EA201791802A1 - СШИТЫЕ ДИГИДРО-4H-ПИРАЗОЛО[5,1-c][1,4]ОКСАЗИНИЛОВЫЕ СОЕДИНЕНИЯ И АНАЛОГИ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ ЦНС - Google Patents

СШИТЫЕ ДИГИДРО-4H-ПИРАЗОЛО[5,1-c][1,4]ОКСАЗИНИЛОВЫЕ СОЕДИНЕНИЯ И АНАЛОГИ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ ЦНС

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Publication number
EA201791802A1
EA201791802A1 EA201791802A EA201791802A EA201791802A1 EA 201791802 A1 EA201791802 A1 EA 201791802A1 EA 201791802 A EA201791802 A EA 201791802A EA 201791802 A EA201791802 A EA 201791802A EA 201791802 A1 EA201791802 A1 EA 201791802A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
treatment
oxasynyl
pyrazolo
analogues
Prior art date
Application number
EA201791802A
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English (en)
Russian (ru)
Inventor
Майлан ЧИТИЛ
Шарон Энгел
Талин Дж. ХАНАНИЯ
Вадим Александров
Эмер Лихи
Original Assignee
Суновион Фармасьютикалз Инк.
ПиДжиАй Драг Дискавери ЭлЭлСи
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Publication of EA201791802A1 publication Critical patent/EA201791802A1/ru

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
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    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
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    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EA201791802A 2015-02-11 2016-02-11 СШИТЫЕ ДИГИДРО-4H-ПИРАЗОЛО[5,1-c][1,4]ОКСАЗИНИЛОВЫЕ СОЕДИНЕНИЯ И АНАЛОГИ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ ЦНС EA201791802A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562115043P 2015-02-11 2015-02-11
PCT/US2016/017527 WO2016130790A1 (en) 2015-02-11 2016-02-11 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders

Publications (1)

Publication Number Publication Date
EA201791802A1 true EA201791802A1 (ru) 2018-02-28

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EP (3) EP3256476B1 (enExample)
JP (4) JP6561128B2 (enExample)
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CN (2) CN111171047B (enExample)
AU (4) AU2016219247B2 (enExample)
BR (1) BR112017017349B1 (enExample)
CA (1) CA2976092A1 (enExample)
DK (1) DK3256476T3 (enExample)
EA (1) EA201791802A1 (enExample)
ES (1) ES2712627T3 (enExample)
IL (2) IL253907B (enExample)
MX (1) MX371197B (enExample)
NZ (1) NZ734972A (enExample)
PH (1) PH12017501423A1 (enExample)
PL (1) PL3256476T3 (enExample)
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UA (1) UA123262C2 (enExample)
WO (1) WO2016130790A1 (enExample)
ZA (1) ZA201706074B (enExample)

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JP7187437B2 (ja) 2016-07-29 2022-12-12 サノビオン ファーマシューティカルズ インク 化合物および組成物ならびにそれらの使用
EP3490607A4 (en) 2016-07-29 2020-04-08 Sunovion Pharmaceuticals Inc. COMPOUNDS AND COMPOSITIONS, AND USES THEREOF
KR101753092B1 (ko) 2016-12-14 2017-07-04 성일하이텍(주) 리튬 함유 폐액으로부터 인산리튬 제조방법
US10850989B2 (en) 2016-12-20 2020-12-01 Sungeel Hitech Co., Ltd. Method for preparing solid lithium salt from lithium solution
EA202090180A1 (ru) * 2017-06-30 2020-05-26 Чейс Терапьютикс Корпорейшн Композиции nk1-антагониста и способы лечения депрессии
SG11202000669VA (en) 2017-08-02 2020-02-27 Sunovion Pharmaceuticals Inc Isochroman compounds and uses thereof
WO2019236808A1 (en) 2018-06-07 2019-12-12 Sunovion Pharmaceuticals Inc. Salts of a oxazino[4,3-b]indazole derivative and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
KR20210139376A (ko) 2019-03-14 2021-11-22 선오비온 파마슈티컬스 인코포레이티드 이소크로마닐 화합물의 염, 및 이의 결정성 형태, 제조방법, 치료 용도 및 약제학적 조성물
TW202237622A (zh) * 2020-12-04 2022-10-01 美商蘇諾維恩藥業公司 雜環化合物的鹽及其晶型、製備方法、治療用途與醫藥組合物
WO2022217233A1 (en) * 2021-04-08 2022-10-13 Sunovion Pharmaceuticals Inc. Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders
US20240417378A1 (en) * 2021-10-11 2024-12-19 Baylor College Of Medicine G-protein-coupled receptor regulators and methods of use thereof

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KR102623321B1 (ko) * 2015-02-11 2024-01-09 선오비온 파마슈티컬스 인코포레이티드 중추 신경계 질환을 치료하기 위한 융합된 다이하이드로-4h-피라졸로[5,1-c][1,4]옥사진일 화합물 및 유사체

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US20210300942A1 (en) 2021-09-30
CN111171047A (zh) 2020-05-19
CA2976092A1 (en) 2016-08-18
CN107567454A (zh) 2018-01-09
ZA201706074B (en) 2023-05-31
CN111171047B (zh) 2023-06-23
JP6928629B2 (ja) 2021-09-01
AU2016219247B2 (en) 2020-08-13
ES2712627T3 (es) 2019-05-14
PH12017501423A1 (en) 2018-03-19
US20200024286A1 (en) 2020-01-23
SG11201706516WA (en) 2017-09-28
IL253907A0 (en) 2017-10-31
DK3256476T3 (en) 2019-03-11
AU2022259828A1 (en) 2022-12-01
JP2021183624A (ja) 2021-12-02
IL277658A (en) 2020-11-30
WO2016130790A1 (en) 2016-08-18
AU2020267209A1 (en) 2020-12-10
BR112017017349A2 (en) 2018-04-10
EP4006039B1 (en) 2024-01-10
US20180057506A1 (en) 2018-03-01
UA123262C2 (uk) 2021-03-10
IL277658B (en) 2022-03-01
KR20170129729A (ko) 2017-11-27
AU2024204310A1 (en) 2024-07-11
EP4006039A1 (en) 2022-06-01
PT3256476T (pt) 2019-03-01
NZ734972A (en) 2023-07-28
US9758529B2 (en) 2017-09-12
JP2018505204A (ja) 2018-02-22
EP3256476A1 (en) 2017-12-20
JP6561128B2 (ja) 2019-08-14
JP2023036611A (ja) 2023-03-14
KR102623321B1 (ko) 2024-01-09
EP3539967A1 (en) 2019-09-18
JP2019196385A (ja) 2019-11-14
EP3256476B1 (en) 2019-01-23
MX371197B (es) 2020-01-22
MX2017010362A (es) 2018-05-04
BR112017017349B1 (pt) 2024-01-23
IL253907B (en) 2020-09-30
US20160264597A1 (en) 2016-09-15
CN107567454B (zh) 2020-02-18
PL3256476T3 (pl) 2019-05-31
AU2016219247A1 (en) 2017-09-21

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