Fatouros Angelica
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Publication of EE03118B1 publication Critical patent/EE03118B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
EE9400380A 1993-05-07 1994-11-17 Proteiinravim ja selle valmistamismeetod EE03118B1 (et)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE19939301581A SE9301581D0 (sv) 1993-05-07 1993-05-07 Protein formulation

Publications (1)

Publication Number Publication Date
EE03118B1 true EE03118B1 (et) 1998-10-15

Family

ID=20389868

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9400380A EE03118B1 (et) 1993-05-07 1994-11-17 Proteiinravim ja selle valmistamismeetod

Country Status (24)

Country Link
US (1) US5962650A (sv)
EP (1) EP0700299B1 (sv)
JP (1) JP3751633B2 (sv)
KR (1) KR100304143B1 (sv)
CN (1) CN1113655C (sv)
AT (1) ATE218354T1 (sv)
AU (1) AU681883B2 (sv)
CA (1) CA2161350C (sv)
CZ (1) CZ293527B6 (sv)
DE (1) DE69430745T2 (sv)
DK (1) DK0700299T3 (sv)
EE (1) EE03118B1 (sv)
ES (1) ES2177579T3 (sv)
FI (1) FI111910B (sv)
HU (1) HU215263B (sv)
NO (1) NO321769B1 (sv)
NZ (1) NZ266031A (sv)
PL (1) PL174866B1 (sv)
PT (1) PT700299E (sv)
RU (1) RU2142290C1 (sv)
SE (1) SE9301581D0 (sv)
SK (1) SK283002B6 (sv)
WO (1) WO1994026286A1 (sv)
ZA (1) ZA942251B (sv)

