BR112023000423A2 - Combinações de agonistas gabaa alfa 5 e inibidores de sv2a e métodos de uso no tratamento de comprometimento cognitivo - Google Patents
Combinações de agonistas gabaa alfa 5 e inibidores de sv2a e métodos de uso no tratamento de comprometimento cognitivoInfo
- Publication number
- BR112023000423A2 BR112023000423A2 BR112023000423A BR112023000423A BR112023000423A2 BR 112023000423 A2 BR112023000423 A2 BR 112023000423A2 BR 112023000423 A BR112023000423 A BR 112023000423A BR 112023000423 A BR112023000423 A BR 112023000423A BR 112023000423 A2 BR112023000423 A2 BR 112023000423A2
- Authority
- BR
- Brazil
- Prior art keywords
- cognitive impairment
- treatment
- combinations
- methods
- agonists
- Prior art date
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Abstract
COMBINAÇÕES DE AGONISTAS GABAA ALFA 5 E INIBIDORES DE SV2A E MÉTODOS DE USO NO TRATAMENTO DE COMPROMETIMENTO COGNITIVO. Esta invenção refere-se a métodos usos, combinações, composições farmacêuticas, úteis para o tratamento de comprometimento cognitivo associado com distúrbios do sistema nervoso central (CNS). Em particular, refere-se ao uso de inibidores de glicoproteína 2A de vesicular sináptica (SV2A), em combinação com agonistas de receptor de GABAA a5, no tratamento de comprometimento cognitivo associado com distúrbios do sistema nervoso central (CNS) em um indivíduo em necessidade ou em risco do mesmo, incluindo indivíduos tendo ou em risco de comprometimento cognitivo relacionado com a idade, comprometimento cognitivo brando (MCI), MCl amnéstico (aMCI), comprometimento de memória associado com a idade (AAMI), declínio cognitivo relacionado com a idade (ARCD), demência, doença de Alzheimer (AD), AD prodromal, distúrbio do estresse pós-traumático (PTSD), esquizofrenia, distúrbio bipolar, esclerose lateral amiotrófica, comprometimento cognitivo relacionado com a terapia do câncer, retardo mental, doença de Parkinson, autismo, comportamento compulsivo, e adicção de substância. Além disso, a invenção refere-se a métodos, usos, combinações, composições farmacêuticas, úteis para o tratamento de comprometimento cognitivo associado com cancer cerebral ou para o tratamento do próprio câncer cerebral, ou para o tratamento de psicose da doença de Parkinson em um indivíduo em necessidade do mesmo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US202063050730P | 2020-07-10 | 2020-07-10 | |
PCT/US2021/041184 WO2022011318A1 (en) | 2020-07-10 | 2021-07-09 | Combinations of gabaa alpha 5 agonists and sv2a inhibitors and methods of using in the treatment of cognitive impairment |
Publications (1)
Publication Number | Publication Date |
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BR112023000423A2 true BR112023000423A2 (pt) | 2023-03-14 |
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BR112023000423A BR112023000423A2 (pt) | 2020-07-10 | 2021-07-09 | Combinações de agonistas gabaa alfa 5 e inibidores de sv2a e métodos de uso no tratamento de comprometimento cognitivo |
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US (2) | US20220062296A1 (pt) |
EP (1) | EP4178582A1 (pt) |
JP (1) | JP2023534189A (pt) |
CN (1) | CN116075302A (pt) |
AU (1) | AU2021304356A1 (pt) |
BR (1) | BR112023000423A2 (pt) |
CA (1) | CA3189302A1 (pt) |
IL (1) | IL299754A (pt) |
MX (1) | MX2023000405A (pt) |
WO (1) | WO2022011318A1 (pt) |
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US20230098667A1 (en) * | 2019-12-19 | 2023-03-30 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
WO2023192686A1 (en) * | 2022-04-01 | 2023-10-05 | Li shi jiang | Methods for preventing or slowing the progression of cognitive decline or impairment in subjects displaying normal cognitive performance |
WO2024039886A1 (en) | 2022-08-19 | 2024-02-22 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
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AU2009303834B2 (en) * | 2008-10-16 | 2016-08-11 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
CN102905532A (zh) * | 2010-02-09 | 2013-01-30 | 约翰斯.霍普金斯大学 | 用于改善认知功能的方法和组合物 |
CA2891122C (en) * | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
MX2016007808A (es) * | 2013-12-20 | 2016-09-07 | Agenebio Inc | Derivados de benzodiazepina, composiciones, y metodos para tratar el deterioro congnitivo. |
US20180170941A1 (en) * | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
WO2019246300A1 (en) * | 2018-06-19 | 2019-12-26 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
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2021
- 2021-07-09 JP JP2023501424A patent/JP2023534189A/ja active Pending
- 2021-07-09 EP EP21836970.0A patent/EP4178582A1/en active Pending
- 2021-07-09 CN CN202180062022.9A patent/CN116075302A/zh active Pending
- 2021-07-09 US US17/372,405 patent/US20220062296A1/en active Pending
- 2021-07-09 IL IL299754A patent/IL299754A/en unknown
- 2021-07-09 WO PCT/US2021/041184 patent/WO2022011318A1/en unknown
- 2021-07-09 CA CA3189302A patent/CA3189302A1/en active Pending
- 2021-07-09 MX MX2023000405A patent/MX2023000405A/es unknown
- 2021-07-09 BR BR112023000423A patent/BR112023000423A2/pt unknown
- 2021-07-09 US US18/015,439 patent/US20230270753A1/en active Pending
- 2021-07-09 AU AU2021304356A patent/AU2021304356A1/en active Pending
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IL299754A (en) | 2023-03-01 |
US20220062296A1 (en) | 2022-03-03 |
AU2021304356A1 (en) | 2023-02-23 |
US20230270753A1 (en) | 2023-08-31 |
CN116075302A (zh) | 2023-05-05 |
CA3189302A1 (en) | 2022-01-13 |
JP2023534189A (ja) | 2023-08-08 |
EP4178582A1 (en) | 2023-05-17 |
WO2022011318A1 (en) | 2022-01-13 |
MX2023000405A (es) | 2023-05-10 |
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