EA201890922A1 - Циклические простоэфирные производные пиразоло[1,5-а]пиримидин-3-карбоксамида - Google Patents

Циклические простоэфирные производные пиразоло[1,5-а]пиримидин-3-карбоксамида

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Publication number
EA201890922A1
EA201890922A1 EA201890922A EA201890922A EA201890922A1 EA 201890922 A1 EA201890922 A1 EA 201890922A1 EA 201890922 A EA201890922 A EA 201890922A EA 201890922 A EA201890922 A EA 201890922A EA 201890922 A1 EA201890922 A1 EA 201890922A1
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EA
Eurasian Patent Office
Prior art keywords
pyrazolo
carboxamide
prostofiry
pyrimidin
cyclic
Prior art date
Application number
EA201890922A
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English (en)
Other versions
EA035350B1 (ru
Inventor
Кристоф Хёнке
Барбара Бертани
Марко Феррара
Джакомо Фоссати
Сара Фраттини
Риккардо Джованнини
Скотт Хобсон
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
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Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201890922A1 publication Critical patent/EA201890922A1/ru
Publication of EA035350B1 publication Critical patent/EA035350B1/ru

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Abstract

Изобретение относится к спироциклическим простоэфирным производным пиразоло[1,5-a]пиримидин-3-карбоксамида общей формулы (I), которые являются ингибиторами фосфодиэстеразы 2, полезными при лечении заболеваний центральной нервной системы и других заболеваний. К тому же, изобретение относится к способам получения фармацевтических композиций, а также к способам получения соединений по изобретению.
EA201890922A 2015-10-13 2016-10-12 ЦИКЛИЧЕСКИЕ ЭФИРНЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛО[1,5-а]ПИРИМИДИН-3-КАРБОКСАМИДА EA035350B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15189600.8A EP3156405A1 (en) 2015-10-13 2015-10-13 Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
PCT/EP2016/074380 WO2017064082A1 (en) 2015-10-13 2016-10-12 Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide

Publications (2)

Publication Number Publication Date
EA201890922A1 true EA201890922A1 (ru) 2018-11-30
EA035350B1 EA035350B1 (ru) 2020-05-29

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EA201890922A EA035350B1 (ru) 2015-10-13 2016-10-12 ЦИКЛИЧЕСКИЕ ЭФИРНЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛО[1,5-а]ПИРИМИДИН-3-КАРБОКСАМИДА

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US (5) US10023575B2 (ru)
EP (2) EP3156405A1 (ru)
JP (1) JP6626965B2 (ru)
KR (1) KR102611558B1 (ru)
CN (2) CN108137602B (ru)
AU (1) AU2016338602B2 (ru)
BR (1) BR112018004347B1 (ru)
CA (1) CA3001929C (ru)
CL (1) CL2018000856A1 (ru)
CO (1) CO2018003756A2 (ru)
DK (1) DK3362453T3 (ru)
EA (1) EA035350B1 (ru)
ES (1) ES2912223T3 (ru)
HK (1) HK1254651A1 (ru)
HR (1) HRP20220595T1 (ru)
IL (1) IL258070B (ru)
LT (1) LT3362453T (ru)
MA (1) MA42988B1 (ru)
MX (1) MX2018004524A (ru)
MY (1) MY195169A (ru)
NZ (1) NZ740119A (ru)
PE (2) PE20181447A1 (ru)
PH (1) PH12018500796A1 (ru)
PL (1) PL3362453T3 (ru)
PT (1) PT3362453T (ru)
RS (1) RS63218B1 (ru)
SA (1) SA518391334B1 (ru)
SI (1) SI3362453T1 (ru)
UA (1) UA124576C2 (ru)
WO (1) WO2017064082A1 (ru)

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MX2018004524A (es) 2018-06-27
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