EA201892475A1 - Оксабороловые сложные эфиры, их применение - Google Patents

Оксабороловые сложные эфиры, их применение

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Publication number
EA201892475A1
EA201892475A1 EA201892475A EA201892475A EA201892475A1 EA 201892475 A1 EA201892475 A1 EA 201892475A1 EA 201892475 A EA201892475 A EA 201892475A EA 201892475 A EA201892475 A EA 201892475A EA 201892475 A1 EA201892475 A1 EA 201892475A1
Authority
EA
Eurasian Patent Office
Prior art keywords
oxaborolic
application
complex ethers
ethers
complex
Prior art date
Application number
EA201892475A
Other languages
English (en)
Other versions
EA036661B1 (ru
Inventor
Цутому АКАМА
Дэвид Скотт Картер
Джейсон С. Холлэдэй
Роберт Т. Джейкобс
Ян Лю
Джейкоб Дж. Плэттнер
Юн-Кан Чзан
Майкл Джон Уитти
Original Assignee
Анакор Фармасьютикалс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Анакор Фармасьютикалс, Инк. filed Critical Анакор Фармасьютикалс, Инк.
Publication of EA201892475A1 publication Critical patent/EA201892475A1/ru
Publication of EA036661B1 publication Critical patent/EA036661B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)

Abstract

В настоящем изобретении предложены оксабороловые сложноэфирные соединения и их композиции, которые являются полезными в лечении заболеваний, связанных с паразитами, таких как болезнь Шагаса и африканский трипаносомоз животных.
EA201892475A 2016-05-12 2017-05-01 Оксабороловые сложные эфиры и способ лечения паразитической инфекции EA036661B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662335565P 2016-05-12 2016-05-12

Publications (2)

Publication Number Publication Date
EA201892475A1 true EA201892475A1 (ru) 2019-04-30
EA036661B1 EA036661B1 (ru) 2020-12-04

Family

ID=58699201

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201892475A EA036661B1 (ru) 2016-05-12 2017-05-01 Оксабороловые сложные эфиры и способ лечения паразитической инфекции
EA201892203A EA034415B1 (ru) 2016-05-12 2017-05-01 Оксабороловые сложные эфиры и их применения

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201892203A EA034415B1 (ru) 2016-05-12 2017-05-01 Оксабороловые сложные эфиры и их применения

Country Status (31)

Country Link
US (4) US10562921B2 (ru)
EP (2) EP3455227A1 (ru)
JP (2) JP6715957B2 (ru)
KR (2) KR102243775B1 (ru)
CN (2) CN109503637B (ru)
AR (2) AR108450A1 (ru)
AU (2) AU2017263785B2 (ru)
BR (2) BR122018076188A2 (ru)
CA (1) CA3023490C (ru)
CL (2) CL2018003187A1 (ru)
CO (1) CO2018012077A2 (ru)
CR (2) CR20180502A (ru)
DK (1) DK3578562T3 (ru)
EA (2) EA036661B1 (ru)
EC (2) ECSP18091065A (ru)
ES (1) ES2882782T3 (ru)
HK (1) HK1258717A1 (ru)
HU (1) HUE056320T2 (ru)
IL (2) IL262453A (ru)
MA (1) MA44968A (ru)
MX (2) MX2018013743A (ru)
NI (2) NI201801171A (ru)
NZ (1) NZ746906A (ru)
PE (2) PE20191077A1 (ru)
PT (1) PT3578562T (ru)
SG (1) SG11201809237RA (ru)
TN (2) TN2018000351A1 (ru)
TW (1) TWI629279B (ru)
UA (2) UA120999C2 (ru)
UY (2) UY37236A (ru)
WO (1) WO2017195069A1 (ru)

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US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
WO2017155879A1 (en) 2016-03-07 2017-09-14 Agrofresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
KR102243775B1 (ko) * 2016-05-12 2021-04-22 아나코르 파마슈티칼스 인코포레이티드 옥사보롤 에스터 및 이의 용도
MX2020005464A (es) 2017-11-30 2020-12-03 Boragen Inc Compuestos de benzoxaborol y formulaciones de los mismos.
JP2020180170A (ja) * 2019-04-23 2020-11-05 東ソー株式会社 ハロゲン含有ポリエーテルポリオール組成物

