EA202092008A1 - Противораковые фармацевтические композиции для комплексной терапии - Google Patents

Противораковые фармацевтические композиции для комплексной терапии

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Publication number
EA202092008A1
EA202092008A1 EA202092008A EA202092008A EA202092008A1 EA 202092008 A1 EA202092008 A1 EA 202092008A1 EA 202092008 A EA202092008 A EA 202092008A EA 202092008 A EA202092008 A EA 202092008A EA 202092008 A1 EA202092008 A1 EA 202092008A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical compositions
complex therapy
cancer pharmaceutical
combined use
relates
Prior art date
Application number
EA202092008A
Other languages
English (en)
Inventor
Джузеппе Мерлино
Марио Бигиони
Моника Бинисчи
Андреа Пеллакани
Original Assignee
Берлин-Хеми Аг
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Application filed by Берлин-Хеми Аг filed Critical Берлин-Хеми Аг
Publication of EA202092008A1 publication Critical patent/EA202092008A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Настоящее изобретение относится к новым комбинациям противоопухолевых или противораковых средств для комплексной терапии опухолей, к фармацевтическим композициям, предназначенным для комбинированного применения, и к набору, содержащему композиции с различными противоопухолевыми средствами для комбинированного применения. В частности, настоящее изобретение относится к комбинациям различных противоопухолевых средств с ингибитором PI3K класса I 5-(7-метансульфонил-2-морфолин-4-ил-6,7-дигидро-5H-пирроло[2,3-d]пиримидин-4-ил)пиримидин-2-ил-амином или его фармацевтически приемлемыми солями.
EA202092008A 2018-03-29 2019-03-28 Противораковые фармацевтические композиции для комплексной терапии EA202092008A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102018000004082A IT201800004082A1 (it) 2018-03-29 2018-03-29 Composizioni farmaceutiche antitumorali per terapia combinata
PCT/IB2019/052541 WO2019186451A1 (en) 2018-03-29 2019-03-28 Anticancer pharmaceutical compositions for combined therapy

Publications (1)

Publication Number Publication Date
EA202092008A1 true EA202092008A1 (ru) 2021-01-18

Family

ID=62875088

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202092008A EA202092008A1 (ru) 2018-03-29 2019-03-28 Противораковые фармацевтические композиции для комплексной терапии

Country Status (28)

Country Link
US (1) US20210015826A1 (ru)
EP (1) EP3773595B1 (ru)
JP (1) JP7460596B2 (ru)
KR (1) KR20200138294A (ru)
CN (1) CN111918656B (ru)
AU (1) AU2019244793A1 (ru)
BR (1) BR112020019712A2 (ru)
CL (1) CL2020002424A1 (ru)
DK (1) DK3773595T3 (ru)
EA (1) EA202092008A1 (ru)
ES (1) ES2954502T3 (ru)
FI (1) FI3773595T3 (ru)
HR (1) HRP20231131T1 (ru)
HU (1) HUE063047T2 (ru)
IL (1) IL277649A (ru)
IT (1) IT201800004082A1 (ru)
LT (1) LT3773595T (ru)
MX (1) MX2020010084A (ru)
PH (1) PH12020551583A1 (ru)
PL (1) PL3773595T3 (ru)
PT (1) PT3773595T (ru)
RS (1) RS64639B1 (ru)
RU (1) RU2020131376A (ru)
SG (1) SG11202009483YA (ru)
SI (1) SI3773595T1 (ru)
TW (1) TWI816768B (ru)
UA (1) UA127288C2 (ru)
WO (1) WO2019186451A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113368114B (zh) * 2020-03-10 2022-04-22 四川大学 一种吗啉嘧啶类化合物的抗肿瘤应用
WO2024023766A1 (en) * 2022-07-28 2024-02-01 Berlin-Chemie Ag P13k inhibitor combination therapy

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7932026B2 (en) * 2004-06-04 2011-04-26 Genentech, Inc. EGFR mutations
TW200938201A (en) * 2008-02-07 2009-09-16 Chugai Pharmaceutical Co Ltd Pyrrolopyrimidine derivative as PI3K inhibitor and use thereof
EA201300341A1 (ru) * 2010-09-16 2013-09-30 Шимода Байотек (Пти) Лтд. Композиция фулвестранта и способы применения
WO2012118978A1 (en) * 2011-03-03 2012-09-07 The Regents Of The University Of Colorado, A Body Corporate Methods for treating oncovirus positive cancers
US20130123255A1 (en) * 2011-11-10 2013-05-16 Chugai Seiyaku Kabushiki Kaisha Combination of a pi3k inhibitor and a mek inhibitor
US20150352076A1 (en) * 2013-01-25 2015-12-10 Toshiyuku SAKAI Molecularly targeted combination drug for tumor treatment and prevention
EP2968294B1 (en) * 2013-03-13 2019-05-01 Oncoceutics, Inc. 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-on for use in the treatment of cancer
WO2014203129A1 (en) * 2013-06-19 2014-12-24 Olema Pharmaceuticals, Inc. Combinations of benzopyran compounds, compositions and uses thereof
WO2015069217A1 (en) * 2013-11-05 2015-05-14 Baylor College Of Medicine Src kinase inhibition as treatment for lympangioleiomyomatosis and tuberous sclerosis
WO2015095807A1 (en) * 2013-12-20 2015-06-25 Biomed Valley Discoveries, Inc. Cancer treatments using combinations of egfr and erk inhibitors
FR3033499A1 (fr) * 2015-03-11 2016-09-16 Centre Leon-Berard Composition pour le traitement des tumeurs neuroendocrines pancreatiques
WO2016193955A1 (en) * 2015-06-04 2016-12-08 Giorgio Stassi Combinations of kinase inhibitors for treating colorectal cancer

Also Published As

Publication number Publication date
WO2019186451A1 (en) 2019-10-03
RS64639B1 (sr) 2023-10-31
HRP20231131T1 (hr) 2024-01-05
HUE063047T2 (hu) 2023-12-28
EP3773595A1 (en) 2021-02-17
US20210015826A1 (en) 2021-01-21
CN111918656A (zh) 2020-11-10
KR20200138294A (ko) 2020-12-09
SG11202009483YA (en) 2020-10-29
EP3773595B1 (en) 2023-07-12
JP2021519821A (ja) 2021-08-12
TW202002984A (zh) 2020-01-16
PL3773595T3 (pl) 2023-11-27
PT3773595T (pt) 2023-09-07
PH12020551583A1 (en) 2021-09-13
DK3773595T3 (da) 2023-09-18
SI3773595T1 (sl) 2023-11-30
BR112020019712A2 (pt) 2021-02-09
FI3773595T3 (fi) 2023-09-01
JP7460596B2 (ja) 2024-04-02
LT3773595T (lt) 2023-09-25
CN111918656B (zh) 2023-08-08
IL277649A (en) 2020-11-30
UA127288C2 (uk) 2023-07-12
TWI816768B (zh) 2023-10-01
ES2954502T3 (es) 2023-11-22
AU2019244793A1 (en) 2020-10-08
RU2020131376A (ru) 2022-04-29
IT201800004082A1 (it) 2019-09-29
MX2020010084A (es) 2021-01-15
CL2020002424A1 (es) 2021-03-12

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