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IL113010A (en) * 1994-03-31 1999-10-28 Pharmacia & Upjohn Ab Pharmaceutical formulation comprising factor viii with an activity of at least 500iu/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration
SE9403915D0 (sv) * 1994-11-14 1994-11-14 Annelie Almstedt Process A
SE9501189D0 (sv) * 1995-03-31 1995-03-31 Pharmacia Ab Protein formulation
US5929031A (en) * 1995-05-02 1999-07-27 Baxter Biotech Technology Sarl Storage stable hemoglobin solutions
US5925738A (en) * 1995-12-01 1999-07-20 The American National Red Cross Methods of production and use of liquid formulations of plasma proteins
US7560107B2 (en) 1996-06-26 2009-07-14 Emory University Modified factor VIII
US5763401A (en) * 1996-07-12 1998-06-09 Bayer Corporation Stabilized albumin-free recombinant factor VIII preparation having a low sugar content
CA2634663C (en) * 1999-02-22 2009-08-25 University Of Connecticut Novel albumin-free factor viii formulations
EP1194161B1 (en) * 1999-07-13 2005-11-23 Biovitrum Ab Stable factor viii compositions
JP3466516B2 (ja) 1999-09-07 2003-11-10 科学技術振興事業団 安定保存可能な酸素輸液剤
AU2002351756A1 (en) 2001-12-21 2003-07-15 Novo Nordisk Health Care Ag Liquid composition of factor vii polypeptides
IL162618A0 (en) * 2001-12-21 2005-11-20 Novo Nordisk As Liquid composition of modified factor vii polypeptides
GB0207092D0 (en) 2002-03-26 2002-05-08 Sod Conseils Rech Applic Stable pharmaceutical composition containing factor VIII
US20040009918A1 (en) * 2002-05-03 2004-01-15 Hanne Nedergaard Stabilised solid compositions of modified factor VII
AU2003240438A1 (en) * 2002-06-21 2004-01-06 Novo Nordisk A/S Stabilised solid compositions of factor vii polypeptides
US7897734B2 (en) 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
AU2004241698A1 (en) * 2003-05-23 2004-12-02 Novo Nordisk Health Care Ag Protein stabilization in solution
ES2382157T3 (es) * 2003-06-25 2012-06-05 Novo Nordisk Health Care Ag Composición líquida de polipépttidos del factor VII
JP5306597B2 (ja) * 2003-07-01 2013-10-02 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第ｖｉｉ因子ポリペプチドの液体水性薬学的組成物
ES2574581T3 (es) 2003-08-14 2016-06-20 Novo Nordisk Health Care Ag Composición farmacéutica líquida acuosa de polipéptidos de tipo Factor VII
TR201809670T4 (tr) 2003-12-19 2018-07-23 Novo Nordisk Healthcare Ag Faktör VII polipeptitlerinin stabilize edilmiş kompozisyonları.
WO2005107776A1 (en) * 2004-05-03 2005-11-17 Emory University METHOD OF ADMINISTERING PORCINE B-DOMAINLESS fVIII
US7494974B2 (en) 2006-10-24 2009-02-24 Ikor, Inc. Carboxymethylated cross-linked tetrameric hemoglobin
US7504377B2 (en) 2006-10-23 2009-03-17 Ikor, Inc. Nitric oxide-blocked cross-linked tetrameric hemoglobin
PT1982731E (pt) * 2007-04-17 2010-07-06 Schwabe Willmar Gmbh & Co PROCESSO PARA PRODUÆO DE SOLUÎES DE EXTRACTOS DE PELARGËNIO ESTáVEIS EM ARMAZENAMENTO
ATE503763T1 (de) * 2007-07-11 2011-04-15 Novo Nordisk As Aufreinigung von faktor viii unter verwendung eines mixed-mode oder multimodalen harzes
EP2113564A1 (en) 2008-05-01 2009-11-04 Arecor Limited Protein formulation
JP2012500250A (ja) 2008-08-21 2012-01-05 オクタファルマ アクチェン ゲゼルシャフト 組換えにより産生したヒト第ｖｉｉｉ及び第ｉｘ因子
KR101691443B1 (ko) * 2008-09-03 2016-12-30 옥타파마 아게 재조합에 의해 제조된 인자 ⅷ을 위한 신규한 보호 조성물
JP5779780B2 (ja) 2008-11-07 2015-09-16 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 第ｖｉｉｉ因子製剤
US10172949B2 (en) 2009-06-09 2019-01-08 Prolong Pharmaceuticals, LLC Hemoglobin compositions
US10172950B2 (en) 2009-06-09 2019-01-08 Prolong Pharmaceuticals, LLC Hemoglobin compositions
LT2440239T (lt) 2009-06-09 2017-12-11 Prolong Pharmaceuticals, LLC Hemoglobino kompozicijos
GB0915480D0 (en) * 2009-09-04 2009-10-07 Arecor Ltd Stable formulation of factor viii
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
PT2608816T (pt) 2010-08-25 2023-10-12 Dartmouth College Método para melhorar a qualidade e a sobrevivência dos glóbulos vermelhos durante o armazenamento
BR112013011041B1 (pt) 2010-11-05 2021-05-25 Baxalta GmbH variante de fator viii, método para produzir uma variante de fviii, uso da variante de fator viii, e, composição farmacêutica
ES2957338T3 (es) 2010-11-05 2024-01-17 Hemanext Inc Irradiación de glóbulos rojos y almacenamiento anaeróbico
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
EP3533507B1 (en) 2011-08-10 2022-03-30 Hemanext Inc. Integrated leukocyte, oxygen and/or co2 depletion, and plasma separation filter device
US9877476B2 (en) 2013-02-28 2018-01-30 New Health Sciences, Inc. Gas depletion and gas addition devices for blood treatment
ES2524516B1 (es) * 2014-05-29 2015-03-31 Grifols Worldwide Operations Limited Procedimiento de preparación de albúmina humana con nivel de oxígeno disuelto reducido
KR20180012242A (ko) 2015-03-10 2018-02-05 뉴 헬스 사이언시즈 인코포레이티드 산소 감소 1회용 키트, 장치 및 이의 사용 방법
IL285359B2 (en) 2015-04-23 2024-01-01 Hemanext Inc Anaerobic blood storage containers
US11013771B2 (en) 2015-05-18 2021-05-25 Hemanext Inc. Methods for the storage of whole blood, and compositions thereof
IL282627B2 (en) 2016-05-27 2023-10-01 Hemanext Inc Anaerobic blood storage and pathogen inactivation method
BR112021000965A2 (pt) 2018-08-07 2021-04-27 Glaxosmithkline Biologicals S.A. processos e vacinas

