BR112020026062B1 - Compostos derivados de benzodiazepina ou um sal farmaceuticamente aceitavel, isômero ou combinação dos mesmos, composição farmacêutica compreendendo os mesmos e usos dos mesmos para o tratamento de comprometimento cognitivo, câncer cerebral e psicose da doença de parkinson - Google Patents

Compostos derivados de benzodiazepina ou um sal farmaceuticamente aceitavel, isômero ou combinação dos mesmos, composição farmacêutica compreendendo os mesmos e usos dos mesmos para o tratamento de comprometimento cognitivo, câncer cerebral e psicose da doença de parkinson Download PDF

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Publication number
BR112020026062B1
BR112020026062B1 BR112020026062-2A BR112020026062A BR112020026062B1 BR 112020026062 B1 BR112020026062 B1 BR 112020026062B1 BR 112020026062 A BR112020026062 A BR 112020026062A BR 112020026062 B1 BR112020026062 B1 BR 112020026062B1
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BR
Brazil
Prior art keywords
alkyl
aryl
occurrence
independently
aliphatic
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BR112020026062-2A
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English (en)
Portuguese (pt)
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BR112020026062A2 (pt
Inventor
Belew Mekonnen
John A. Butera
Jianxing Huang
Hemantbhai Patel
Qin Jiang
Robert Jason Herr
Nicholas James Mayhew
Emily Elizabeth Freeman
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Agenebio, Inc
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Publication of BR112020026062A2 publication Critical patent/BR112020026062A2/pt
Publication of BR112020026062B1 publication Critical patent/BR112020026062B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112020026062-2A 2018-06-19 2019-06-19 Compostos derivados de benzodiazepina ou um sal farmaceuticamente aceitavel, isômero ou combinação dos mesmos, composição farmacêutica compreendendo os mesmos e usos dos mesmos para o tratamento de comprometimento cognitivo, câncer cerebral e psicose da doença de parkinson BR112020026062B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862687195P 2018-06-19 2018-06-19
US62/687,195 2018-06-19
PCT/US2019/038038 WO2019246300A1 (en) 2018-06-19 2019-06-19 Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment

Publications (2)

Publication Number Publication Date
BR112020026062A2 BR112020026062A2 (pt) 2021-03-23
BR112020026062B1 true BR112020026062B1 (pt) 2023-04-04

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BR112020026062-2A BR112020026062B1 (pt) 2018-06-19 2019-06-19 Compostos derivados de benzodiazepina ou um sal farmaceuticamente aceitavel, isômero ou combinação dos mesmos, composição farmacêutica compreendendo os mesmos e usos dos mesmos para o tratamento de comprometimento cognitivo, câncer cerebral e psicose da doença de parkinson

Country Status (11)

Country Link
US (2) US11414425B2 (enExample)
EP (1) EP3810611A4 (enExample)
JP (1) JP7514534B2 (enExample)
CN (1) CN112601749B (enExample)
AU (1) AU2019288382B2 (enExample)
BR (1) BR112020026062B1 (enExample)
CA (1) CA3104478A1 (enExample)
EA (1) EA202190076A1 (enExample)
IL (1) IL279530B2 (enExample)
MX (1) MX2020013927A (enExample)
WO (1) WO2019246300A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ760341A (en) 2013-12-20 2021-12-24 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
MX392119B (es) 2015-06-19 2025-03-11 Agenebio Inc Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo
US11505555B2 (en) * 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN112601749B (zh) 2018-06-19 2024-03-26 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法
JP7737721B2 (ja) * 2019-12-19 2025-09-11 エージンバイオ， インコーポレイテッド 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法
CN116075302A (zh) * 2020-07-10 2023-05-05 艾吉因生物股份有限公司 GABAAα5激动剂和SV2A抑制剂的组合以及在认知损害的治疗中的使用方法
WO2022011314A1 (en) * 2020-07-10 2022-01-13 Agenebio, Inc. POLYMORPHS OF A GABAA α5 AGONIST AND METHODS OF USING IN THE TREATMENT OF COGNITIVE IMPAIRMENT
US20260033761A1 (en) 2022-07-29 2026-02-05 Hoffmann-La Roche Inc. Characterisation of neurological dysfunction
CN120584115A (zh) 2022-08-19 2025-09-02 艾吉因生物股份有限公司 苯并氮杂䓬衍生物、组合物和用于治疗认知损害的方法
CN117756848A (zh) * 2023-11-30 2024-03-26 常州大学 一种th-302衍生物及其制备方法

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CN108567786A (zh) * 2017-03-10 2018-09-25 陈洪国 一种治疗溃疡性结肠炎的药物组合物
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CN112601749B (zh) 2018-06-19 2024-03-26 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法

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IL279530B1 (en) 2025-09-01
JP7514534B2 (ja) 2024-07-11
MX2020013927A (es) 2021-03-02
BR112020026062A2 (pt) 2021-03-23
US20200048268A1 (en) 2020-02-13
WO2019246300A1 (en) 2019-12-26
NZ772066A (en) 2025-05-30
CA3104478A1 (en) 2019-12-26
AU2019288382A1 (en) 2021-02-11
EP3810611A1 (en) 2021-04-28
EP3810611A4 (en) 2022-03-30
US20230107032A1 (en) 2023-04-06
AU2019288382B2 (en) 2024-07-25
US11414425B2 (en) 2022-08-16
IL279530A (en) 2021-01-31
EA202190076A1 (ru) 2021-09-22
CN112601749A (zh) 2021-04-02
US12291535B2 (en) 2025-05-06
IL279530B2 (en) 2026-01-01
JP2021528427A (ja) 2021-10-21
CN112601749B (zh) 2024-03-26

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