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EP3086645A1 (en) 2013-12-23 2016-11-02 Syngenta Participations AG Benzoxaborole fungicides
US20180244699A1 (en) * 2015-08-17 2018-08-30 Syngenta Participations Ag 1-hydroxy-3h-2,1-benzoxaborole derivatives and their use as microbiocides
KR102243775B1 (ko) * 2016-05-12 2021-04-22 아나코르 파마슈티칼스 인코포레이티드 옥사보롤 에스터 및 이의 용도

Also Published As

Publication number Publication date
MX2018015410A (es) 2019-05-27
TWI629279B (zh) 2018-07-11
CL2018003187A1 (es) 2019-01-11
US20210101916A1 (en) 2021-04-08
DK3578562T3 (da) 2021-07-12
KR102231489B1 (ko) 2021-03-23
KR20190002695A (ko) 2019-01-08
PE20191077A1 (es) 2019-08-20
US20200017531A1 (en) 2020-01-16
US10882872B2 (en) 2021-01-05
HUE056320T2 (hu) 2022-02-28
JP2019081770A (ja) 2019-05-30
SG11201809237RA (en) 2018-11-29
ECSP18091065A (es) 2019-07-31
UA121354C2 (uk) 2020-05-12
US20170327519A1 (en) 2017-11-16
UY37236A (es) 2018-01-02
UY37980A (es) 2020-06-30
IL262453A (en) 2018-12-31
IL263161B (en) 2022-05-01
CN109153688A (zh) 2019-01-04
NZ746906A (en) 2020-06-26
AU2018264116B2 (en) 2020-03-12
PT3578562T (pt) 2021-08-05
MX2018013743A (es) 2019-05-02
CR20180560A (es) 2019-01-25
AU2017263785A1 (en) 2018-10-25
PE20190119A1 (es) 2019-01-17
TN2018000351A1 (en) 2020-06-15
TN2019000106A1 (en) 2020-10-05
EA036661B1 (ru) 2020-12-04
CA3023490A1 (en) 2017-11-16
BR122018076188A2 (pt) 2019-09-10
EP3455227A1 (en) 2019-03-20
CN109503637B (zh) 2021-03-16
HK1258717A1 (zh) 2019-11-15
CA3023490C (en) 2021-06-08
TW201808968A (zh) 2018-03-16
KR20190005982A (ko) 2019-01-16
NI201801171A (es) 2019-04-10
ECSP19026702A (es) 2019-06-30
CO2018012077A2 (es) 2018-11-22
MA44968A (fr) 2019-03-20
ES2882782T3 (es) 2021-12-02
CN109503637A (zh) 2019-03-22
WO2017195069A1 (en) 2017-11-16
US10562921B2 (en) 2020-02-18
AR108450A1 (es) 2018-08-22
AR113543A2 (es) 2020-05-13
CR20180502A (es) 2018-12-21
JP6715957B2 (ja) 2020-07-01
EP3578562A1 (en) 2019-12-11
JP2019520326A (ja) 2019-07-18
US11578087B2 (en) 2023-02-14
JP6715966B2 (ja) 2020-07-01
KR102243775B1 (ko) 2021-04-22
EP3578562B1 (en) 2021-06-23
BR122023022427A2 (pt) 2023-12-26
AU2017263785B2 (en) 2019-10-03
NI201801172A (es) 2019-04-10
AU2018264116A1 (en) 2018-12-06
CL2018003377A1 (es) 2019-01-11
IL263161A (en) 2018-12-31
BR112018071931A2 (pt) 2019-02-05
UA120999C2 (uk) 2020-03-10
EA034415B1 (ru) 2020-02-05
EA201892203A1 (ru) 2019-04-30
US20230132298A1 (en) 2023-04-27

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