EA202091982A1 - Химерный антигенный рецептор к рецептору il-13 альфа 2 (il13r2) для опухолеспецифической т-клеточной иммунотерапии - Google Patents

Химерный антигенный рецептор к рецептору il-13 альфа 2 (il13r2) для опухолеспецифической т-клеточной иммунотерапии

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Publication number
EA202091982A1
EA202091982A1 EA202091982A EA202091982A EA202091982A1 EA 202091982 A1 EA202091982 A1 EA 202091982A1 EA 202091982 A EA202091982 A EA 202091982A EA 202091982 A EA202091982 A EA 202091982A EA 202091982 A1 EA202091982 A1 EA 202091982A1
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EA
Eurasian Patent Office
Prior art keywords
receptor
il13r2
alpha
tumor
specific
Prior art date
Application number
EA202091982A
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English (en)
Russian (ru)
Inventor
Джакомо Тампелла
Майкл К. Дженсен
Original Assignee
Сиэтл Чилдрен'С Хоспитал (Дба Сиэтл Чилдрен'С Ресёрч Инститьют)
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Publication of EA202091982A1 publication Critical patent/EA202091982A1/ru

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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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EA202091982A 2018-03-14 2019-03-12 Химерный антигенный рецептор к рецептору il-13 альфа 2 (il13r2) для опухолеспецифической т-клеточной иммунотерапии EA202091982A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862643055P 2018-03-14 2018-03-14
PCT/US2019/021823 WO2019178078A1 (en) 2018-03-14 2019-03-12 Il-13 receptor alpha 2 (il13ra2) chimeric antigen receptor for tumor specific t cell immunotherapy

Publications (1)

Publication Number Publication Date
EA202091982A1 true EA202091982A1 (ru) 2021-06-10

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EA202091982A EA202091982A1 (ru) 2018-03-14 2019-03-12 Химерный антигенный рецептор к рецептору il-13 альфа 2 (il13r2) для опухолеспецифической т-клеточной иммунотерапии

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US (2) US12152079B2 (https=)
EP (1) EP3765041A4 (https=)
JP (2) JP7438123B2 (https=)
KR (1) KR102805003B1 (https=)
CN (1) CN112236151A (https=)
AU (1) AU2019234573B2 (https=)
BR (1) BR112020018670A2 (https=)
CA (1) CA3093810A1 (https=)
EA (1) EA202091982A1 (https=)
IL (2) IL277267B2 (https=)
MX (1) MX2020009463A (https=)
SG (1) SG11202008795SA (https=)
WO (1) WO2019178078A1 (https=)

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CN115246883B (zh) * 2021-02-02 2025-04-11 浙江理工大学 一种抗人源IL13Ra2鲨鱼单域抗体或其抗原结合片段和应用
AU2022227686A1 (en) 2021-02-25 2023-07-27 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
JP2024514101A (ja) * 2021-04-01 2024-03-28 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ Ｉｌ－１３ｒａ２キメラ抗原受容体および使用方法
JP2024527539A (ja) * 2021-07-01 2024-07-25 寧波茂行生物医薬科技有限公司 ＩＬ１３Ｒα２を標的としたユニバーサルＣＡＲ－Ｔ細胞及びその製造方法と使用
CN116589585B (zh) * 2021-12-29 2023-11-24 华道(上海)生物医药有限公司 一种抗IL13Ra2的纳米抗体及其应用
CN114014941B (zh) * 2022-01-10 2022-04-12 卡瑞济(北京)生命科技有限公司 靶向IL13Rα2的嵌合抗原受体及其用途
WO2023138666A1 (en) * 2022-01-19 2023-07-27 Utc Therapeutics (Shanghai) Co., Ltd. Circular rna and use thereof
CN114990069B (zh) * 2022-05-17 2023-09-22 郑州大学第一附属医院 一种过表达slc43a2的嵌合抗原受体t细胞的制备方法和应用
CN114805581B (zh) * 2022-06-29 2022-10-14 上海优替济生生物医药有限公司 靶向il13ra2的抗体、嵌合抗原受体及其用途
CN119654345A (zh) * 2022-08-25 2025-03-18 南京传奇生物科技有限公司 靶向白介素13受体亚基α2的嵌合抗原受体及其使用方法
CN115960257B (zh) * 2022-09-29 2023-10-27 卡瑞济(北京)生命科技有限公司 靶向IL13Rα2的经优化的嵌合抗原受体及其用途
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
WO2025154925A1 (ko) * 2024-01-18 2025-07-24 엑셀라몰(주) IL13Ra2에 결합하는 폴리펩타이드 약물 접합체 및 이의 용도

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