ECSP088951A - /composición farmacéutica estable que contiene docetaxel y método para su fabricación - Google Patents
/composición farmacéutica estable que contiene docetaxel y método para su fabricaciónInfo
- Publication number
- ECSP088951A ECSP088951A EC2008008951A ECSP088951A ECSP088951A EC SP088951 A ECSP088951 A EC SP088951A EC 2008008951 A EC2008008951 A EC 2008008951A EC SP088951 A ECSP088951 A EC SP088951A EC SP088951 A ECSP088951 A EC SP088951A
- Authority
- EC
- Ecuador
- Prior art keywords
- pharmaceutical composition
- containing docetaxel
- stable pharmaceutical
- manufacturing
- composition containing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se relaciona con una composición farmacéutica estable para inyección que contiene docetaxel y un método de preparación de la misma. Más particularmente, la presente invención se relaciona con una composición farmacéutica para inyección que contiene docetaxel que tiene mejor estabilidad de almacenamiento que las medicaciones convencionales, que se prepara disolviendo el docetaxel, un compuesto insoluble en agua, en agua destilada después de mezclarlo con la ciclodextrina (CD) y un polímero soluble en agua, tal como metilcelulosa hidroxipropil (HPMC), glicol de polietileno (PEG ) o (PVP) y liofilizando la mezcla, y un método para prepararla.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20060045715 | 2006-05-22 | ||
KR1020070049340A KR100917809B1 (ko) | 2006-05-22 | 2007-05-21 | 우수한 저장안정성을 갖는 도세탁셀 함유 주사제 조성물 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP088951A true ECSP088951A (es) | 2009-02-27 |
Family
ID=39090946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2008008951A ECSP088951A (es) | 2006-05-22 | 2008-12-11 | /composición farmacéutica estable que contiene docetaxel y método para su fabricación |
Country Status (25)
Country | Link |
---|---|
US (1) | US8791152B2 (es) |
EP (1) | EP2019664B1 (es) |
JP (1) | JP5369332B2 (es) |
KR (2) | KR100917809B1 (es) |
CN (1) | CN101484137B (es) |
AU (1) | AU2007252371B2 (es) |
BR (1) | BRPI0711893A2 (es) |
CA (1) | CA2653124C (es) |
CR (1) | CR10485A (es) |
EA (1) | EA014071B1 (es) |
EC (1) | ECSP088951A (es) |
ES (1) | ES2560641T3 (es) |
GE (1) | GEP20115200B (es) |
GT (1) | GT200800257A (es) |
HK (1) | HK1128874A1 (es) |
IL (1) | IL195459A (es) |
MA (1) | MA30501B1 (es) |
MX (1) | MX2008014948A (es) |
MY (1) | MY149627A (es) |
NO (1) | NO20084932L (es) |
NZ (1) | NZ573202A (es) |
SV (1) | SV2008003106A (es) |
TN (1) | TNSN08475A1 (es) |
WO (1) | WO2007136219A1 (es) |
ZA (1) | ZA200809998B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101857900B1 (ko) | 2002-09-06 | 2018-05-14 | 인설트 테라페틱스, 인코퍼레이티드 | 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체 |
US20080176958A1 (en) | 2007-01-24 | 2008-07-24 | Insert Therapeutics, Inc. | Cyclodextrin-based polymers for therapeutics delivery |
CA2683712A1 (en) * | 2007-04-20 | 2009-01-15 | Sun Pharmaceutical Industries Limited | Pharmaceutical compositions |
KR101502533B1 (ko) * | 2007-11-22 | 2015-03-13 | 에스케이케미칼주식회사 | 우수한 안정성을 갖는 택산 유도체 함유 주사제용동결건조 조성물 및 이의 제조방법 |
DK2231144T3 (da) * | 2007-12-24 | 2014-10-13 | Sun Pharma Advanced Res Co Ltd | Nanodispersion |
