EA201691602A1 - Комбинация баклофена, акампросата и среднецепочечных триглицеридов для лечения неврологических расстройств - Google Patents

Комбинация баклофена, акампросата и среднецепочечных триглицеридов для лечения неврологических расстройств

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Publication number
EA201691602A1
EA201691602A1 EA201691602A EA201691602A EA201691602A1 EA 201691602 A1 EA201691602 A1 EA 201691602A1 EA 201691602 A EA201691602 A EA 201691602A EA 201691602 A EA201691602 A EA 201691602A EA 201691602 A1 EA201691602 A1 EA 201691602A1
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Eurasian Patent Office
Prior art keywords
disease
acamprosate
triggycerides
baclophene
neck
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EA201691602A
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English (en)
Inventor
Даниель Коэн
Илья Чумаков
Сергей Набирочкин
Родольф Хадж
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Фарнекст
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Publication of EA201691602A1 publication Critical patent/EA201691602A1/ru

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Neurology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение касается комбинаций и способов лечения неврологических заболеваний, связанных с токсичностью бета-амилоида, и/или гибелью нейронов, и/или нарушением метаболизма глюкозы в нейронах. Более конкретно, настоящее изобретение касается новой комбинированной терапии болезни Альцгеймера, родственных болезни Альцгеймера заболеваний, лобно-височной деменции, болезни Паркинсона, деменции с тельцами Леви, болезни Хантингтона, периферических невропатий, алкоголизма или алкогольной абстиненции, неврологических проявлений злоупотребления наркотиками или абстинентного синдрома, бокового амиотрофического склероза, рассеянного склероза, повреждения спинного мозга, эпилепсии, черепно-мозговой травмы или ишемии головного мозга на основе баклофена, акампросата и по меньшей мере одного среднецепочечного триглицерида.
EA201691602A 2014-02-11 2015-02-10 Комбинация баклофена, акампросата и среднецепочечных триглицеридов для лечения неврологических расстройств EA201691602A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461938340P 2014-02-11 2014-02-11
PCT/EP2015/052694 WO2015121218A1 (en) 2014-02-11 2015-02-10 Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disorders

Publications (1)

Publication Number Publication Date
EA201691602A1 true EA201691602A1 (ru) 2017-03-31

Family

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EA201691602A EA201691602A1 (ru) 2014-02-11 2015-02-10 Комбинация баклофена, акампросата и среднецепочечных триглицеридов для лечения неврологических расстройств

Country Status (12)

Country Link
US (1) US10905672B2 (ru)
EP (1) EP3104850A1 (ru)
JP (1) JP6619744B2 (ru)
KR (1) KR20160111013A (ru)
CN (1) CN106456583B (ru)
AU (1) AU2015217796B2 (ru)
CA (1) CA2938361A1 (ru)
EA (1) EA201691602A1 (ru)
IL (1) IL246856A0 (ru)
MX (1) MX2016010409A (ru)
SG (1) SG11201606275WA (ru)
WO (1) WO2015121218A1 (ru)

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Also Published As

Publication number Publication date
CA2938361A1 (en) 2015-08-20
WO2015121218A1 (en) 2015-08-20
AU2015217796B2 (en) 2020-04-30
CN106456583B (zh) 2020-04-07
US20160354335A1 (en) 2016-12-08
JP2017505786A (ja) 2017-02-23
MX2016010409A (es) 2016-11-30
AU2015217796A1 (en) 2016-08-18
JP6619744B2 (ja) 2019-12-11
US10905672B2 (en) 2021-02-02
EP3104850A1 (en) 2016-12-21
KR20160111013A (ko) 2016-09-23
IL246856A0 (en) 2016-08-31
CN106456583A (zh) 2017-02-22
SG11201606275WA (en) 2016-08-30

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