MX2023000405A - Combinaciones de agonistas del receptor a del acido gamma aminobutirico (gabaa) alfa 5 e inhibidores de la glicoproteina de vesicula sinaptica 2a (sv2a) y metodos de uso en el tratamiento del deterioro cognitivo. - Google Patents

Combinaciones de agonistas del receptor a del acido gamma aminobutirico (gabaa) alfa 5 e inhibidores de la glicoproteina de vesicula sinaptica 2a (sv2a) y metodos de uso en el tratamiento del deterioro cognitivo.

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Publication number
MX2023000405A
MX2023000405A MX2023000405A MX2023000405A MX2023000405A MX 2023000405 A MX2023000405 A MX 2023000405A MX 2023000405 A MX2023000405 A MX 2023000405A MX 2023000405 A MX2023000405 A MX 2023000405A MX 2023000405 A MX2023000405 A MX 2023000405A
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Mexico
Prior art keywords
combinations
cognitive impairment
pharmaceutical compositions
methods
treating
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MX2023000405A
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English (en)
Inventor
Michela Gallagher
Sharon Rosenzweig-Lipson
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Agenebio Inc
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Publication of MX2023000405A publication Critical patent/MX2023000405A/es

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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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Abstract

Esta invención se refiere a métodos, usos, combinaciones, composiciones farmacéuticas, combinaciones para uso y composiciones farmacéuticas para uso útiles para tratar el deterioro cognitivo asociado con trastornos del sistema nervioso central (SNC). En particular, se relaciona con el uso de inhibidores de la glicoproteína 2A de la vesícula sináptica (SV2A), en combinación con agonistas del receptor GABAA a5, en el tratamiento del deterioro cognitivo asociado con trastornos del sistema nervioso central (SNC) en un sujeto que lo necesite o esté en riesgo de sufrirlo, incluyendo, sin limitación, sujetos que tengan o estén en riesgo de tener deterioro cognitivo relacionado con la edad, deterioro cognitivo leve (DCL), DCL amnésico (DCLa), deterioro de la memoria asociado con la edad (AAMI), deterioro cognitivo relacionado con la edad (ARCD), demencia, enfermedad de Alzheimer (EA), EA prodrómica, trastorno de estrés postraumático (TEPT), esquizofrenia, trastorno bipolar, esclerosis lateral amiotrófica, deterioro cognitivo relacionado con la terapia del cáncer, retraso mental, enfermedad de Parkinson, autismo, conducta compulsiva y adicción a sustancias. Además, la invención se refiere a métodos, usos, combinaciones, composiciones farmacéuticas, combinaciones para uso y composiciones farmacéuticas para uso útiles para tratar el deterioro cognitivo asociado con cáncer cerebral o para tratar el propio cáncer cerebral en un sujeto que lo necesite. Además, la invención se refiere a métodos, usos, combinaciones, composiciones farmacéuticas, combinaciones para uso y composiciones farmacéuticas para uso útiles para tratar la psicosis de la enfermedad de Parkinson en un sujeto que lo necesite.
MX2023000405A 2020-07-10 2021-07-09 Combinaciones de agonistas del receptor a del acido gamma aminobutirico (gabaa) alfa 5 e inhibidores de la glicoproteina de vesicula sinaptica 2a (sv2a) y metodos de uso en el tratamiento del deterioro cognitivo. MX2023000405A (es)

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US202063050730P 2020-07-10 2020-07-10
PCT/US2021/041184 WO2022011318A1 (en) 2020-07-10 2021-07-09 Combinations of gabaa alpha 5 agonists and sv2a inhibitors and methods of using in the treatment of cognitive impairment

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US (2) US20220062296A1 (es)
EP (1) EP4178582A1 (es)
JP (1) JP2023534189A (es)
CN (1) CN116075302A (es)
AU (1) AU2021304356A1 (es)
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US20230098667A1 (en) * 2019-12-19 2023-03-30 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2023192686A1 (en) * 2022-04-01 2023-10-05 Li shi jiang Methods for preventing or slowing the progression of cognitive decline or impairment in subjects displaying normal cognitive performance
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

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