CN108368061A - 取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物的固体形式 - Google Patents

取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物的固体形式 Download PDF

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Publication number
CN108368061A
CN108368061A CN201680073181.8A CN201680073181A CN108368061A CN 108368061 A CN108368061 A CN 108368061A CN 201680073181 A CN201680073181 A CN 201680073181A CN 108368061 A CN108368061 A CN 108368061A
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CN
China
Prior art keywords
ray powder
powder diffraction
compound
polymorph
solid form
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Pending
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CN201680073181.8A
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English (en)
Chinese (zh)
Inventor
C.贝茨
D.P.里德
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Arqule Inc
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Arqule Inc
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Publication of CN108368061A publication Critical patent/CN108368061A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201680073181.8A 2015-12-17 2016-12-16 取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物的固体形式 Pending CN108368061A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562268747P 2015-12-17 2015-12-17
US62/268747 2015-12-17
PCT/US2016/067164 WO2017106642A1 (en) 2015-12-17 2016-12-16 Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds

Publications (1)

Publication Number Publication Date
CN108368061A true CN108368061A (zh) 2018-08-03

Family

ID=59057612

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680073181.8A Pending CN108368061A (zh) 2015-12-17 2016-12-16 取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物的固体形式

Country Status (19)

Country Link
US (3) US9981921B2 (https=)
EP (2) EP3390369B1 (https=)
JP (2) JP2018537499A (https=)
KR (1) KR20180086508A (https=)
CN (1) CN108368061A (https=)
AU (2) AU2016369523B2 (https=)
BR (1) BR112018012095A2 (https=)
CA (1) CA3006081A1 (https=)
EA (2) EA036295B1 (https=)
ES (1) ES2935818T3 (https=)
HK (1) HK1256825A1 (https=)
IL (1) IL259556B2 (https=)
MX (2) MX394320B (https=)
NZ (1) NZ742695A (https=)
PH (2) PH12018501246A1 (https=)
SA (1) SA518391805B1 (https=)
SG (1) SG11201804670PA (https=)
TW (2) TWI796250B (https=)
WO (1) WO2017106642A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201804601TA (en) 2015-12-17 2018-07-30 Arqule Inc Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
EA036295B1 (ru) * 2015-12-17 2020-10-22 Аркьюл, Инк. Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений
WO2022053708A1 (en) 2020-09-14 2022-03-17 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma
JP7641247B2 (ja) 2022-03-02 2025-03-06 日立建機株式会社 機械の性能診断装置

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028281A1 (en) * 1996-12-23 1998-07-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
US6133257A (en) * 1997-06-20 2000-10-17 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives
CN102325755A (zh) * 2008-12-30 2012-01-18 阿奎利公司 取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物
WO2012177852A1 (en) * 2011-06-24 2012-12-27 Arqule, Inc Substituted imidazopyridinyl compounds
US20150072959A1 (en) * 2006-12-29 2015-03-12 Rigel Pharmaceuticals, Inc. Substituted triazoles useful as axl inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
KR20070092994A (ko) * 2003-06-18 2007-09-14 테바 파마슈티컬 인더스트리즈 리미티드 플루바스타틴 나트륨 결정형 ｘｉｖ, ｌｘｘｉｉｉ,ｌｘｘｉｘ, ｌｘｘｘ 및 ｌｘｘｘｖｉｉ, 이의 제조 방법,이를 포함하는 조성물 및 이를 사용하는 방법
CN103476770B (zh) * 2010-11-25 2017-02-15 拉蒂欧制药有限责任公司 阿法替尼盐和多晶型物
US9802954B2 (en) * 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
JP2014530805A (ja) * 2011-09-30 2014-11-20 スンシネ ルアケ プハルマ カンパニー リミテッド アジルサルタンの結晶形並びにその製造及び使用
EA036295B1 (ru) * 2015-12-17 2020-10-22 Аркьюл, Инк. Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений
SG11201804601TA (en) * 2015-12-17 2018-07-30 Arqule Inc Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
US9847831B2 (en) 2016-04-08 2017-12-19 Ciena Corporation Dual wavelenth optical time domain reflectometer systems and methods embedded in a WDM system

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028281A1 (en) * 1996-12-23 1998-07-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
US6133257A (en) * 1997-06-20 2000-10-17 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives
US20150072959A1 (en) * 2006-12-29 2015-03-12 Rigel Pharmaceuticals, Inc. Substituted triazoles useful as axl inhibitors
CN102325755A (zh) * 2008-12-30 2012-01-18 阿奎利公司 取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物
WO2012177852A1 (en) * 2011-06-24 2012-12-27 Arqule, Inc Substituted imidazopyridinyl compounds

Also Published As

Publication number Publication date
EP4019499A1 (en) 2022-06-29
EP3390369B1 (en) 2022-11-02
EA201891430A1 (ru) 2018-11-30
US10227311B2 (en) 2019-03-12
WO2017106642A1 (en) 2017-06-22
TWI796250B (zh) 2023-03-11
EA202091691A1 (ru) 2021-01-29
US20170174636A1 (en) 2017-06-22
EP3390369A1 (en) 2018-10-24
AU2022201947B2 (en) 2023-07-27
IL259556B2 (en) 2023-09-01
SG11201804670PA (en) 2018-07-30
TW202241854A (zh) 2022-11-01
US20200002293A1 (en) 2020-01-02
PH12020551465A1 (en) 2021-07-26
EP3390369A4 (en) 2019-08-14
US10717710B2 (en) 2020-07-21
NZ742695A (en) 2022-10-28
KR20180086508A (ko) 2018-07-31
IL259556A (en) 2018-07-31
AU2016369523B2 (en) 2021-12-23
MX385671B (es) 2025-03-18
HK1256825A1 (zh) 2019-10-04
MX2021000432A (es) 2022-07-28
AU2016369523A1 (en) 2018-06-07
CA3006081A1 (en) 2017-06-22
JP2018537499A (ja) 2018-12-20
AU2022201947A1 (en) 2022-04-14
JP2022031797A (ja) 2022-02-22
MX394320B (es) 2025-03-24
SA518391805B1 (ar) 2022-12-21
BR112018012095A2 (pt) 2018-11-27
US20180258055A1 (en) 2018-09-13
ES2935818T3 (es) 2023-03-10
MX2018007414A (es) 2018-11-09
US9981921B2 (en) 2018-05-29
TWI771280B (zh) 2022-07-21
PH12018501246A1 (en) 2019-02-04
IL259556B1 (en) 2023-05-01
TW201736352A (zh) 2017-10-16
EA036295B1 (ru) 2020-10-22

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