ECSP11011307A - Comprimidos para terapia de combinacion - Google Patents

Comprimidos para terapia de combinacion

Info

Publication number
ECSP11011307A
ECSP11011307A EC2011011307A ECSP11011307A ECSP11011307A EC SP11011307 A ECSP11011307 A EC SP11011307A EC 2011011307 A EC2011011307 A EC 2011011307A EC SP11011307 A ECSP11011307 A EC SP11011307A EC SP11011307 A ECSP11011307 A EC SP11011307A
Authority
EC
Ecuador
Prior art keywords
tablets
combination therapy
formula
compound
salt
Prior art date
Application number
EC2011011307A
Other languages
English (en)
Inventor
Joanna M Koziara
Mark M Menning
Reza Oliyai
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41722740&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP11011307(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of ECSP11011307A publication Critical patent/ECSP11011307A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

La invención proporciona formas farmaceuticas sólidas (por ejemplo comprimidos) que comprende un compuesto de Formula I, un compuesto de Formula II, un compuesto de Formula III y una sal de Formula IV.
EC2011011307A 2009-02-06 2011-09-06 Comprimidos para terapia de combinacion ECSP11011307A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15065509P 2009-02-06 2009-02-06
US15065209P 2009-02-06 2009-02-06

Publications (1)

Publication Number Publication Date
ECSP11011307A true ECSP11011307A (es) 2011-10-31

Family

ID=41722740

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011011307A ECSP11011307A (es) 2009-02-06 2011-09-06 Comprimidos para terapia de combinacion

Country Status (31)

Country Link
US (2) US20100285122A1 (es)
EP (1) EP2393485B1 (es)
JP (2) JP5611242B2 (es)
KR (2) KR101738325B1 (es)
CN (1) CN102307573B (es)
AP (1) AP3250A (es)
AR (1) AR075369A1 (es)
AU (1) AU2010210598B2 (es)
BR (1) BRPI1008664A2 (es)
CA (1) CA2750521A1 (es)
CL (1) CL2011001885A1 (es)
CY (1) CY1116852T1 (es)
DK (1) DK2393485T3 (es)
EA (2) EA021313B1 (es)
EC (1) ECSP11011307A (es)
ES (1) ES2548886T3 (es)
HK (1) HK1164737A1 (es)
HR (1) HRP20151009T1 (es)
HU (1) HUE025822T2 (es)
IL (1) IL214227A (es)
MX (1) MX2011008289A (es)
NZ (1) NZ594214A (es)
PE (1) PE20110994A1 (es)
PL (1) PL2393485T3 (es)
PT (1) PT2393485E (es)
SG (3) SG10201706215UA (es)
SI (1) SI2393485T1 (es)
SM (1) SMT201500266B (es)
TW (1) TWI444367B (es)
UY (1) UY32424A (es)
WO (1) WO2010091197A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS54237B9 (sr) 2006-07-07 2019-07-31 Gilead Sciences Inc Modulatori farmakokinetičkih svojstava terapeutika
PL3150586T3 (pl) * 2007-02-23 2020-06-01 Gilead Sciences, Inc. Modulatory farmakokinetycznych właściwości środków terapeutycznych
EA201591353A1 (ru) * 2008-05-02 2016-01-29 Джилид Сайэнс, Инк. Применение частиц твердого носителя для улучшения технологических характеристик фармацевтического агента
EP2826466A1 (en) 2010-11-19 2015-01-21 Gilead Sciences, Inc. Therapeutic compositions comprising rilpivirin hcl and tenofovir disoproxil fumarate
PL2646005T3 (pl) * 2010-11-29 2019-12-31 Formac Pharmaceuticals N.V. Sprasowane formulacje uporządkowanych, mezoporowatych krzemionek
JP6122427B2 (ja) * 2011-07-07 2017-04-26 ヤンセン・サイエンシズ・アイルランド・ユーシー ダルナビル複合製剤
HRP20161696T4 (hr) 2011-08-16 2023-10-13 Gilead Sciences, Inc. Tenofovir alafenamid hemifumarat
AU2012327170A1 (en) * 2012-02-03 2013-08-22 Gilead Sciences, Inc. Therapeutic compounds
CA2863662A1 (en) * 2012-02-03 2013-08-08 Gilead Sciences, Inc. Combination therapy comprising tenofovir alafenamide hemifumarate and cobicistat for use in the treatment of viral infections
EP2819644A1 (en) * 2012-03-01 2015-01-07 Gilead Sciences, Inc. Spray dried formulations
CN103830192A (zh) * 2012-11-27 2014-06-04 安徽贝克生物制药有限公司 一种可粉末直接压片的富马酸替诺福韦二吡呋酯片剂及制备方法
SI3608325T1 (sl) 2012-12-21 2022-09-30 Gilead Sciences, Inc. Policiklične-karbamoilpiridonske spojine in njihova farmacevtska uporaba
JP6667556B2 (ja) 2015-06-30 2020-03-18 ギリアード サイエンシーズ， インコーポレイテッド テノホビルおよびエムトリシタビンを含む薬学的製剤
JP6621933B2 (ja) 2015-11-09 2019-12-18 ギリアード サイエンシス インコーポレーテッド ヒト免疫不全ウイルスを処置するための治療組成物
ES2806604T3 (es) 2016-02-02 2021-02-18 Sandoz Ag Formas cristalinas de monofumarato de tenofovir alafenamida

