MX2020009464A - Inmunoterapia de células t dirigidas por zetacina, direccionada al receptor alfa 2 de il-13. - Google Patents

Inmunoterapia de células t dirigidas por zetacina, direccionada al receptor alfa 2 de il-13.

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Publication number
MX2020009464A
MX2020009464A MX2020009464A MX2020009464A MX2020009464A MX 2020009464 A MX2020009464 A MX 2020009464A MX 2020009464 A MX2020009464 A MX 2020009464A MX 2020009464 A MX2020009464 A MX 2020009464A MX 2020009464 A MX2020009464 A MX 2020009464A
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MX
Mexico
Prior art keywords
zetakine
directed
receptor alpha
targeted
cell immunotherapy
Prior art date
Application number
MX2020009464A
Other languages
English (en)
Inventor
Michael C Jensen
Adam Johnson
Giacomo Tampella
Original Assignee
Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seattle Childrens Hospital Dba Seattle Childrens Res Inst filed Critical Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Publication of MX2020009464A publication Critical patent/MX2020009464A/es

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    • A61K35/14—Blood; Artificial blood
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    • A—HUMAN NECESSITIES
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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Abstract

Algunas modalidades de los métodos y composiciones proporcionados en la presente incluyen células que tienen receptores de zetacina dirigidos a muteína de IL13 unidos a la membrana, tal como aquellos que se unen específicamente al receptor alfa 2 de IL-13 (IL13Ra2) a una afinidad 50 veces mayor que IL-13 tipo silvestre, y métodos de inmunoterapia basada en células dirigidos o direccionados a células de cáncer, tal como células de tumores sólidos, usando estas composiciones. En algunas modalidades, los receptores incluyen regiones separadoras, tal como regiones separadoras particulares diseñadas para proporcionar ciertas ventajas.
MX2020009464A 2018-03-14 2019-03-12 Inmunoterapia de células t dirigidas por zetacina, direccionada al receptor alfa 2 de il-13. MX2020009464A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862643139P 2018-03-14 2018-03-14
PCT/US2019/021833 WO2019178085A1 (en) 2018-03-14 2019-03-12 Il-13 receptor alpha 2 targeted, zetakine directed t cell immunotherapy

Publications (1)

Publication Number Publication Date
MX2020009464A true MX2020009464A (es) 2021-01-15

Family

ID=67907266

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020009464A MX2020009464A (es) 2018-03-14 2019-03-12 Inmunoterapia de células t dirigidas por zetacina, direccionada al receptor alfa 2 de il-13.

Country Status (13)

Country Link
US (1) US20210017246A1 (es)
EP (1) EP3765487A4 (es)
JP (2) JP7314161B2 (es)
KR (1) KR20200131851A (es)
CN (1) CN112088165A (es)
AU (2) AU2019234580B2 (es)
BR (1) BR112020018534A2 (es)
CA (1) CA3093791A1 (es)
EA (1) EA202091984A1 (es)
IL (1) IL277268A (es)
MX (1) MX2020009464A (es)
SG (1) SG11202008926RA (es)
WO (1) WO2019178085A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024041650A1 (en) * 2022-08-25 2024-02-29 Nanjing Legend Biotech Co., Ltd. Chimeric antigen receptors targeting interleukin 13 receptor subunit alpha 2 and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090257994A1 (en) * 2001-04-30 2009-10-15 City Of Hope Chimeric immunoreceptor useful in treating human cancers
US20090098142A1 (en) * 2004-06-09 2009-04-16 Kasaian Marion T Methods and compositions for treating and monitoring treatment of IL-13-associated disorders
PT3006459T (pt) * 2008-08-26 2021-11-26 Hope City Método e composições para funcionamento melhorado de efetores antitumorais de células t
SI2496698T1 (sl) 2009-11-03 2019-07-31 City Of Hope Skrajšan epiderimalni receptor faktorja rasti (EGFRt) za selekcijo transduciranih T celic
CN105408473B9 (zh) 2013-05-14 2021-09-17 得克萨斯州大学系统董事会 工程化嵌合抗原受体(car)t细胞的人应用
IL308324A (en) * 2014-09-19 2024-01-01 Hope City IL13RA2-targeted chimeric antigen receptor T cells
US11747346B2 (en) * 2015-09-03 2023-09-05 Novartis Ag Biomarkers predictive of cytokine release syndrome
KR20180105709A (ko) * 2016-02-05 2018-09-28 시티 오브 호프 중추 신경계의 암의 치료를 위한 조작된 t 세포의 투여
MX2019001185A (es) * 2016-07-29 2019-10-21 Juno Therapeutics Inc Polipeptidos inmunomoduladores y composiciones y metodos relacionados.
CN109963590B (zh) 2016-09-02 2024-03-15 加利福尼亚大学董事会 涉及白介素-6受体α结合单链可变片段的方法和组合物

Also Published As

Publication number Publication date
AU2019234580A1 (en) 2020-10-08
BR112020018534A2 (pt) 2020-12-29
JP7314161B2 (ja) 2023-07-25
AU2019234580B2 (en) 2024-02-01
EP3765487A1 (en) 2021-01-20
CN112088165A (zh) 2020-12-15
EA202091984A1 (ru) 2021-02-18
US20210017246A1 (en) 2021-01-21
EP3765487A4 (en) 2022-01-05
JP2023134631A (ja) 2023-09-27
JP2021518111A (ja) 2021-08-02
CA3093791A1 (en) 2019-09-19
KR20200131851A (ko) 2020-11-24
SG11202008926RA (en) 2020-10-29
AU2024202681A1 (en) 2024-05-16
WO2019178085A1 (en) 2019-09-19
IL277268A (en) 2020-10-29

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