KR101053780B1 (ko) * | 2008-02-29 | 2011-08-02 | 동아제약주식회사 | 도세탁셀을 함유하는 단일액상의 안정한 약제학적 조성물 |
CA2765541A1 (en) | 2009-06-19 | 2010-12-23 | Sun Pharma Advanced Research Company Ltd. | Nanodispersion of a drug and process for its preparation |
MX366955B (es) * | 2009-09-15 | 2019-07-31 | Bluelink Pharmaceuticals Inc | Crlx101 para usarse en el tratamiento de cáncer. |
BR112012012210B8 (pt) | 2009-11-23 | 2021-05-25 | Cerulean Pharma Inc | conjugado de (cdp)-taxano de polímero contendo ciclodextrina, composição, composição farmacêutica, forma de dosagem, kit e uso de um conjugado de cdp-taxano |
BR112012028037A2 (pt) | 2010-05-03 | 2016-08-02 | Teikoku Pharma Usa Inc | formulação de pró-emulsão líquida de taxano não aquosa, métodos para administrar um taxano a um paciente e para fabricar uma formulação de pró-emulsão de taxano, composição de emulsão de taxano, e, kit |
WO2012161520A2 (ko) * | 2011-05-23 | 2012-11-29 | 에스케이케미칼 주식회사 | 도세탁셀을 함유하는 액상 주사용 조성물 |
KR20120130740A (ko) * | 2011-05-23 | 2012-12-03 | 에스케이케미칼주식회사 | 도세탁셀을 함유하는 액상 주사용 조성물 |
JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
US20140094432A1 (en) | 2012-10-02 | 2014-04-03 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
EP2777691A1 (en) * | 2013-03-14 | 2014-09-17 | Pharmachemie B.V. | Taxoid - Purification of Liquid Excipients |
KR20140147336A (ko) * | 2013-06-19 | 2014-12-30 | 에스케이케미칼주식회사 | 도세탁셀을 함유하는 액상 주사용 조성물 |
KR20170012555A (ko) * | 2014-06-12 | 2017-02-02 | 더 유니버시티 오브 노트르 담 듀락 | 신경 질환 및 대뇌 상해의 치료를 위한 조성물 및 방법 |
WO2016149162A1 (en) | 2015-03-16 | 2016-09-22 | Meridian Lab | Pharmaceutical compositions containing taxane-cyclodextrin complexes, method of making and methods of use |
KR20180066239A (ko) * | 2015-10-20 | 2018-06-18 | 베. 브라운 멜중엔 악티엔게젤샤프트 | 단트롤렌을 포함하는 수성 조성물 |
WO2018047074A1 (en) * | 2016-09-07 | 2018-03-15 | Cadila Healthcare Limited | Sterile injectable compositions comprising drug micelles |
CN113559277B (zh) * | 2018-01-11 | 2023-11-17 | 比卡生物科技(广州)有限公司 | 一种注射用卡巴他赛组合物及其制备方法 |
CN110755371B (zh) * | 2018-07-25 | 2021-08-31 | 比卡生物科技(广州)有限公司 | 一种注射用多西他赛组合物及其制备方法 |
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AU2548992A (en) * | 1991-08-13 | 1993-03-16 | Temple University - Of The Commonwealth System Of Higher Education | Modulation of blood pressure and inhibition of platelet activation with kininogen fragment |
US5472954A (en) * | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
HUT73844A (en) * | 1994-11-11 | 1996-09-30 | Chinoin Gyogyszer Es Vegyeszet | New taxol complexes and pharmaceutical compositions containing them |
US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
GB9711643D0 (en) * | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
HUP9701945A3 (en) | 1997-11-10 | 2000-04-28 | Hexal Ag | Pharmaceutical composition for injection containing cyclodextrin and taxoids |
US6133473A (en) * | 1998-06-25 | 2000-10-17 | Rohm And Haas Company | Synthesis of carbamate compounds |
US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
KR100310839B1 (ko) | 1999-03-23 | 2001-10-12 | 정기련 | 안정성이 개선된 파크리탁셀 가용화 주사제 조성물 |
WO2000071163A1 (en) * | 1999-05-24 | 2000-11-30 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
