ECSP024292A - Procedimiento para la preparacion de compuestos que contienen uno o mas enlaces amida, en particular peptidos - Google Patents

Procedimiento para la preparacion de compuestos que contienen uno o mas enlaces amida, en particular peptidos

Info

Publication number
ECSP024292A
ECSP024292A EC2002004292A ECSP024292A ECSP024292A EC SP024292 A ECSP024292 A EC SP024292A EC 2002004292 A EC2002004292 A EC 2002004292A EC SP024292 A ECSP024292 A EC SP024292A EC SP024292 A ECSP024292 A EC SP024292A
Authority
EC
Ecuador
Prior art keywords
preparation
procedure
compounds containing
amida
links
Prior art date
Application number
EC2002004292A
Other languages
English (en)
Inventor
Ivo Franci Eggen
Kortenaar Paulus Bernardus Ten
Original Assignee
Nv Organon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nv Organon filed Critical Nv Organon
Publication of ECSP024292A publication Critical patent/ECSP024292A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación de péptidos usando un exceso de un componente carboxílico activado para acilar un componente amino, donde después de la acilación, una amina que comprende un anión libre o un anión latente es usada como agente barredor de las funciones carboxílicas activadas residuales. Este procedimiento es útil para la producción de oligo- y polipéptidos y, más generalmente, para la preparación de compuestos que contienen uno o más enlaces amida.
EC2002004292A 2001-07-19 2002-07-19 Procedimiento para la preparacion de compuestos que contienen uno o mas enlaces amida, en particular peptidos ECSP024292A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01202751 2001-07-19

Publications (1)

Publication Number Publication Date
ECSP024292A true ECSP024292A (es) 2002-09-27

Family

ID=8180655

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2002004292A ECSP024292A (es) 2001-07-19 2002-07-19 Procedimiento para la preparacion de compuestos que contienen uno o mas enlaces amida, en particular peptidos

Country Status (24)

