EA201990450A1 - Ингибиторы киназы, содержащей домен с двумя лейциновыми "застежками-молниями" (dlk), для лечения заболевания - Google Patents
Ингибиторы киназы, содержащей домен с двумя лейциновыми "застежками-молниями" (dlk), для лечения заболеванияInfo
- Publication number
- EA201990450A1 EA201990450A1 EA201990450A EA201990450A EA201990450A1 EA 201990450 A1 EA201990450 A1 EA 201990450A1 EA 201990450 A EA201990450 A EA 201990450A EA 201990450 A EA201990450 A EA 201990450A EA 201990450 A1 EA201990450 A1 EA 201990450A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- disease
- result
- dlk
- domain
- nervous system
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
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- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 102100025180 Mitogen-activated protein kinase kinase kinase 12 Human genes 0.000 abstract 3
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 208000010877 cognitive disease Diseases 0.000 abstract 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
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- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
В данном документе раскрыты соединения, которые подавляют киназную активность киназы, содержащей домен с двумя лейциновыми "застежками-молниями" (DLK) (MAP3K12), фармацевтические композиции и способы лечения заболеваний, опосредованных DLK, таких как неврологические заболевания, которые возникают в результате травматического повреждения нейронов центральной нервной системы и периферической нервной системы (например, инсульт, травматическое повреждение головного мозга, повреждение спинного мозга), или которые возникают в результате хронического нейродегенеративного состояния (например, болезни Альцгеймера, лобно-височной деменции, болезни Паркинсона, болезни Хантингтона, амиотрофического латерального склероза, спинально-церебеллярной атаксии, прогрессирующего надъядерного паралича, болезни телец Леви, болезни Кеннеди и других связанных с ними состояний), которые возникают в результате невропатий, возникающих в результате неврологического повреждения (периферическая невропатия, индуцированная химиотерапией, диабетическая невропатия и связанные с ними состояния), и которые возникают в результате когнитивных расстройств, обусловленных фармакологическим воздействием (например, когнитивного расстройства, индуцированного химиотериапией, также известного как "химический мозг").
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662380822P | 2016-08-29 | 2016-08-29 | |
| PCT/US2017/048941 WO2018044808A1 (en) | 2016-08-29 | 2017-08-28 | Inhibitors of dual leucine ziper (dlk) kinase for the treatment of disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201990450A1 true EA201990450A1 (ru) | 2019-07-31 |
Family
ID=61240329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201990450A EA201990450A1 (ru) | 2016-08-29 | 2017-08-28 | Ингибиторы киназы, содержащей домен с двумя лейциновыми "застежками-молниями" (dlk), для лечения заболевания |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20180057507A1 (ru) |
| EP (1) | EP3503889A1 (ru) |
| JP (1) | JP2019528319A (ru) |
| KR (1) | KR20190040068A (ru) |
| CN (1) | CN109789132A (ru) |
| AU (1) | AU2017321313A1 (ru) |
| BR (1) | BR112019004243A2 (ru) |
| CA (1) | CA3035195A1 (ru) |
| CL (1) | CL2019000534A1 (ru) |
| CO (1) | CO2019002839A2 (ru) |
| EA (1) | EA201990450A1 (ru) |
| EC (1) | ECSP19021843A (ru) |
| MX (1) | MX2019002444A (ru) |
| WO (1) | WO2018044808A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3045947A1 (en) | 2016-12-08 | 2018-06-14 | Michael J. Soth | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease |
