HK1256825A1 - 取代的5，6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物的固体形式 - Google Patents

取代的5，6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物的固体形式 Download PDF

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Publication number
HK1256825A1
HK1256825A1 HK18115910.5A HK18115910A HK1256825A1 HK 1256825 A1 HK1256825 A1 HK 1256825A1 HK 18115910 A HK18115910 A HK 18115910A HK 1256825 A1 HK1256825 A1 HK 1256825A1
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HK
Hong Kong
Prior art keywords
powder diffraction
compound
ray powder
diffraction pattern
polymorph
Prior art date
Application number
HK18115910.5A
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English (en)
Chinese (zh)
Inventor
Craig Bates
David P. Reed
Original Assignee
Arqule, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule, Inc. filed Critical Arqule, Inc.
Publication of HK1256825A1 publication Critical patent/HK1256825A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK18115910.5A 2015-12-17 2016-12-16 取代的5，6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物的固体形式 HK1256825A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562268747P 2015-12-17 2015-12-17
US62/268747 2015-12-17
PCT/US2016/067164 WO2017106642A1 (en) 2015-12-17 2016-12-16 Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds

Publications (1)

Publication Number Publication Date
HK1256825A1 true HK1256825A1 (zh) 2019-10-04

Family

ID=59057612

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18115910.5A HK1256825A1 (zh) 2015-12-17 2016-12-16 取代的5，6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物的固体形式

Country Status (19)

Country Link
US (3) US9981921B2 (https=)
EP (2) EP3390369B1 (https=)
JP (2) JP2018537499A (https=)
KR (1) KR20180086508A (https=)
CN (1) CN108368061A (https=)
AU (2) AU2016369523B2 (https=)
BR (1) BR112018012095A2 (https=)
CA (1) CA3006081A1 (https=)
EA (2) EA036295B1 (https=)
ES (1) ES2935818T3 (https=)
HK (1) HK1256825A1 (https=)
IL (1) IL259556B2 (https=)
MX (2) MX394320B (https=)
NZ (1) NZ742695A (https=)
PH (2) PH12018501246A1 (https=)
SA (1) SA518391805B1 (https=)
SG (1) SG11201804670PA (https=)
TW (2) TWI796250B (https=)
WO (1) WO2017106642A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201804601TA (en) 2015-12-17 2018-07-30 Arqule Inc Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
EA036295B1 (ru) * 2015-12-17 2020-10-22 Аркьюл, Инк. Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений
WO2022053708A1 (en) 2020-09-14 2022-03-17 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma
JP7641247B2 (ja) 2022-03-02 2025-03-06 日立建機株式会社 機械の性能診断装置

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US6057329A (en) * 1996-12-23 2000-05-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
KR20070092994A (ko) * 2003-06-18 2007-09-14 테바 파마슈티컬 인더스트리즈 리미티드 플루바스타틴 나트륨 결정형 ｘｉｖ, ｌｘｘｉｉｉ,ｌｘｘｉｘ, ｌｘｘｘ 및 ｌｘｘｘｖｉｉ, 이의 제조 방법,이를 포함하는 조성물 및 이를 사용하는 방법
EP2079736B1 (en) * 2006-12-29 2017-10-18 Rigel Pharmaceuticals, Inc. Substituted triazoles useful as axl inhibitors
TWI461410B (zh) * 2008-12-30 2014-11-21 Arqule Inc 經取代之５，６－二氫－６－苯基苯並〔f〕異喹啉－２－胺化合物類
CN103476770B (zh) * 2010-11-25 2017-02-15 拉蒂欧制药有限责任公司 阿法替尼盐和多晶型物
US8815854B2 (en) * 2011-06-24 2014-08-26 Arqule, Inc. Substituted imidazopyridinyl compounds
US9802954B2 (en) * 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
JP2014530805A (ja) * 2011-09-30 2014-11-20 スンシネ ルアケ プハルマ カンパニー リミテッド アジルサルタンの結晶形並びにその製造及び使用
EA036295B1 (ru) * 2015-12-17 2020-10-22 Аркьюл, Инк. Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений
SG11201804601TA (en) * 2015-12-17 2018-07-30 Arqule Inc Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
US9847831B2 (en) 2016-04-08 2017-12-19 Ciena Corporation Dual wavelenth optical time domain reflectometer systems and methods embedded in a WDM system

Also Published As

Publication number Publication date
EP4019499A1 (en) 2022-06-29
EP3390369B1 (en) 2022-11-02
EA201891430A1 (ru) 2018-11-30
US10227311B2 (en) 2019-03-12
WO2017106642A1 (en) 2017-06-22
TWI796250B (zh) 2023-03-11
EA202091691A1 (ru) 2021-01-29
US20170174636A1 (en) 2017-06-22
EP3390369A1 (en) 2018-10-24
AU2022201947B2 (en) 2023-07-27
IL259556B2 (en) 2023-09-01
SG11201804670PA (en) 2018-07-30
TW202241854A (zh) 2022-11-01
US20200002293A1 (en) 2020-01-02
PH12020551465A1 (en) 2021-07-26
EP3390369A4 (en) 2019-08-14
US10717710B2 (en) 2020-07-21
NZ742695A (en) 2022-10-28
KR20180086508A (ko) 2018-07-31
IL259556A (en) 2018-07-31
AU2016369523B2 (en) 2021-12-23
MX385671B (es) 2025-03-18
MX2021000432A (es) 2022-07-28
AU2016369523A1 (en) 2018-06-07
CA3006081A1 (en) 2017-06-22
JP2018537499A (ja) 2018-12-20
AU2022201947A1 (en) 2022-04-14
JP2022031797A (ja) 2022-02-22
MX394320B (es) 2025-03-24
SA518391805B1 (ar) 2022-12-21
BR112018012095A2 (pt) 2018-11-27
US20180258055A1 (en) 2018-09-13
ES2935818T3 (es) 2023-03-10
MX2018007414A (es) 2018-11-09
US9981921B2 (en) 2018-05-29
TWI771280B (zh) 2022-07-21
PH12018501246A1 (en) 2019-02-04
IL259556B1 (en) 2023-05-01
CN108368061A (zh) 2018-08-03
TW201736352A (zh) 2017-10-16
EA036295B1 (ru) 2020-10-22

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