RS63218B1 - Ciklični etarski derivati pirazolo [1,5-a]pirimidin-3-karboksiamida - Google Patents

Ciklični etarski derivati pirazolo [1,5-a]pirimidin-3-karboksiamida

Info

Publication number
RS63218B1
RS63218B1 RS20220468A RSP20220468A RS63218B1 RS 63218 B1 RS63218 B1 RS 63218B1 RS 20220468 A RS20220468 A RS 20220468A RS P20220468 A RSP20220468 A RS P20220468A RS 63218 B1 RS63218 B1 RS 63218B1
Authority
RS
Serbia
Prior art keywords
carboxyamide
pyrazolo
pyrimidine
cyclic ether
ether derivatives
Prior art date
Application number
RS20220468A
Other languages
English (en)
Inventor
Christoph Hoenke
Barbara Bertani
Marco Ferrara
Giacomo Fossati
Sara Frattini
Riccardo Giovannini
Scott Hobson
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of RS63218B1 publication Critical patent/RS63218B1/sr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
RS20220468A 2015-10-13 2016-10-12 Ciklični etarski derivati pirazolo [1,5-a]pirimidin-3-karboksiamida RS63218B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15189600.8A EP3156405A1 (en) 2015-10-13 2015-10-13 Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
PCT/EP2016/074380 WO2017064082A1 (en) 2015-10-13 2016-10-12 Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide
EP16788047.5A EP3362453B1 (en) 2015-10-13 2016-10-12 Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide

Publications (1)

Publication Number Publication Date
RS63218B1 true RS63218B1 (sr) 2022-06-30

Family

ID=54293164

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20220468A RS63218B1 (sr) 2015-10-13 2016-10-12 Ciklični etarski derivati pirazolo [1,5-a]pirimidin-3-karboksiamida

Country Status (30)

Country Link
US (5) US10023575B2 (sr)
EP (2) EP3156405A1 (sr)
JP (1) JP6626965B2 (sr)
KR (1) KR102611558B1 (sr)
CN (2) CN114181213A (sr)
AU (1) AU2016338602B2 (sr)
BR (1) BR112018004347B1 (sr)
CA (1) CA3001929C (sr)
CL (1) CL2018000856A1 (sr)
CO (1) CO2018003756A2 (sr)
DK (1) DK3362453T3 (sr)
EA (1) EA035350B1 (sr)
ES (1) ES2912223T3 (sr)
HK (1) HK1254651A1 (sr)
HR (1) HRP20220595T1 (sr)
IL (1) IL258070B (sr)
LT (1) LT3362453T (sr)
MA (1) MA42988B1 (sr)
MX (1) MX2018004524A (sr)
MY (1) MY195169A (sr)
NZ (1) NZ740119A (sr)
PE (2) PE20190778A1 (sr)
PH (1) PH12018500796A1 (sr)
PL (1) PL3362453T3 (sr)
PT (1) PT3362453T (sr)
RS (1) RS63218B1 (sr)
SA (1) SA518391334B1 (sr)
SI (1) SI3362453T1 (sr)
UA (1) UA124576C2 (sr)
WO (1) WO2017064082A1 (sr)

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RU2671964C1 (ru) * 2017-08-30 2018-11-08 Сиа Эволед Пиразоло[1,5-а]пиримидинкарбоксилаты гадолиния и органические светодиоды на их основе
US11498928B2 (en) 2019-01-18 2022-11-15 Ascentage Pharma (Suzhou) Co., Ltd. Macrocyclic spiroethers as Mcl-1 inhibitors
CN110339197A (zh) * 2019-06-24 2019-10-18 中山大学 一种防治血管性痴呆的磷酸二酯酶9a抑制剂的用途

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US11691977B2 (en) 2023-07-04
AU2016338602A1 (en) 2018-03-15
CO2018003756A2 (es) 2018-07-10
CL2018000856A1 (es) 2018-07-27
EP3362453B1 (en) 2022-03-30
PH12018500796A1 (en) 2018-10-29
EP3156405A1 (en) 2017-04-19
HK1254651A1 (zh) 2019-07-26
KR102611558B1 (ko) 2023-12-11
US20200039991A1 (en) 2020-02-06
SI3362453T1 (sl) 2022-06-30
JP2018534279A (ja) 2018-11-22
MX2018004524A (es) 2018-06-27
BR112018004347A2 (pt) 2018-10-09
LT3362453T (lt) 2022-05-25
ES2912223T3 (es) 2022-05-25
SA518391334B1 (ar) 2021-03-29
CA3001929A1 (en) 2017-04-20
US10023575B2 (en) 2018-07-17
BR112018004347B1 (pt) 2023-12-05
NZ740119A (en) 2022-02-25
US20180134720A1 (en) 2018-05-17
IL258070A (en) 2018-05-31
CN108137602B (zh) 2021-09-28
PE20181447A1 (es) 2018-09-12
PL3362453T3 (pl) 2022-07-25
PE20190778A1 (es) 2019-06-06
CN114181213A (zh) 2022-03-15
HRP20220595T1 (hr) 2022-06-10
UA124576C2 (uk) 2021-10-13
EA035350B1 (ru) 2020-05-29
US10875867B2 (en) 2020-12-29
KR20180063316A (ko) 2018-06-11
EP3362453A1 (en) 2018-08-22
EA201890922A1 (ru) 2018-11-30
CN108137602A (zh) 2018-06-08
DK3362453T3 (da) 2022-06-07
US10479794B2 (en) 2019-11-19
MA42988B1 (fr) 2022-04-29
MA42988A (fr) 2021-04-07
AU2016338602B2 (en) 2020-07-16
IL258070B (en) 2020-06-30
US20170101411A1 (en) 2017-04-13
US20230286993A1 (en) 2023-09-14
JP6626965B2 (ja) 2019-12-25
US20210032259A1 (en) 2021-02-04
PT3362453T (pt) 2022-05-04
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WO2017064082A1 (en) 2017-04-20
MY195169A (en) 2023-01-11

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