ES2625873T3 - Método de preparación de micropartículas biodegradables que contienen fármacos - Google Patents

Método de preparación de micropartículas biodegradables que contienen fármacos Download PDF

Info

Publication number
ES2625873T3
ES2625873T3 ES09803242.8T ES09803242T ES2625873T3 ES 2625873 T3 ES2625873 T3 ES 2625873T3 ES 09803242 T ES09803242 T ES 09803242T ES 2625873 T3 ES2625873 T3 ES 2625873T3
Authority
ES
Spain
Prior art keywords
drug
polymer
dispersion
containing microparticles
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09803242.8T
Other languages
English (en)
Inventor
Cherng-Ju Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Arkansas
Original Assignee
University of Arkansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Arkansas filed Critical University of Arkansas
Application granted granted Critical
Publication of ES2625873T3 publication Critical patent/ES2625873T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

Un método de preparación de micropartículas que contienen fármaco que comprende: disolver un polímero biodegradable en un disolvente orgánico para formar una solución de polímero; disolver o dispersar un fármaco en la solución de polímero para formar una fase polímero-fármaco-disolvente; mezclar la fase polímero-fármaco-disolvente con una suspensión acuosa que comprende un gel inorgánico para formar una dispersión que comprende gotitas de polímero-fármaco dispersas en la suspensión acuosa, donde el gel inorgánico puede disolverse mediante ácido; evaporar el disolvente orgánico de la dispersión para convertir las gotitas de polímero-fármaco en micropartículas que contienen fármaco; y recuperar las micropartículas que contienen fármaco de la dispersión, donde la etapa de recuperación de las micropartículas que contienen fármaco de la dispersión comprende añadir ácido a la dispersión para disolver el gel inorgánico.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6

Claims (1)

  1. imagen1
ES09803242.8T 2008-07-31 2009-07-23 Método de preparación de micropartículas biodegradables que contienen fármacos Active ES2625873T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US221096 2008-07-31
US12/221,096 US8034382B2 (en) 2008-07-31 2008-07-31 Preparation method for biodegradable micro-particles containing drugs
PCT/US2009/004273 WO2010014176A2 (en) 2008-07-31 2009-07-23 Preparation method of biodegradable micro-particles containing drugs

Publications (1)

Publication Number Publication Date
ES2625873T3 true ES2625873T3 (es) 2017-07-20

Family

ID=41608618

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09803242.8T Active ES2625873T3 (es) 2008-07-31 2009-07-23 Método de preparación de micropartículas biodegradables que contienen fármacos

Country Status (13)

Country Link
US (1) US8034382B2 (es)
EP (1) EP2303237B1 (es)
JP (1) JP5513504B2 (es)
KR (1) KR101006667B1 (es)
CN (2) CN103054811B (es)
BR (1) BRPI0906184A2 (es)
CA (1) CA2718750C (es)
CL (1) CL2010000981A1 (es)
DE (1) DE112009001815B4 (es)
ES (1) ES2625873T3 (es)
GB (1) GB2474402B (es)
MX (1) MX2010010278A (es)
WO (1) WO2010014176A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2008072379A1 (ja) 2006-12-13 2010-03-25 富士フイルム株式会社 修飾された生体高分子の製造方法及び生体高分子の架橋方法
US8034382B2 (en) 2008-07-31 2011-10-11 The Board Of Trustees Of The University Of Arkansas Preparation method for biodegradable micro-particles containing drugs
KR101513812B1 (ko) * 2013-11-22 2015-04-20 가천대학교 산학협력단 소수성 약물 전달용 마이크로 구조체의 제조방법
KR101711445B1 (ko) * 2015-09-23 2017-03-02 서강대학교 산학협력단 서방형 약물 방출 콘텍트렌즈의 제조방법
KR102047983B1 (ko) * 2017-11-30 2019-11-22 주식회사 지투지바이오 안전성 및 저장 안정성이 향상된 생분해성 미립구의 제조방법
KR101936040B1 (ko) * 2018-04-23 2019-01-08 주식회사 씨트리 안정화된 단상 혼합액을 이용하는 생분해성 미립구의 제조방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US20070009605A1 (en) 1998-07-23 2007-01-11 Ignatious Francis X Encapsulation of water soluble peptides
WO2001010414A1 (en) * 1999-08-04 2001-02-15 Oakwood Laboratories L.L.C. Slow release microspheres
US6743446B2 (en) 1999-12-15 2004-06-01 The Ohio State University Research Foundation Methods for stabilizing biologically active agents encapsulated in biodegradable controlled-release polymers
KR100392501B1 (ko) * 2000-06-28 2003-07-22 동국제약 주식회사 다중 에멀젼법에 의한 서방출성 미립구의 제조방법
US20040180091A1 (en) 2003-03-13 2004-09-16 Chang-Yi Lin Carbonated hydroxyapatite-based microspherical composites for biomedical uses
WO2005072125A2 (en) 2004-01-16 2005-08-11 Massachusetts Institute Of Technology Composite materials for controlled release of water soluble products
WO2006123359A2 (en) * 2005-03-01 2006-11-23 Sun Pharmaceutical Industries Limited A process of making microspheres
US8034382B2 (en) 2008-07-31 2011-10-11 The Board Of Trustees Of The University Of Arkansas Preparation method for biodegradable micro-particles containing drugs

Also Published As

Publication number Publication date
DE112009001815A5 (de) 2012-03-15
CN103054811A (zh) 2013-04-24
JP2011529878A (ja) 2011-12-15
CN102159192A (zh) 2011-08-17
BRPI0906184A2 (pt) 2017-07-18
US20100028454A1 (en) 2010-02-04
WO2010014176A3 (en) 2010-04-22
CL2010000981A1 (es) 2011-02-11
EP2303237A2 (en) 2011-04-06
GB201101668D0 (en) 2011-03-16
MX2010010278A (es) 2010-11-30
KR101006667B1 (ko) 2011-01-10
KR20100101190A (ko) 2010-09-16
US8034382B2 (en) 2011-10-11
EP2303237A4 (en) 2013-11-20
DE112009001815B4 (de) 2017-03-16
EP2303237B1 (en) 2017-03-08
WO2010014176A2 (en) 2010-02-04
CN102159192B (zh) 2013-05-22
JP5513504B2 (ja) 2014-06-04
CA2718750A1 (en) 2010-02-04
DE112009001815T5 (de) 2012-01-12
CA2718750C (en) 2016-03-29
GB2474402A (en) 2011-04-13
CN103054811B (zh) 2014-08-06
GB2474402B (en) 2011-06-29

Similar Documents

Publication Publication Date Title
ES2625873T3 (es) Método de preparación de micropartículas biodegradables que contienen fármacos
Hirst et al. Two-component dendritic gels: easily tunable materials
Das et al. Design of a pectin-based microparticle formulation using zinc ions as the cross-linking agent and glutaraldehyde as the hardening agent for colonic-specific delivery of resveratrol: in vitro and in vivo evaluations
EA201270050A1 (ru) Нанодисперсия лекарственного средства и способ ее получения
ES2528924T3 (es) Formulación para el cuidado de heridas
CL2011000393A1 (es) Metodo para preparar una microesfera de liberacion sostenidaque comprende disolver la sustancia activa y un polimero biodegradable en solvente acuoso y no acuoso respectivamente, formar una emulsion entre ambas soluciones, adicionarle un cosolvente y agregarla a un solvente acuoso para formar la microesfera y remover el solvente organico.
CO6190545A2 (es) Metodo de preparacion de microcapsulas de liberacion sostenida que tiene buena propiedad que inhibe el quebramiento inicial y de esta manera las microcapsulas
AR072359A1 (es) Encapsulacion de agentes biologicamente activos
AR063468A1 (es) Composiciones farmaceuticas
UY32761A (es) Preparaciones termoestables y preparaciones insulinicas estables a las vibraciones
BRPI0516772A (pt) formulação sólida com solubilidade e estabilidade melhoradas e método para produção da referida formulação
ECSP10010184A (es) Producto de dispersión sólida que contiene un compuesto a base de n-aril-urea
MX362709B (es) Microesferas de buprenorfina de fuerte carga de medicamento y su método de fabricación.
RU2016101418A (ru) Получение полилактидно-полигликолидных микрочастиц, характеризующихся сигмоидальным профилем высвобождения
JP2017507895A5 (es)
AR125407A2 (es) Procedimiento para la preparación de partículas de polímero farmacéuticas y/o cosméticas, y procedimiento para la preparación de composiciones farmacéuticas y/o cosméticas que comprenden dichas partículas
BR112016002342A2 (pt) Microesfera entecavir, método para preparação de uma microesfera entecavir, e, composição farmacêutica
EP2679253A3 (en) Medical devices based on cellulose
BRPI0418294A (pt) composições sólidas farmacêuticas estabilizadas de medicamentos de baixa solubilidade, poloxámeros e polìmeros estabilizantes
DOP2010000117A (es) Producto de dispersion solida de drogas basadas en n-aril urea
AR064104A1 (es) Formas de dosificacion en microemulsion de valsartan, y metodos para elaborarlas
AR053023A1 (es) Base libre de lercanidipina, metodos para su preparacion y composiciones farmaceuticas que las contienen
EA200900531A1 (ru) Фармацевтические составы
Pu et al. Microparticles and microcapsules from the solvent extraction of deep eutectic solvent-based emulsion
Zhang et al. Supramolecular Gels ofCholic Acids and Their Derivatives