Country Link
US (2) US6864357B2 (es)
EP (1) EP1277761B1 (es)
JP (1) JP3579038B2 (es)
KR (1) KR100869520B1 (es)
CN (1) CN1254482C (es)
AR (1) AR035258A1 (es)
AT (1) ATE531724T1 (es)
AU (1) AU2002300166C1 (es)
BR (1) BRPI0202779B1 (es)
CA (1) CA2394216C (es)
DK (1) DK1277761T3 (es)
EC (1) ECSP024292A (es)
ES (1) ES2374389T3 (es)
HR (1) HRP20020608A2 (es)
HU (1) HUP0202370A2 (es)
IL (1) IL150600A (es)
MX (1) MXPA02006997A (es)
NO (1) NO326377B1 (es)
PE (1) PE20030215A1 (es)
PL (1) PL355126A1 (es)
RU (1) RU2242457C2 (es)
SG (1) SG120874A1 (es)
TW (1) TWI243826B (es)
ZA (1) ZA200205408B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL150601A (en) * 2001-07-19 2010-06-30 Organon Nv Process for rapid synthesis of peptides within a solution using the back of an activated carboxyl component and destruction of the residual activated carboxyl component
US7393277B2 (en) * 2003-08-25 2008-07-01 Igt Horseshoe payline system and games using that system
US7601061B2 (en) 2005-02-11 2009-10-13 Igt Gaming machine having independent spinning forms and multiple pay lines
EP1790656A1 (en) * 2005-11-25 2007-05-30 Nanokem S.A. Solution-phase synthesis of leuprolide
DK1979370T3 (da) * 2006-01-17 2010-06-28 Organon Nv Selektiv enzymatisk hydrolyse af C-terminale tert-butyl-ester peptider
JP4684124B2 (ja) * 2006-02-16 2011-05-18 富士通株式会社 移動局装置及び同装置における送信電力制御方法
WO2007099656A1 (ja) * 2006-03-01 2007-09-07 Kaneka Corporation ペプチドの製造方法
US7601062B2 (en) * 2006-11-06 2009-10-13 Igt Gaming device and method including moving paylines
US8124372B2 (en) * 2007-06-25 2012-02-28 N.V. Organon Selective enzymatic amidation of C-terminal esters or acids of peptides
EP2755690B1 (en) 2011-08-04 2020-04-01 Merck Sharp & Dohme B.V. Kisspeptide-pentasaccharide conjugates
US9177447B2 (en) 2012-09-25 2015-11-03 Igt Gaming system and method for providing a symbol matrix with a moveable symbol display window
ES2700973T3 (es) * 2014-02-14 2019-02-20 Corden Pharma Int Gmbh Proceso sin base para la preparación de compuestos intermedios de cetona que se pueden usar para fabricar nebivolol
CN115362144A (zh) * 2020-03-27 2022-11-18 株式会社钟化 含酰胺键化合物的制造方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221754A (en) * 1989-06-09 1993-06-22 Research Corporation Technologies, Inc. Reagents for rapid peptide synthesis
US5101059A (en) * 1989-12-05 1992-03-31 Research Corporation Technologies, Inc. Amino acid protecting groups
US5516892A (en) * 1992-12-28 1996-05-14 Indiana University Foundation Polymer-bound mixed carboxylic anhdrides as a stable form of activated carboxylic acids
US6310180B1 (en) * 1993-06-21 2001-10-30 Vanderbilt University Method for synthesis of proteins
US5516639A (en) * 1993-07-22 1996-05-14 Mayo Foundation For Medical Education And Research Antibodies specific for human prostate glandular kallkrein
US6001966A (en) * 1995-10-19 1999-12-14 Proligo Llc Method for solution phase synthesis of oligonucleotides and peptides
US5698676A (en) * 1995-11-30 1997-12-16 Abbott Laboratories Use of propylene oxide as an acid scavenger in peptide synthesis
US5849954A (en) * 1996-01-18 1998-12-15 Research Corporation Technologies, Inc. Method of peptide synthesis
NZ332116A (en) * 1996-05-03 2000-06-23 Warner Lambert Co Rapid purification of synthetic intermediates and products by polymer supported quench reagents
US6121488A (en) * 1997-09-24 2000-09-19 Warner-Lambert Company Quenching reagents for solution phase synthesis
JPH11217397A (ja) * 1997-11-27 1999-08-10 Saburo Aimoto ペプチドチオールエステルの製造方法
FR2780061B1 (fr) * 1998-06-22 2001-09-07 Rhone Poulenc Rorer Sa Nouveau procede de preparation de derives de cyclosporine
AU6951400A (en) * 1999-05-06 2000-12-12 Human Genome Sciences, Inc. Fibroblast growth factor 13
WO2000071569A1 (en) * 1999-05-26 2000-11-30 Abbott Laboratories Minimal isolation peptide synthesis process using ion-exchange resins as scavenging agents
US20020127219A1 (en) * 1999-12-30 2002-09-12 Okkels Jens Sigurd Lysosomal enzymes and lysosomal enzyme activators
CA2410898A1 (en) * 2000-07-19 2002-01-24 Pharmacia & Upjohn Company Substrates and assays for .beta.-secretase activity

Also Published As

Publication number Publication date
DK1277761T3 (da) 2012-02-20
NO326377B1 (no) 2008-11-17
MXPA02006997A (es) 2003-07-14
JP3579038B2 (ja) 2004-10-20
KR20030009187A (ko) 2003-01-29
PL355126A1 (en) 2003-01-27
ZA200205408B (en) 2002-09-05
IL150600A (en) 2005-09-25
US20030018163A1 (en) 2003-01-23
KR100869520B1 (ko) 2008-11-19
CN1254482C (zh) 2006-05-03
NO20023445D0 (no) 2002-07-18
HUP0202370A2 (hu) 2003-10-28
ATE531724T1 (de) 2011-11-15
HK1050905A1 (en) 2003-07-11
US6864357B2 (en) 2005-03-08
HU0202370D0 (es) 2002-09-28
SG120874A1 (en) 2006-04-26
HRP20020608A2 (en) 2003-02-28
IL150600A0 (en) 2003-02-12
ES2374389T3 (es) 2012-02-16
BR0202779A (pt) 2003-05-13
EP1277761B1 (en) 2011-11-02
RU2242457C2 (ru) 2004-12-20
TWI243826B (en) 2005-11-21
NO20023445L (no) 2003-01-20
US20050101764A1 (en) 2005-05-12
CA2394216C (en) 2009-11-03
EP1277761A3 (en) 2007-04-11
CA2394216A1 (en) 2003-01-19
PE20030215A1 (es) 2003-03-17
EP1277761A2 (en) 2003-01-22
CN1398875A (zh) 2003-02-26
BRPI0202779B1 (pt) 2016-01-05
AU2002300166B2 (en) 2005-02-17
AR035258A1 (es) 2004-05-05
RU2002119631A (ru) 2004-01-20
JP2003073396A (ja) 2003-03-12
AU2002300166C1 (en) 2006-04-13

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