ECSP045097A - Benzamida y heteroarilamida como antagonistas del receptor p2x7 - Google Patents

Benzamida y heteroarilamida como antagonistas del receptor p2x7

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Publication number
ECSP045097A
ECSP045097A EC2004005097A ECSP045097A ECSP045097A EC SP045097 A ECSP045097 A EC SP045097A EC 2004005097 A EC2004005097 A EC 2004005097A EC SP045097 A ECSP045097 A EC SP045097A EC SP045097 A ECSP045097 A EC SP045097A
Authority
EC
Ecuador
Prior art keywords
heteroarilamide
benzamide
antagonists
receiver
inhibitors
Prior art date
Application number
EC2004005097A
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English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ECSP045097A publication Critical patent/ECSP045097A/es

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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La presente invención se refiere a nuevos inhibidores de P2X7 de fórmula I (consta gráfico) y a procesos para su preparación, a intermedios útiles en su preparación, a composiciones farmacéuticas que los contienen y a su uso en terapia. Los compuestos activos de la presente invención son potentes inhibidores de P2X7, y como tales son útiles en el tratamiento de la inflamación, osteoartritis, artritis reumatoide, cáncer, reperfusión o isquemia en la apoplejía o infarto de miocardio, enfermedades autoinmunes y otros trastornos.
EC2004005097A 2001-11-12 2004-05-06 Benzamida y heteroarilamida como antagonistas del receptor p2x7 ECSP045097A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33678101P 2001-11-12 2001-11-12

Publications (1)

Publication Number Publication Date
ECSP045097A true ECSP045097A (es) 2004-06-28

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Application Number Title Priority Date Filing Date
EC2004005097A ECSP045097A (es) 2001-11-12 2004-05-06 Benzamida y heteroarilamida como antagonistas del receptor p2x7

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US (2) US7214677B2 (es)
EP (1) EP1448535B1 (es)
JP (1) JP4365218B2 (es)
KR (1) KR20050043785A (es)
CN (1) CN1585755A (es)
AP (1) AP2004003028A0 (es)
AR (1) AR038365A1 (es)
AT (1) ATE502020T1 (es)
BR (1) BR0214044A (es)
CA (1) CA2466724C (es)
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DE (1) DE60239485D1 (es)
DK (1) DK1448535T3 (es)
EA (1) EA200400488A1 (es)
EC (1) ECSP045097A (es)
ES (1) ES2358988T3 (es)
GT (1) GT200200224A (es)
HN (1) HN2002000319A (es)
HU (1) HUP0401936A3 (es)
IL (1) IL161329A0 (es)
IS (1) IS7216A (es)
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MX (1) MXPA04004465A (es)
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