EA202190076A1 - Производные бензодиазепина, композиции и способы лечения когнитивных нарушений - Google Patents

Производные бензодиазепина, композиции и способы лечения когнитивных нарушений

Info

Publication number
EA202190076A1
EA202190076A1 EA202190076A EA202190076A EA202190076A1 EA 202190076 A1 EA202190076 A1 EA 202190076A1 EA 202190076 A EA202190076 A EA 202190076A EA 202190076 A EA202190076 A EA 202190076A EA 202190076 A1 EA202190076 A1 EA 202190076A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
cognitive impairment
gabaa receptor
compositions
derivatives
Prior art date
Application number
EA202190076A
Other languages
English (en)
Russian (ru)
Inventor
Белью Меконнен
Джон А. Батера
Цзяньсин Хуан
Хемантбхай Пател
Цинь Цзян
Роберт Джейсон Херр
Николас Джеймс Мейхью
Эмили Элизабет Фриман
Original Assignee
Эйджинбайо, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эйджинбайо, Инк. filed Critical Эйджинбайо, Инк.
Publication of EA202190076A1 publication Critical patent/EA202190076A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA202190076A 2018-06-19 2019-06-19 Производные бензодиазепина, композиции и способы лечения когнитивных нарушений EA202190076A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862687195P 2018-06-19 2018-06-19
PCT/US2019/038038 WO2019246300A1 (en) 2018-06-19 2019-06-19 Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment

Publications (1)

Publication Number Publication Date
EA202190076A1 true EA202190076A1 (ru) 2021-09-22

Family

ID=68984202

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190076A EA202190076A1 (ru) 2018-06-19 2019-06-19 Производные бензодиазепина, композиции и способы лечения когнитивных нарушений

Country Status (11)

Country Link
US (2) US11414425B2 (enExample)
EP (1) EP3810611A4 (enExample)
JP (1) JP7514534B2 (enExample)
CN (1) CN112601749B (enExample)
AU (1) AU2019288382B2 (enExample)
BR (1) BR112020026062B1 (enExample)
CA (1) CA3104478A1 (enExample)
EA (1) EA202190076A1 (enExample)
IL (1) IL279530B2 (enExample)
MX (1) MX2020013927A (enExample)
WO (1) WO2019246300A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ760341A (en) 2013-12-20 2021-12-24 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
MX392119B (es) 2015-06-19 2025-03-11 Agenebio Inc Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo
US11505555B2 (en) * 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN112601749B (zh) 2018-06-19 2024-03-26 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法
JP7737721B2 (ja) * 2019-12-19 2025-09-11 エージンバイオ， インコーポレイテッド 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法
CN116075302A (zh) * 2020-07-10 2023-05-05 艾吉因生物股份有限公司 GABAAα5激动剂和SV2A抑制剂的组合以及在认知损害的治疗中的使用方法
WO2022011314A1 (en) * 2020-07-10 2022-01-13 Agenebio, Inc. POLYMORPHS OF A GABAA α5 AGONIST AND METHODS OF USING IN THE TREATMENT OF COGNITIVE IMPAIRMENT
US20260033761A1 (en) 2022-07-29 2026-02-05 Hoffmann-La Roche Inc. Characterisation of neurological dysfunction
CN120584115A (zh) 2022-08-19 2025-09-02 艾吉因生物股份有限公司 苯并氮杂䓬衍生物、组合物和用于治疗认知损害的方法
CN117756848A (zh) * 2023-11-30 2024-03-26 常州大学 一种th-302衍生物及其制备方法

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CN108567786A (zh) * 2017-03-10 2018-09-25 陈洪国 一种治疗溃疡性结肠炎的药物组合物
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CN112601749B (zh) 2018-06-19 2024-03-26 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法

Also Published As

Publication number Publication date
IL279530B1 (en) 2025-09-01
JP7514534B2 (ja) 2024-07-11
MX2020013927A (es) 2021-03-02
BR112020026062A2 (pt) 2021-03-23
US20200048268A1 (en) 2020-02-13
WO2019246300A1 (en) 2019-12-26
NZ772066A (en) 2025-05-30
CA3104478A1 (en) 2019-12-26
AU2019288382A1 (en) 2021-02-11
EP3810611A1 (en) 2021-04-28
EP3810611A4 (en) 2022-03-30
US20230107032A1 (en) 2023-04-06
AU2019288382B2 (en) 2024-07-25
US11414425B2 (en) 2022-08-16
IL279530A (en) 2021-01-31
CN112601749A (zh) 2021-04-02
US12291535B2 (en) 2025-05-06
IL279530B2 (en) 2026-01-01
BR112020026062B1 (pt) 2023-04-04
JP2021528427A (ja) 2021-10-21
CN112601749B (zh) 2024-03-26

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