HUP0202370A2 - Eljárás peptidek előállítására - Google Patents

Eljárás peptidek előállítására

Info

Publication number
HUP0202370A2
HUP0202370A2 HU0202370A HUP0202370A HUP0202370A2 HU P0202370 A2 HUP0202370 A2 HU P0202370A2 HU 0202370 A HU0202370 A HU 0202370A HU P0202370 A HUP0202370 A HU P0202370A HU P0202370 A2 HUP0202370 A2 HU P0202370A2
Authority
HU
Hungary
Prior art keywords
carboxylic acid
activated carboxylic
peptides
preparation
anion
Prior art date
Application number
HU0202370A
Other languages
English (en)
Inventor
Ivo Franci Eggen
Paulus Bernardus Wilhelmus Ten Kortenaar
Original Assignee
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.
Publication of HU0202370D0 publication Critical patent/HU0202370D0/hu
Publication of HUP0202370A2 publication Critical patent/HUP0202370A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány tárgya eljárás egy vagy több amidkötést tartalmazóvegyületek előállítására az amin komponens acilezésére aktiváltkarbonsav komponens feleslegben való alkalmazásával oly módon, hogy azacilálás után a maradék aktivált karbonsavcsoportok megkötésére egyszabad aniont vagy latens aniont tartalmazó aminvegyületetalkalmaznak. Ó
HU0202370A 2001-07-19 2002-07-18 Eljárás peptidek előállítására HUP0202370A2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01202751 2001-07-19

Publications (2)

Publication Number Publication Date
HU0202370D0 HU0202370D0 (hu) 2002-09-28
HUP0202370A2 true HUP0202370A2 (hu) 2003-10-28

Family

ID=8180655

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202370A HUP0202370A2 (hu) 2001-07-19 2002-07-18 Eljárás peptidek előállítására

Country Status (25)

Country Link
US (2) US6864357B2 (hu)
EP (1) EP1277761B1 (hu)
JP (1) JP3579038B2 (hu)
KR (1) KR100869520B1 (hu)
CN (1) CN1254482C (hu)
AR (1) AR035258A1 (hu)
AT (1) ATE531724T1 (hu)
AU (1) AU2002300166C1 (hu)
BR (1) BRPI0202779B1 (hu)
CA (1) CA2394216C (hu)
DK (1) DK1277761T3 (hu)
EC (1) ECSP024292A (hu)
ES (1) ES2374389T3 (hu)
HK (1) HK1050905A1 (hu)
HR (1) HRP20020608A2 (hu)
HU (1) HUP0202370A2 (hu)
IL (1) IL150600A (hu)
MX (1) MXPA02006997A (hu)
NO (1) NO326377B1 (hu)
PE (1) PE20030215A1 (hu)
PL (1) PL355126A1 (hu)
RU (1) RU2242457C2 (hu)
SG (1) SG120874A1 (hu)
TW (1) TWI243826B (hu)
ZA (1) ZA200205408B (hu)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI247012B (en) * 2001-07-19 2006-01-11 Akzo Nobel Nv Process for rapid solution synthesis of peptides
US7393277B2 (en) * 2003-08-25 2008-07-01 Igt Horseshoe payline system and games using that system
EP1790656A1 (en) 2005-11-25 2007-05-30 Nanokem S.A. Solution-phase synthesis of leuprolide
ATE461208T1 (de) * 2006-01-17 2010-04-15 Organon Nv Selektive enzymatische hydrolyse von c-terminalen tert-butyl-peptidestern
JP4684124B2 (ja) * 2006-02-16 2011-05-18 富士通株式会社 移動局装置及び同装置における送信電力制御方法
ES2729197T3 (es) 2006-03-01 2019-10-30 Kaneka Corp Método de producción de péptidos
US7601062B2 (en) * 2006-11-06 2009-10-13 Igt Gaming device and method including moving paylines
US8124372B2 (en) * 2007-06-25 2012-02-28 N.V. Organon Selective enzymatic amidation of C-terminal esters or acids of peptides
EP2755690B1 (en) 2011-08-04 2020-04-01 Merck Sharp & Dohme B.V. Kisspeptide-pentasaccharide conjugates
US9177447B2 (en) 2012-09-25 2015-11-03 Igt Gaming system and method for providing a symbol matrix with a moveable symbol display window
PT2907809T (pt) * 2014-02-14 2019-01-16 Corden Pharma Int Gmbh Processo sem base para a preparação de intermediários de cetona utilizáveis para fabrico de nebivolol
CN115362144A (zh) * 2020-03-27 2022-11-18 株式会社钟化 含酰胺键化合物的制造方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221754A (en) * 1989-06-09 1993-06-22 Research Corporation Technologies, Inc. Reagents for rapid peptide synthesis
US5101059A (en) * 1989-12-05 1992-03-31 Research Corporation Technologies, Inc. Amino acid protecting groups
US5516892A (en) * 1992-12-28 1996-05-14 Indiana University Foundation Polymer-bound mixed carboxylic anhdrides as a stable form of activated carboxylic acids
US6310180B1 (en) * 1993-06-21 2001-10-30 Vanderbilt University Method for synthesis of proteins
US5516639A (en) * 1993-07-22 1996-05-14 Mayo Foundation For Medical Education And Research Antibodies specific for human prostate glandular kallkrein
US5849954A (en) * 1996-01-18 1998-12-15 Research Corporation Technologies, Inc. Method of peptide synthesis
NZ332116A (en) * 1996-05-03 2000-06-23 Warner Lambert Co Rapid purification of synthetic intermediates and products by polymer supported quench reagents
US6121488A (en) * 1997-09-24 2000-09-19 Warner-Lambert Company Quenching reagents for solution phase synthesis
JPH11217397A (ja) * 1997-11-27 1999-08-10 Saburo Aimoto ペプチドチオールエステルの製造方法
FR2780061B1 (fr) * 1998-06-22 2001-09-07 Rhone Poulenc Rorer Sa Nouveau procede de preparation de derives de cyclosporine
WO2000071567A2 (en) * 1999-05-06 2000-11-30 Human Genome Sciences, Inc. Fibroblast growth factor 13
MXPA01012082A (es) * 1999-05-26 2002-07-22 Abbott Lab Proceso de sintesis de peptidos de aislamiento minimo, usando resinas de intercambio de iones como agentes depuradores.
US20020127219A1 (en) * 1999-12-30 2002-09-12 Okkels Jens Sigurd Lysosomal enzymes and lysosomal enzyme activators
DE60134230D1 (de) * 2000-07-19 2008-07-10 Pharmacia & Upjohn Co Llc Substraten und nachweise zur wirksamkeit von beta-secretase

