EA202092300A1 - ПРОИЗВОДНЫЕ ПИРРОЛИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ ОКСИТОЦИНА/ВАЗОПРЕССИНА V1a - Google Patents
ПРОИЗВОДНЫЕ ПИРРОЛИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ ОКСИТОЦИНА/ВАЗОПРЕССИНА V1aInfo
- Publication number
- EA202092300A1 EA202092300A1 EA202092300A EA202092300A EA202092300A1 EA 202092300 A1 EA202092300 A1 EA 202092300A1 EA 202092300 A EA202092300 A EA 202092300A EA 202092300 A EA202092300 A EA 202092300A EA 202092300 A1 EA202092300 A1 EA 202092300A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- vasopressin
- oxytocin
- antagonists
- receptors
- pyrrolidine derivatives
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
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- Reproductive Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Настоящее изобретение относится к соединению формулы O-метилоксим (3Z,5S)-5-(гидроксиметил)-1-[(2'-метил-1,1'-бифенил-4-ил)карбонил]пирролидин-3-она и/или активному метаболиту указанного соединения, обладающему антагонистическим действием на рецептор окситоцина и/или рецептор вазопрессина V1a, к способам их получения, фармацевтическим композициям, содержащим указанные соединения, и их применению.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13183723.9A EP2845850A1 (en) | 2013-09-10 | 2013-09-10 | Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists |
Publications (1)
Publication Number | Publication Date |
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EA202092300A1 true EA202092300A1 (ru) | 2021-06-30 |
Family
ID=49118429
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201690480A EA036830B1 (ru) | 2013-09-10 | 2014-07-25 | ПРИМЕНЕНИЕ ПРОИЗВОДНЫХ ПИРРОЛИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ ОКСИТОЦИНА/ВАЗОПРЕССИНА V1a ДЛЯ УЛУЧШЕНИЯ РЕЗУЛЬТАТОВ ПЕРЕНОСА ЭМБРИОНА У ПАЦИЕНТОВ, КОТОРЫЕ ПОДВЕРГАЮТСЯ ПРОЦЕДУРЕ ВСПОМОГАТЕЛЬНОЙ РЕПРОДУКТИВНОЙ ТЕХНОЛОГИИ |
EA202092300A EA202092300A1 (ru) | 2013-09-10 | 2014-07-25 | ПРОИЗВОДНЫЕ ПИРРОЛИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ ОКСИТОЦИНА/ВАЗОПРЕССИНА V1a |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201690480A EA036830B1 (ru) | 2013-09-10 | 2014-07-25 | ПРИМЕНЕНИЕ ПРОИЗВОДНЫХ ПИРРОЛИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ ОКСИТОЦИНА/ВАЗОПРЕССИНА V1a ДЛЯ УЛУЧШЕНИЯ РЕЗУЛЬТАТОВ ПЕРЕНОСА ЭМБРИОНА У ПАЦИЕНТОВ, КОТОРЫЕ ПОДВЕРГАЮТСЯ ПРОЦЕДУРЕ ВСПОМОГАТЕЛЬНОЙ РЕПРОДУКТИВНОЙ ТЕХНОЛОГИИ |
Country Status (23)
Country | Link |
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US (6) | US20160221944A1 (ru) |
EP (4) | EP2845850A1 (ru) |
JP (6) | JP2016529258A (ru) |
KR (3) | KR101804739B1 (ru) |
CN (4) | CN107674011A (ru) |
AU (3) | AU2014320694B2 (ru) |
BR (1) | BR112016005276B1 (ru) |
CA (2) | CA2921580C (ru) |
CY (1) | CY1120152T1 (ru) |
DK (1) | DK3044206T3 (ru) |
EA (2) | EA036830B1 (ru) |
ES (2) | ES2664403T3 (ru) |
HK (2) | HK1221716A1 (ru) |
HU (1) | HUE037578T2 (ru) |
IL (2) | IL244152A (ru) |
MX (1) | MX370602B (ru) |
PT (1) | PT3044206T (ru) |
SG (2) | SG11201601743RA (ru) |
SI (1) | SI3044206T1 (ru) |
TR (1) | TR201807175T4 (ru) |
UA (1) | UA115708C2 (ru) |
WO (1) | WO2015036160A1 (ru) |
ZA (1) | ZA201704072B (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2845850A1 (en) | 2013-09-10 | 2015-03-11 | ObsEva S.A. | Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists |
EP2886107A1 (en) | 2013-12-17 | 2015-06-24 | ObsEva S.A. | Oral formulations of pyrrolydine derivatives |
CN114105850A (zh) * | 2014-07-02 | 2022-03-01 | 奥布赛瓦股份公司 | 治疗ot-r活性相关的病症的方法中可用的晶体 |
AU2017205254B2 (en) | 2016-01-04 | 2021-05-20 | Xoma (Us) Lcc | Alpha-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof |
MX2018012351A (es) * | 2016-04-12 | 2019-02-07 | Trigemina Inc | Formulaciones de oxitocina que contienen magnesio y metodos de uso. |
MA52548A (fr) * | 2016-07-21 | 2021-05-26 | ObsEva SA | Régimes posologiques d'antagonistes de l'ocytocine pour favoriser l'implantation d'embryons et prévenir les fausses couches |
KR20220075340A (ko) | 2019-09-03 | 2022-06-08 | 옵스에파 에스에이 | 배아 착상을 촉진하고 유산을 예방하기 위한 옥시토신 길항제 투여 요법 |
CN115380122A (zh) | 2020-02-10 | 2022-11-22 | 奥布赛瓦股份公司 | 用于催产素受体拮抗剂疗法的生物标志物 |
RU2756027C1 (ru) * | 2021-02-24 | 2021-09-24 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта" | Способ диагностики наружного генитального эндометриоза |
WO2024073451A1 (en) * | 2022-09-30 | 2024-04-04 | Ocelot Bio, Inc. | Mixed vasopressin receptor agonist-antagonist for treating end-stage liver disease and complications associated thereof |
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YU120988A (en) | 1988-06-23 | 1990-06-30 | Lek Tovarna Farmacevtskih | Process for preparing new dispersion pills of cimetidine |
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YU183988A (en) | 1988-09-30 | 1990-08-31 | Lek Tovarna Farmacevtskih | Process for preparing dispersion pills of dihydroergotoxine |
US5089043A (en) * | 1989-11-09 | 1992-02-18 | Shionogi & Co., Ltd. | Heterocyclic oxy-phenoxyacetic acid derivatives and their use as herbicides |
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JP2869854B2 (ja) | 1994-10-19 | 1999-03-10 | 株式会社トスカ | 合成樹脂の成形方法とその装置 |
JP3534903B2 (ja) * | 1995-06-09 | 2004-06-07 | 鐘淵化学工業株式会社 | 1−[3−クロロ−(2s)−メチルプロピオニル]−ピロリジン−(2s)−カルボン酸の製造方法 |
GB9603699D0 (en) | 1996-02-21 | 1996-04-17 | Boots Co Plc | Therapeutic composition |
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