AU2019234573B2 - IL-13 receptor alpha 2 (IL13Ra2) chimeric antigen receptor for tumor specific T cell immunotherapy - Google Patents

IL-13 receptor alpha 2 (IL13Ra2) chimeric antigen receptor for tumor specific T cell immunotherapy

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Publication number
AU2019234573B2
AU2019234573B2 AU2019234573A AU2019234573A AU2019234573B2 AU 2019234573 B2 AU2019234573 B2 AU 2019234573B2 AU 2019234573 A AU2019234573 A AU 2019234573A AU 2019234573 A AU2019234573 A AU 2019234573A AU 2019234573 B2 AU2019234573 B2 AU 2019234573B2
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AU2019234573A1 (en
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Michael C. Jensen
Giacomo TAMPELLA
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Seattle Childrens Hospital
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Seattle Childrens Hospital
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N15/09—Recombinant DNA-technology
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0634—Cells from the blood or the immune system
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    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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AU2019234573A 2018-03-14 2019-03-12 IL-13 receptor alpha 2 (IL13Ra2) chimeric antigen receptor for tumor specific T cell immunotherapy Active AU2019234573B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862643055P 2018-03-14 2018-03-14
US62/643,055 2018-03-14
PCT/US2019/021823 WO2019178078A1 (en) 2018-03-14 2019-03-12 Il-13 receptor alpha 2 (il13ra2) chimeric antigen receptor for tumor specific t cell immunotherapy

Publications (2)

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AU2019234573A1 AU2019234573A1 (en) 2020-10-08
AU2019234573B2 true AU2019234573B2 (en) 2026-01-22

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AU2019234573A Active AU2019234573B2 (en) 2018-03-14 2019-03-12 IL-13 receptor alpha 2 (IL13Ra2) chimeric antigen receptor for tumor specific T cell immunotherapy

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US (2) US12152079B2 (https=)
EP (1) EP3765041A4 (https=)
JP (2) JP7438123B2 (https=)
KR (1) KR102805003B1 (https=)
CN (1) CN112236151A (https=)
AU (1) AU2019234573B2 (https=)
BR (1) BR112020018670A2 (https=)
CA (1) CA3093810A1 (https=)
EA (1) EA202091982A1 (https=)
IL (2) IL277267B2 (https=)
MX (1) MX2020009463A (https=)
SG (1) SG11202008795SA (https=)
WO (1) WO2019178078A1 (https=)

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EP3842461A1 (en) * 2019-12-23 2021-06-30 Albert-Ludwigs-Universität Freiburg Chimeric antigen receptors that bind to prostate specific membrane antigen
KR20230022411A (ko) * 2020-05-12 2023-02-15 라이엘 이뮤노파마, 인크. 키메라 항원 수용체 스페이서
CN115246883B (zh) * 2021-02-02 2025-04-11 浙江理工大学 一种抗人源IL13Ra2鲨鱼单域抗体或其抗原结合片段和应用
AU2022227686A1 (en) 2021-02-25 2023-07-27 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
JP2024514101A (ja) * 2021-04-01 2024-03-28 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ Ｉｌ－１３ｒａ２キメラ抗原受容体および使用方法
JP2024527539A (ja) * 2021-07-01 2024-07-25 寧波茂行生物医薬科技有限公司 ＩＬ１３Ｒα２を標的としたユニバーサルＣＡＲ－Ｔ細胞及びその製造方法と使用
CN116589585B (zh) * 2021-12-29 2023-11-24 华道(上海)生物医药有限公司 一种抗IL13Ra2的纳米抗体及其应用
CN114014941B (zh) * 2022-01-10 2022-04-12 卡瑞济(北京)生命科技有限公司 靶向IL13Rα2的嵌合抗原受体及其用途
WO2023138666A1 (en) * 2022-01-19 2023-07-27 Utc Therapeutics (Shanghai) Co., Ltd. Circular rna and use thereof
CN114990069B (zh) * 2022-05-17 2023-09-22 郑州大学第一附属医院 一种过表达slc43a2的嵌合抗原受体t细胞的制备方法和应用
CN114805581B (zh) * 2022-06-29 2022-10-14 上海优替济生生物医药有限公司 靶向il13ra2的抗体、嵌合抗原受体及其用途
CN119654345A (zh) * 2022-08-25 2025-03-18 南京传奇生物科技有限公司 靶向白介素13受体亚基α2的嵌合抗原受体及其使用方法
CN115960257B (zh) * 2022-09-29 2023-10-27 卡瑞济(北京)生命科技有限公司 靶向IL13Rα2的经优化的嵌合抗原受体及其用途
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
WO2025154925A1 (ko) * 2024-01-18 2025-07-24 엑셀라몰(주) IL13Ra2에 결합하는 폴리펩타이드 약물 접합체 및 이의 용도

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WO2017015490A1 (en) * 2015-07-21 2017-01-26 City Of Hope T cells for expression of chimeric antigen receptors and other receptors
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