| EP3897670A4 (en) | 2018-12-19 | 2022-09-07 | Disarm Therapeutics, Inc. | MRSA1 INHIBITORS IN COMBINATION WITH NEUROPROTECTIVE AGENTS |
| US11560366B2 (en) * | 2019-10-21 | 2023-01-24 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
| EP4208455A1 (en) | 2020-09-02 | 2023-07-12 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Lzk-targeting degraders and methods of use |
| CN117120052A (zh) * | 2020-10-13 | 2023-11-24 | 约翰斯·霍普金斯大学 | 取代的4-([1,2,4]三唑并[1,5-a]吡啶-6-基)噻吩-2-甲酰胺衍生物及其用途 |
| CN114605497B (zh) * | 2021-02-10 | 2023-04-28 | 北京欣安诚科技有限公司 | 一种dapk1磷酸化底物的人工小分子干扰肽及其制药用途 |
| EP4395899A1 (en) * | 2021-09-01 | 2024-07-10 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Mixed lineage kinase inhibitors and methods of use |
| CN115770239B (zh) * | 2022-12-05 | 2024-01-30 | 南京中医药大学 | 呋喃并色酮及药学上可接受的盐在制备治疗周围神经病变的药物中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1618119A2 (en) * | 2003-04-25 | 2006-01-25 | Chiron Corporation | Pyridyl substituted ketolide antibiotics |
| WO2004096823A2 (en) * | 2003-04-25 | 2004-11-11 | Chiron Corporation | Novel ketolide derivatives |
| TW200944520A (en) * | 2008-01-29 | 2009-11-01 | Glaxo Group Ltd | Spiro compounds as NPY Y5 receptor antagonists |
| FR2928923B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
| EP2651930B1 (en) * | 2010-12-16 | 2015-10-28 | Boehringer Ingelheim International GmbH | Biarylamide inhibitors of leukotriene production |
| BR112014026176A2 (pt) * | 2012-05-22 | 2017-06-27 | Hoffmann La Roche | dipiridilaminas substituídas e usos das mesmas |
| MX2015009270A (es) * | 2013-01-18 | 2015-10-30 | Hoffmann La Roche | Pirazoles sustituidos en posicion 3 y uso de los mismos como inhibidores de la cinasa cremallera de leucinas dual (dlk). |
| AR096151A1 (es) * | 2013-05-01 | 2015-12-09 | Hoffmann La Roche | Compuestos de biheteroarilo y usos de los mismos |
| MX2016008110A (es) * | 2013-12-20 | 2016-08-19 | Hoffmann La Roche | Derivados de pirazol como inhibidores de la cinasa de cremallera de leucina dual (dlk) y usos de los mismos. |
-
2017
- 2017-08-28 AU AU2017321313A patent/AU2017321313A1/en not_active Abandoned
- 2017-08-28 JP JP2019531562A patent/JP2019528319A/ja active Pending
- 2017-08-28 EP EP17847316.1A patent/EP3503889A1/en not_active Withdrawn
- 2017-08-28 EA EA201990450A patent/EA201990450A1/ru unknown
- 2017-08-28 KR KR1020197008981A patent/KR20190040068A/ko unknown
- 2017-08-28 BR BR112019004243A patent/BR112019004243A2/pt not_active Application Discontinuation
- 2017-08-28 MX MX2019002444A patent/MX2019002444A/es unknown
- 2017-08-28 WO PCT/US2017/048941 patent/WO2018044808A1/en active Application Filing
- 2017-08-28 CA CA3035195A patent/CA3035195A1/en not_active Abandoned
- 2017-08-28 US US15/688,554 patent/US20180057507A1/en not_active Abandoned
- 2017-08-28 CN CN201780057801.3A patent/CN109789132A/zh active Pending
-
2019
- 2019-02-28 CL CL2019000534A patent/CL2019000534A1/es unknown
- 2019-03-27 CO CONC2019/0002839A patent/CO2019002839A2/es unknown
- 2019-03-28 EC ECSENADI201921843A patent/ECSP19021843A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112019004243A2 (pt) | 2019-06-04 |
| CN109789132A (zh) | 2019-05-21 |
| WO2018044808A1 (en) | 2018-03-08 |
| CL2019000534A1 (es) | 2019-08-02 |
| ECSP19021843A (es) | 2019-05-31 |
| MX2019002444A (es) | 2019-09-02 |
| EP3503889A1 (en) | 2019-07-03 |
| US20180057507A1 (en) | 2018-03-01 |
| AU2017321313A1 (en) | 2019-03-21 |
| KR20190040068A (ko) | 2019-04-16 |
| CO2019002839A2 (es) | 2019-04-30 |
| CA3035195A1 (en) | 2018-03-08 |
| JP2019528319A (ja) | 2019-10-10 |
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