Also Published As

Publication number Publication date
HU0202370D0 (hu) 2002-09-28
US6864357B2 (en) 2005-03-08
ATE531724T1 (de) 2011-11-15
CN1398875A (zh) 2003-02-26
AU2002300166C1 (en) 2006-04-13
US20030018163A1 (en) 2003-01-23
ZA200205408B (en) 2002-09-05
TWI243826B (en) 2005-11-21
MXPA02006997A (es) 2003-07-14
JP3579038B2 (ja) 2004-10-20
AR035258A1 (es) 2004-05-05
NO20023445L (no) 2003-01-20
EP1277761A2 (en) 2003-01-22
SG120874A1 (en) 2006-04-26
NO20023445D0 (no) 2002-07-18
NO326377B1 (no) 2008-11-17
ES2374389T3 (es) 2012-02-16
RU2002119631A (ru) 2004-01-20
HK1050905A1 (en) 2003-07-11
BR0202779A (pt) 2003-05-13
RU2242457C2 (ru) 2004-12-20
CA2394216A1 (en) 2003-01-19
US20050101764A1 (en) 2005-05-12
CA2394216C (en) 2009-11-03
ECSP024292A (es) 2002-09-27
AU2002300166B2 (en) 2005-02-17
PL355126A1 (en) 2003-01-27
BRPI0202779B1 (pt) 2016-01-05
CN1254482C (zh) 2006-05-03
KR20030009187A (ko) 2003-01-29
IL150600A0 (en) 2003-02-12
EP1277761A3 (en) 2007-04-11
JP2003073396A (ja) 2003-03-12
HRP20020608A2 (en) 2003-02-28
DK1277761T3 (da) 2012-02-20
PE20030215A1 (es) 2003-03-17
IL150600A (en) 2005-09-25
EP1277761B1 (en) 2011-11-02
KR100869520B1 (ko) 2008-11-19

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: N.V. ORGANON, NL

Free format text: FORMER OWNER(S): AKZO NOBEL N.V., NL

FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished