EA202091691A1 - ТВЕРДЫЕ ФОРМЫ ЗАМЕЩЕННЫХ 5,6-ДИГИДРО-6-ФЕНИЛБЕНЗО[f]ИЗОХИНОЛИН-2-АМИНОВЫХ СОЕДИНЕНИЙ - Google Patents

ТВЕРДЫЕ ФОРМЫ ЗАМЕЩЕННЫХ 5,6-ДИГИДРО-6-ФЕНИЛБЕНЗО[f]ИЗОХИНОЛИН-2-АМИНОВЫХ СОЕДИНЕНИЙ

Info

Publication number
EA202091691A1
EA202091691A1 EA202091691A EA202091691A EA202091691A1 EA 202091691 A1 EA202091691 A1 EA 202091691A1 EA 202091691 A EA202091691 A EA 202091691A EA 202091691 A EA202091691 A EA 202091691A EA 202091691 A1 EA202091691 A1 EA 202091691A1
Authority
EA
Eurasian Patent Office
Prior art keywords
solid forms
isochinoline
phenylbenzo
dihydro
substituted
Prior art date
Application number
EA202091691A
Other languages
English (en)
Russian (ru)
Inventor
Крейг Бэйтс
Дэвид П. Рид
Original Assignee
Аркьюл, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аркьюл, Инк. filed Critical Аркьюл, Инк.
Publication of EA202091691A1 publication Critical patent/EA202091691A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA202091691A 2015-12-17 2016-12-16 ТВЕРДЫЕ ФОРМЫ ЗАМЕЩЕННЫХ 5,6-ДИГИДРО-6-ФЕНИЛБЕНЗО[f]ИЗОХИНОЛИН-2-АМИНОВЫХ СОЕДИНЕНИЙ EA202091691A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562268747P 2015-12-17 2015-12-17

Publications (1)

Publication Number Publication Date
EA202091691A1 true EA202091691A1 (ru) 2021-01-29

Family

ID=59057612

Family Applications (2)

Application Number Title Priority Date Filing Date
EA202091691A EA202091691A1 (ru) 2015-12-17 2016-12-16 ТВЕРДЫЕ ФОРМЫ ЗАМЕЩЕННЫХ 5,6-ДИГИДРО-6-ФЕНИЛБЕНЗО[f]ИЗОХИНОЛИН-2-АМИНОВЫХ СОЕДИНЕНИЙ
EA201891430A EA036295B1 (ru) 2015-12-17 2016-12-16 Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201891430A EA036295B1 (ru) 2015-12-17 2016-12-16 Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений

Country Status (19)

Country Link
US (3) US9981921B2 (https=)
EP (2) EP4019499A1 (https=)
JP (2) JP2018537499A (https=)
KR (1) KR20180086508A (https=)
CN (1) CN108368061A (https=)
AU (2) AU2016369523B2 (https=)
BR (1) BR112018012095A2 (https=)
CA (1) CA3006081A1 (https=)
EA (2) EA202091691A1 (https=)
ES (1) ES2935818T3 (https=)
HK (1) HK1256825A1 (https=)
IL (1) IL259556B2 (https=)
MX (2) MX394320B (https=)
NZ (1) NZ742695A (https=)
PH (2) PH12018501246A1 (https=)
SA (1) SA518391805B1 (https=)
SG (1) SG11201804670PA (https=)
TW (2) TWI796250B (https=)
WO (1) WO2017106642A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3006077A1 (en) 2015-12-17 2017-06-22 Arqule, Inc. Methods for preparing polymorphs of substituted 5,6-dihydrobenzo[h]quinazolin-2-amine
IL259556B2 (en) * 2015-12-17 2023-09-01 Arqule Inc Solid forms of substituted 6,5-dihydro-6-phenyl-benzo[f]isoquinoline-2-amine compounds
WO2022053708A1 (en) 2020-09-14 2022-03-17 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma
JP7641247B2 (ja) 2022-03-02 2025-03-06 日立建機株式会社 機械の性能診断装置