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NZ516083A (en) * | 1999-05-27 | 2003-08-29 | Acusphere Inc | Porous drug matrices and methods of manufacture thereof |
US20030157161A1 (en) * | 2001-05-01 | 2003-08-21 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating inflammatory conditions utilizing protein or polysaccharide containing anti-microtubule agents |
CN1268321C (zh) * | 2001-07-13 | 2006-08-09 | 那野伽利阿株式会社 | 内部包有药物的高分子胶束的冻结干燥用组合物和该胶束的制备方法 |
KR20030041577A (ko) * | 2001-11-20 | 2003-05-27 | 디디에스텍주식회사 | 난용성 약물과 치환된 시클로덱스트린을 함유하는고체분산체 및 이를 함유하는 약제학적 조성물 |
JP2003342168A (ja) * | 2002-05-24 | 2003-12-03 | Nano Career Kk | 注射用薬物含有ポリマーミセル製剤の製造方法 |
AU2003257791A1 (en) * | 2002-08-15 | 2004-03-29 | Tong Liu | Soild nano pharmaceutical formulation and preparation method thereof |
CN1502332A (zh) * | 2002-11-25 | 2004-06-09 | 刘云清 | 抗癌药紫杉醇自乳化固体纳米粒——注射用紫杉醇的制备方法 |
US20040127551A1 (en) * | 2002-12-27 | 2004-07-01 | Kai Zhang | Taxane-based compositions and methods of use |
JP2005075783A (ja) | 2003-09-01 | 2005-03-24 | Otsuka Pharmaceut Factory Inc | 難溶性化合物の可溶化または分散化用組成物 |
EP1862183B1 (en) * | 2005-03-14 | 2010-11-03 | Otsuka Pharmaceutical Factory, Inc. | Kit comprising drug and fat emulsion |
-
2007
- 2007-05-21 KR KR1020070049340A patent/KR100917809B1/ko active IP Right Grant
- 2007-05-22 MY MYPI20084753A patent/MY149627A/en unknown
- 2007-05-22 EP EP07746627.4A patent/EP2019664B1/en active Active
- 2007-05-22 NZ NZ573202A patent/NZ573202A/en not_active IP Right Cessation
- 2007-05-22 CN CN200780024837.8A patent/CN101484137B/zh not_active Expired - Fee Related
- 2007-05-22 MX MX2008014948A patent/MX2008014948A/es active IP Right Grant
- 2007-05-22 GE GEAP200711018A patent/GEP20115200B/en unknown
- 2007-05-22 US US12/301,700 patent/US8791152B2/en not_active Expired - Fee Related
- 2007-05-22 BR BRPI0711893-7A patent/BRPI0711893A2/pt not_active IP Right Cessation
- 2007-05-22 JP JP2009511943A patent/JP5369332B2/ja not_active Expired - Fee Related
- 2007-05-22 CA CA2653124A patent/CA2653124C/en not_active Expired - Fee Related
- 2007-05-22 AU AU2007252371A patent/AU2007252371B2/en not_active Ceased
- 2007-05-22 EA EA200870559A patent/EA014071B1/ru not_active IP Right Cessation
- 2007-05-22 ES ES07746627.4T patent/ES2560641T3/es active Active
- 2007-05-22 WO PCT/KR2007/002479 patent/WO2007136219A1/en active Application Filing
-
2008
- 2008-11-21 TN TNP2008000475A patent/TNSN08475A1/en unknown
- 2008-11-21 GT GT200800257A patent/GT200800257A/es unknown
- 2008-11-23 IL IL195459A patent/IL195459A/en not_active IP Right Cessation
- 2008-11-24 SV SV2008003106A patent/SV2008003106A/es unknown
- 2008-11-25 ZA ZA200809998A patent/ZA200809998B/xx unknown
- 2008-11-25 NO NO20084932A patent/NO20084932L/no not_active Application Discontinuation
- 2008-12-05 MA MA31456A patent/MA30501B1/fr unknown
- 2008-12-09 CR CR10485A patent/CR10485A/es unknown
- 2008-12-11 EC EC2008008951A patent/ECSP088951A/es unknown
-
2009
- 2009-08-03 HK HK09107096.9A patent/HK1128874A1/zh not_active IP Right Cessation
- 2009-08-26 KR KR1020090079337A patent/KR100983376B1/ko active IP Right Grant
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