EA202091984A1 - Направленная дзетакинами т-клеточная иммунотерапия, нацеленная на рецептор il-13 альфа 2 - Google Patents

Направленная дзетакинами т-клеточная иммунотерапия, нацеленная на рецептор il-13 альфа 2

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Publication number
EA202091984A1
EA202091984A1 EA202091984A EA202091984A EA202091984A1 EA 202091984 A1 EA202091984 A1 EA 202091984A1 EA 202091984 A EA202091984 A EA 202091984A EA 202091984 A EA202091984 A EA 202091984A EA 202091984 A1 EA202091984 A1 EA 202091984A1
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EA
Eurasian Patent Office
Prior art keywords
receptor
alpha
directed
receptors
zetakin
Prior art date
Application number
EA202091984A
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English (en)
Inventor
Джакомо Тампелла
Майкл К. Дженсен
Адам Джонсон
Original Assignee
Сиэтл Чилдрен'С Хоспитал (Дба Сиэтл Чилдрен'С Ресёрч Инститьют)
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Publication of EA202091984A1 publication Critical patent/EA202091984A1/ru

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Abstract

Некоторые варианты осуществления способов и композиций, предложенных в настоящем документе, включают клетки, имеющие прикрепленные к мембране направленные мутеином IL-13 дзетакиновые рецепторы, такие как рецепторы, которые специфически связываются с рецептором IL-13 альфа 2 (IL13Ra2) с аффинностью, в 50 раз превышающей аффинность IL-13 дикого типа, и способы клеточной иммунотерапии, нацеленной на раковые клетки, такие как клетки солидных опухолей, с применением этих композиций. В некоторых вариантах осуществления рецепторы включают спейсерные области, такие как определенные спейсерные области, предназначенные для обеспечения определенных преимуществ.
EA202091984A 2018-03-14 2019-03-12 Направленная дзетакинами т-клеточная иммунотерапия, нацеленная на рецептор il-13 альфа 2 EA202091984A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862643139P 2018-03-14 2018-03-14
PCT/US2019/021833 WO2019178085A1 (en) 2018-03-14 2019-03-12 Il-13 receptor alpha 2 targeted, zetakine directed t cell immunotherapy

Publications (1)

Publication Number Publication Date
EA202091984A1 true EA202091984A1 (ru) 2021-02-18

Family

ID=67907266

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Application Number Title Priority Date Filing Date
EA202091984A EA202091984A1 (ru) 2018-03-14 2019-03-12 Направленная дзетакинами т-клеточная иммунотерапия, нацеленная на рецептор il-13 альфа 2

Country Status (13)

Country Link
US (1) US20210017246A1 (ru)
EP (1) EP3765487A4 (ru)
JP (2) JP7314161B2 (ru)
KR (1) KR20200131851A (ru)
CN (1) CN112088165A (ru)
AU (2) AU2019234580B2 (ru)
BR (1) BR112020018534A2 (ru)
CA (1) CA3093791A1 (ru)
EA (1) EA202091984A1 (ru)
IL (1) IL277268A (ru)
MX (1) MX2020009464A (ru)
SG (1) SG11202008926RA (ru)
WO (1) WO2019178085A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024041650A1 (en) * 2022-08-25 2024-02-29 Nanjing Legend Biotech Co., Ltd. Chimeric antigen receptors targeting interleukin 13 receptor subunit alpha 2 and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090257994A1 (en) * 2001-04-30 2009-10-15 City Of Hope Chimeric immunoreceptor useful in treating human cancers
US20090098142A1 (en) * 2004-06-09 2009-04-16 Kasaian Marion T Methods and compositions for treating and monitoring treatment of IL-13-associated disorders
ES2961498T3 (es) * 2008-08-26 2024-03-12 Hope City Método y composiciones para el funcionamiento mejorado del efecto antitumoral de las células T
JP5956342B2 (ja) 2009-11-03 2016-07-27 シティ・オブ・ホープＣｉｔｙ ｏｆ Ｈｏｐｅ 形質導入Ｔ細胞選択のためのトランケート上皮増殖因子レセプタ（ＥＧＦＲｔ）
DK2997134T3 (da) 2013-05-14 2020-09-28 Univ Texas Human anvendelse af genmanipulerede kimære antigenreceptor-(car)-t-celler
WO2016044811A1 (en) 2014-09-19 2016-03-24 City Of Hope COSTIMULATORY CHIMERIC ANTIGEN RECEPTOR T CELLS TARGETING IL13Rα2
JP6905163B2 (ja) * 2015-09-03 2021-07-21 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア サイトカイン放出症候群を予測するバイオマーカー
CA3013773A1 (en) * 2016-02-05 2017-08-10 City Of Hope Administration of engineered t cells for treatment of cancers in the central nervous system
AU2017301880C1 (en) * 2016-07-29 2022-04-21 Juno Therapeutics, Inc. Immunomodulatory polypeptides and related compositions and methods
AU2017319702A1 (en) 2016-09-02 2019-04-11 The Regents Of The University Of California Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments

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Publication number Publication date
SG11202008926RA (en) 2020-10-29
EP3765487A4 (en) 2022-01-05
JP2021518111A (ja) 2021-08-02
EP3765487A1 (en) 2021-01-20
IL277268A (en) 2020-10-29
US20210017246A1 (en) 2021-01-21
CA3093791A1 (en) 2019-09-19
MX2020009464A (es) 2021-01-15
AU2019234580B2 (en) 2024-02-01
CN112088165A (zh) 2020-12-15
JP2023134631A (ja) 2023-09-27
AU2019234580A1 (en) 2020-10-08
WO2019178085A1 (en) 2019-09-19
AU2024202681A1 (en) 2024-05-16
JP7314161B2 (ja) 2023-07-25
BR112020018534A2 (pt) 2020-12-29
KR20200131851A (ko) 2020-11-24

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