EA201690480A1 - Производные пирролидина в качестве антагонистов рецепторов окситоцина/вазопрессина v1a - Google Patents

Производные пирролидина в качестве антагонистов рецепторов окситоцина/вазопрессина v1a

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Publication number
EA201690480A1
EA201690480A1 EA201690480A EA201690480A EA201690480A1 EA 201690480 A1 EA201690480 A1 EA 201690480A1 EA 201690480 A EA201690480 A EA 201690480A EA 201690480 A EA201690480 A EA 201690480A EA 201690480 A1 EA201690480 A1 EA 201690480A1
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EA
Eurasian Patent Office
Prior art keywords
oxytocin
vazopressin
antagonists
receptors
pyrrolidin derivatives
Prior art date
Application number
EA201690480A
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English (en)
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EA036830B1 (ru
Inventor
Андрэ Шолле
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Обсева С.А.
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Publication date
Application filed by Обсева С.А. filed Critical Обсева С.А.
Publication of EA201690480A1 publication Critical patent/EA201690480A1/ru
Publication of EA036830B1 publication Critical patent/EA036830B1/ru

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Настоящее изобретение относится к соединению формулы О-метилоксим (3Z,5S)-5-(гидроксиметил)-1-[(2'-метил-1,1'-бифенил-4-ил)карбонил]пирролидин-3-она и/или активному метаболиту указанного соединения, обладающему антагонистическим действием на рецептор окситоцина и/или рецептор вазопрессина V1a, к способам их получения, фармацевтическим композициям, содержащим указанные соединения, и их применению.
EA201690480A 2013-09-10 2014-07-25 ПРИМЕНЕНИЕ ПРОИЗВОДНЫХ ПИРРОЛИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ ОКСИТОЦИНА/ВАЗОПРЕССИНА V1a ДЛЯ УЛУЧШЕНИЯ РЕЗУЛЬТАТОВ ПЕРЕНОСА ЭМБРИОНА У ПАЦИЕНТОВ, КОТОРЫЕ ПОДВЕРГАЮТСЯ ПРОЦЕДУРЕ ВСПОМОГАТЕЛЬНОЙ РЕПРОДУКТИВНОЙ ТЕХНОЛОГИИ EA036830B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13183723.9A EP2845850A1 (en) 2013-09-10 2013-09-10 Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
PCT/EP2014/066075 WO2015036160A1 (en) 2013-09-10 2014-07-25 PYRROLIDINE DERIVATIVES AS OXYTOCIN / VASOPRESSIN V1a RECEPTORS ANTAGONISTS

Publications (2)

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EA201690480A1 true EA201690480A1 (ru) 2016-08-31
EA036830B1 EA036830B1 (ru) 2020-12-24

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Family Applications (2)

Application Number Title Priority Date Filing Date
EA202092300A EA202092300A1 (ru) 2013-09-10 2014-07-25 ПРОИЗВОДНЫЕ ПИРРОЛИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ ОКСИТОЦИНА/ВАЗОПРЕССИНА V1a
EA201690480A EA036830B1 (ru) 2013-09-10 2014-07-25 ПРИМЕНЕНИЕ ПРОИЗВОДНЫХ ПИРРОЛИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ ОКСИТОЦИНА/ВАЗОПРЕССИНА V1a ДЛЯ УЛУЧШЕНИЯ РЕЗУЛЬТАТОВ ПЕРЕНОСА ЭМБРИОНА У ПАЦИЕНТОВ, КОТОРЫЕ ПОДВЕРГАЮТСЯ ПРОЦЕДУРЕ ВСПОМОГАТЕЛЬНОЙ РЕПРОДУКТИВНОЙ ТЕХНОЛОГИИ

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EA202092300A EA202092300A1 (ru) 2013-09-10 2014-07-25 ПРОИЗВОДНЫЕ ПИРРОЛИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ РЕЦЕПТОРОВ ОКСИТОЦИНА/ВАЗОПРЕССИНА V1a

Country Status (23)

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US (6) US20160221944A1 (ru)
EP (4) EP2845850A1 (ru)
JP (6) JP2016529258A (ru)
KR (3) KR101907338B1 (ru)
CN (4) CN107674011A (ru)
AU (3) AU2014320694B2 (ru)
BR (1) BR112016005276B1 (ru)
CA (2) CA2921580C (ru)
CY (1) CY1120152T1 (ru)
DK (1) DK3044206T3 (ru)
EA (2) EA202092300A1 (ru)
ES (2) ES2914776T3 (ru)
HK (2) HK1221716A1 (ru)
HU (1) HUE037578T2 (ru)
IL (2) IL244152A (ru)
MX (1) MX370602B (ru)
PT (1) PT3044206T (ru)
SG (2) SG11201601743RA (ru)
SI (1) SI3044206T1 (ru)
TR (1) TR201807175T4 (ru)
UA (1) UA115708C2 (ru)
WO (1) WO2015036160A1 (ru)
ZA (1) ZA201704072B (ru)

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EP2845850A1 (en) 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
EP2886107A1 (en) 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
EA201891873A1 (ru) * 2014-07-02 2019-04-30 Обсева Са Кристаллический о-метилоксим (3z,5s)-5-(гидроксиметил)-1-[(2'-метил-1,1'-бифенил-4-ил)карбонил]пирролидин-3-он, полезный в способах лечения состояний, связанных с активностью ot-r
SG11201804594YA (en) 2016-01-04 2018-06-28 Merck Serono Sa L-valinate of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
MX2018012351A (es) * 2016-04-12 2019-02-07 Trigemina Inc Formulaciones de oxitocina que contienen magnesio y metodos de uso.
ES2898778T3 (es) * 2016-07-21 2022-03-08 ObsEva SA Pautas posológicas de antagonistas de oxitocina para promover la implantación de embriones y prevenir aborto espontáneo
AU2020340670A1 (en) 2019-09-03 2022-04-07 ObsEva S.A. Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage
CN115380122A (zh) 2020-02-10 2022-11-22 奥布赛瓦股份公司 用于催产素受体拮抗剂疗法的生物标志物
RU2756027C1 (ru) * 2021-02-24 2021-09-24 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта" Способ диагностики наружного генитального эндометриоза
WO2024073451A1 (en) * 2022-09-30 2024-04-04 Ocelot Bio, Inc. Mixed vasopressin receptor agonist-antagonist for treating end-stage liver disease and complications associated thereof

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