EA201890738A1 - Комбинированная терапия, включающая канаглифлозин и фентермин, для лечения ожирения и связанных с ожирением расстройств - Google Patents

Комбинированная терапия, включающая канаглифлозин и фентермин, для лечения ожирения и связанных с ожирением расстройств

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Publication number
EA201890738A1
EA201890738A1 EA201890738A EA201890738A EA201890738A1 EA 201890738 A1 EA201890738 A1 EA 201890738A1 EA 201890738 A EA201890738 A EA 201890738A EA 201890738 A EA201890738 A EA 201890738A EA 201890738 A1 EA201890738 A1 EA 201890738A1
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EA
Eurasian Patent Office
Prior art keywords
progression
disorders
obesity
treating
cardiovascular
Prior art date
Application number
EA201890738A
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English (en)
Inventor
Норман Р. Розенталь
Пол Ротенберг
Дэвид К. Полидори
Дуглас К. Вэйс
Питер П. Стейн
Original Assignee
Янссен Фармацевтика Нв
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Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201890738A1 publication Critical patent/EA201890738A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение относится к применению комбинированной терапии, включающей введение канаглифлозина и фентермина, для лечения ожирения и связанных с ожирением расстройств. В частности, настоящее изобретение относится к комбинированной терапии для лечения ожирения, стимулирования снижения веса и/или подавления аппетита; для лечения, задержки, замедления прогрессирования и/или предотвращения расстройств обмена веществ (включая, например, сахарный диабет 2-го типа); для лечения, задержки, замедления прогрессирования и/или предотвращения заболеваний почек или жировой дистрофии печени (включая, например, неалкогольный стеатогепатит (NASH), неалкогольную жировую дистрофию печени (NAFLD) и пр.); для лечения, задержки, замедления прогрессирования и/или предотвращения расстройств сна (включая, например, апноэ во сне); для обеспечения защиты сердечно-сосудистой системы; для лечения, задержки, замедления прогрессирования и/или предотвращения сердечно-сосудистых явлений (в том числе тяжелых сердечно-сосудистых нежелательных явлений (MACE), например инфаркта миокарда, нестабильной стенокардии, смерти из-за сердечно-сосудистого заболевания, реваскуляризации, летального или нелетального расстройства мозгового кровообращения, периферической артериопатии, аортальных осложнений, госпитализации по причине застойной сердечной недостаточности и пр.) и/или для увеличения или продления продолжительности жизни.
EA201890738A 2015-09-15 2016-09-13 Комбинированная терапия, включающая канаглифлозин и фентермин, для лечения ожирения и связанных с ожирением расстройств EA201890738A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562218842P 2015-09-15 2015-09-15
US201662306110P 2016-03-10 2016-03-10
US15/262,038 US20170071970A1 (en) 2015-09-15 2016-09-12 Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
PCT/US2016/051435 WO2017048670A1 (en) 2015-09-15 2016-09-13 Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders

Publications (1)

Publication Number Publication Date
EA201890738A1 true EA201890738A1 (ru) 2018-10-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201890738A EA201890738A1 (ru) 2015-09-15 2016-09-13 Комбинированная терапия, включающая канаглифлозин и фентермин, для лечения ожирения и связанных с ожирением расстройств

Country Status (18)

Country Link
US (3) US20170071970A1 (ru)
EP (1) EP3349740B1 (ru)
JP (1) JP2018527374A (ru)
KR (1) KR20180051560A (ru)
CN (1) CN108024977A (ru)
AU (1) AU2016322537B2 (ru)
CA (1) CA2998730A1 (ru)
CO (1) CO2018002708A2 (ru)
EA (1) EA201890738A1 (ru)
ES (1) ES2873117T3 (ru)
HK (1) HK1248124A1 (ru)
IL (1) IL257876A (ru)
MX (1) MX2018003261A (ru)
PH (1) PH12018500501A1 (ru)
TW (1) TW201722413A (ru)
UA (1) UA122974C2 (ru)
WO (1) WO2017048670A1 (ru)
ZA (1) ZA201802448B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI835735B (zh) * 2017-06-12 2024-03-21 比利時商健生藥品公司 減少或預防第ii型糖尿病患者中心血管事件之方法
CN110038009B (zh) * 2019-05-13 2021-01-08 浙江大学 卡格列净在制备抗肿瘤药物中的应用
AU2021208601A1 (en) * 2020-02-18 2022-07-28 Novo Nordisk A/S Glp-1 compositions and uses thereof
CN112716940A (zh) * 2021-02-18 2021-04-30 苏州大学 卡格列净在制备治疗与stat6蛋白相关疾病的药物中的应用
CN113812378B (zh) * 2021-09-29 2023-02-03 湖北天勤生物技术研究院有限公司 一种食蟹猴肥胖症模型的建立方法及其应用
CN113893349B (zh) * 2021-12-13 2022-07-22 北京大学第三医院（北京大学第三临床医学院） 达格列净及其类似物在制备防治雄性生殖功能障碍的药物中的用途

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US20190142855A1 (en) 2019-05-16
WO2017048670A1 (en) 2017-03-23
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IL257876A (en) 2018-05-31
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US20170071970A1 (en) 2017-03-16
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US11207337B2 (en) 2021-12-28
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