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA923641B (en) 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
US5922695A (en) 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
DE10153078A1 (de) * 2001-10-30 2003-05-22 Degussa Verwendung von Granulaten auf Basis von pyrogen hergestelltem Siliciumdioxid in pharmazeutischen Zusammensetzungen
PE20040840A1 (es) * 2002-11-20 2004-12-30 Japan Tobacco Inc Derivados de 4-oxoquinolina como inhibidores de la integrasa del vih
CN100375742C (zh) * 2002-11-20 2008-03-19 日本烟草产业株式会社 4-氧代喹啉化合物及其用途
JP3567162B1 (ja) * 2002-11-20 2004-09-22 日本たばこ産業株式会社 ４−オキソキノリン化合物及びそのｈｉｖインテグラーゼ阻害剤としての利用
CA2512319A1 (en) 2003-01-14 2004-08-05 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
MY134672A (en) 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) * 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
RU2008128424A (ru) * 2005-12-14 2010-01-20 Сипла Лимитед (In) Фармацевтическая комбинация, включающая нуклеотидный и нуклеозидный ингибиторы обратной транскриптазы (такие как тенофовир и ламивудин) в различных частях дозы
RS54237B9 (sr) * 2006-07-07 2019-07-31 Gilead Sciences Inc Modulatori farmakokinetičkih svojstava terapeutika
PL3150586T3 (pl) * 2007-02-23 2020-06-01 Gilead Sciences, Inc. Modulatory farmakokinetycznych właściwości środków terapeutycznych

Also Published As

Publication number Publication date
WO2010091197A3 (en) 2011-06-03
ES2548886T3 (es) 2015-10-21
CA2750521A1 (en) 2010-08-12
SG2014007744A (en) 2014-05-29
KR101738325B1 (ko) 2017-05-19
NZ594214A (en) 2013-05-31
IL214227A0 (en) 2011-09-27
JP2014221845A (ja) 2014-11-27
AP3250A (en) 2015-05-31
IL214227A (en) 2017-01-31
UY32424A (es) 2010-09-30
TW201040142A (en) 2010-11-16
CN102307573A (zh) 2012-01-04
US20150150810A1 (en) 2015-06-04
US20100285122A1 (en) 2010-11-11
AR075369A1 (es) 2011-03-30
CL2011001885A1 (es) 2012-05-25
EA030123B1 (ru) 2018-06-29
KR20110122729A (ko) 2011-11-10
HK1164737A1 (en) 2012-09-28
HUE025822T2 (en) 2016-04-28
BRPI1008664A2 (pt) 2016-03-08
CY1116852T1 (el) 2017-04-05
EA201491658A1 (ru) 2015-05-29
SI2393485T1 (sl) 2015-10-30
KR101645759B1 (ko) 2016-08-04
SG173544A1 (en) 2011-09-29
JP5611242B2 (ja) 2014-10-22
CN102307573B (zh) 2013-09-11
PL2393485T3 (pl) 2015-12-31
HRP20151009T1 (hr) 2015-10-23
AU2010210598A1 (en) 2011-08-25
DK2393485T3 (en) 2015-10-26
AP2011005857A0 (en) 2011-10-31
AU2010210598B2 (en) 2015-03-05
JP2012517432A (ja) 2012-08-02
EP2393485A2 (en) 2011-12-14
EA021313B1 (ru) 2015-05-29
SG10201706215UA (en) 2017-08-30
TWI444367B (zh) 2014-07-11
JP5911927B2 (ja) 2016-04-27
MX2011008289A (es) 2011-09-15
PE20110994A1 (es) 2012-01-24
KR20160093100A (ko) 2016-08-05
EP2393485B1 (en) 2015-07-29
SMT201500266B (it) 2016-01-08
EA201190125A1 (ru) 2012-01-30
WO2010091197A2 (en) 2010-08-12
PT2393485E (pt) 2015-10-23

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