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
EP0946523A1 (en) * 1996-12-23 1999-10-06 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
JP4037898B2 (ja) * 2003-06-18 2008-01-23 テバ ファーマシューティカル インダストリーズ リミティド フルバスタチンナトリウム結晶形ｘｉｖ、ｌｘｘｉｉｉ、ｌｘｘｉｘ、ｌｘｘｘ及びｘｘｘｖｉｉ型、それらの調製方法、それらを含有する組成物及びそれらの使用方法
JP2010514810A (ja) * 2006-12-29 2010-05-06 ライジェル ファーマシューティカルズ， インコーポレイテッド Ａｘｌインヒビターとして有用な置換トリアゾール
TWI461410B (zh) * 2008-12-30 2014-11-21 Arqule Inc 經取代之５，６－二氫－６－苯基苯並〔f〕異喹啉－２－胺化合物類
US9012464B2 (en) * 2010-11-25 2015-04-21 Ratiopharm Gmbh Salts and polymorphic forms of Afatinib
WO2012177852A1 (en) * 2011-06-24 2012-12-27 Arqule, Inc Substituted imidazopyridinyl compounds
US9802954B2 (en) * 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
EP2760859A1 (en) * 2011-09-30 2014-08-06 Sunshine Lake Pharma Co., Ltd Crystalline forms of azilsartan and preparation and uses thereof
IL259556B2 (en) * 2015-12-17 2023-09-01 Arqule Inc Solid forms of substituted 6,5-dihydro-6-phenyl-benzo[f]isoquinoline-2-amine compounds
CA3006077A1 (en) * 2015-12-17 2017-06-22 Arqule, Inc. Methods for preparing polymorphs of substituted 5,6-dihydrobenzo[h]quinazolin-2-amine
US9847831B2 (en) 2016-04-08 2017-12-19 Ciena Corporation Dual wavelenth optical time domain reflectometer systems and methods embedded in a WDM system

Also Published As

Publication number Publication date
IL259556A (en) 2018-07-31
SA518391805B1 (ar) 2022-12-21
CN108368061A (zh) 2018-08-03
US20170174636A1 (en) 2017-06-22
EP4019499A1 (en) 2022-06-29
EA036295B1 (ru) 2020-10-22
AU2022201947B2 (en) 2023-07-27
IL259556B1 (en) 2023-05-01
EP3390369B1 (en) 2022-11-02
US10227311B2 (en) 2019-03-12
US10717710B2 (en) 2020-07-21
MX2018007414A (es) 2018-11-09
MX394320B (es) 2025-03-24
ES2935818T3 (es) 2023-03-10
US20200002293A1 (en) 2020-01-02
AU2016369523A1 (en) 2018-06-07
MX385671B (es) 2025-03-18
US9981921B2 (en) 2018-05-29
TW201736352A (zh) 2017-10-16
WO2017106642A1 (en) 2017-06-22
JP2022031797A (ja) 2022-02-22
TWI796250B (zh) 2023-03-11
TW202241854A (zh) 2022-11-01
PH12018501246A1 (en) 2019-02-04
MX2021000432A (es) 2022-07-28
TWI771280B (zh) 2022-07-21
EA201891430A1 (ru) 2018-11-30
HK1256825A1 (zh) 2019-10-04
US20180258055A1 (en) 2018-09-13
AU2022201947A1 (en) 2022-04-14
CA3006081A1 (en) 2017-06-22
PH12020551465A1 (en) 2021-07-26
NZ742695A (en) 2022-10-28
IL259556B2 (en) 2023-09-01
SG11201804670PA (en) 2018-07-30
EP3390369A1 (en) 2018-10-24
BR112018012095A2 (pt) 2018-11-27
JP2018537499A (ja) 2018-12-20
EP3390369A4 (en) 2019-08-14
AU2016369523B2 (en) 2021-12-23
KR20180086508A (ko) 2018-07-31

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