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US2896381A (en) * 1954-05-27 1959-07-28 Hodes Lange Corp Method and apparatus for treating and filling ampoules
US3143471A (en) * 1962-01-18 1964-08-04 Merck & Co Inc Argon method of drying and preserving lyophilized therapeutic products
US4165370A (en) * 1976-05-21 1979-08-21 Coval M L Injectable gamma globulin
US4783441A (en) * 1979-04-30 1988-11-08 Hoechst Aktiengesellschaft Aqueous protein solutions stable to denaturation
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4481189A (en) * 1982-04-14 1984-11-06 New York Blood Center Inc. Process for preparing sterilized plasma and plasma derivatives
US4727027A (en) * 1983-05-02 1988-02-23 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
US4597966A (en) * 1985-01-09 1986-07-01 Ortho Diagnostic Systems, Inc. Histidine stabilized immunoglobulin and method of preparation
DE3577801D1 (de) * 1985-08-05 1990-06-28 Immuno Ag Verfahren zur herstellung von praeparationen auf basis von blutgerinnungsfaktoren.
US4709819A (en) * 1986-07-23 1987-12-01 Environmental Diagnostics, Inc. Method for preserving plated media and product
CA1292686C (en) * 1986-10-27 1991-12-03 Ze'ev Shaked Pharmaceutical compositions of recombinant interleukin-2 and formulation process
CA1329760C (en) * 1987-10-29 1994-05-24 Ted C. K. Lee Plasma and recombinant protein formulations in high ionic strength media
US4877608A (en) * 1987-11-09 1989-10-31 Rorer Pharmaceutical Corporation Pharmaceutical plasma protein formulations in low ionic strength media
FR2630115B1 (fr) * 1988-04-14 1994-10-28 Merieux Inst Procede de stabilisation des solutions d'albumine humaine et solution obtenue
GB8808810D0 (en) * 1988-04-14 1988-05-18 Biopharm Clinical Research Ltd Heparin-containing formulations
US5096885A (en) * 1988-04-15 1992-03-17 Genentech, Inc. Human growth hormone formulation
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
DE4001451A1 (de) * 1990-01-19 1991-08-01 Octapharma Ag Stabile injizierbare loesungen von faktor viii und faktor ix
DE4111393A1 (de) * 1991-04-09 1992-10-15 Behringwerke Ag Stabilisierte faktor viii-praeparationen
EP0789612B1 (en) * 1994-10-31 2002-09-04 Kimberly-Clark Worldwide, Inc. High density nonwoven filter media

Also Published As

Publication number Publication date
RU2142290C1 (ru) 1999-12-10
HUT73693A (en) 1996-09-30
JPH08509745A (ja) 1996-10-15
DE69430745T2 (de) 2002-10-17
HU9503171D0 (en) 1996-01-29
FI111910B (sv) 2003-10-15
FI955305A0 (sv) 1995-11-06
DE69430745D1 (de) 2002-07-11
FI955305A (sv) 1995-11-06
WO1994026286A1 (en) 1994-11-24
SE9301581D0 (sv) 1993-05-07
SK283002B6 (sk) 2003-01-09
CZ286995A3 (en) 1996-05-15
US5962650A (en) 1999-10-05
KR100304143B1 (ko) 2001-11-22
EP0700299A1 (en) 1996-03-13
CA2161350A1 (en) 1994-11-24
EP0700299B1 (en) 2002-06-05
JP3751633B2 (ja) 2006-03-01
AU681883B2 (en) 1997-09-11
CN1122573A (zh) 1996-05-15
ZA942251B (en) 1994-11-01
ATE218354T1 (de) 2002-06-15
NO954457D0 (no) 1995-11-07
PL311567A1 (en) 1996-02-19
NZ266031A (en) 1997-04-24
SK138395A3 (en) 1997-02-05
PL174866B1 (pl) 1998-09-30
CN1113655C (zh) 2003-07-09
NO954457L (no) 1995-11-07
NO321769B1 (no) 2006-07-03
DK0700299T3 (da) 2002-09-23
CZ293527B6 (cs) 2004-05-12
AU6659794A (en) 1994-12-12
KR960702317A (ko) 1996-04-27
HU215263B (hu) 1998-11-30
PT700299E (pt) 2002-11-29
ES2177579T3 (es) 2002-12-16
CA2161350C (en) 2007-10-30

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