AU2016219247B2 - Fused dihydro-4H-pyrazolo[5,1-C][1,4]oxazinyl compounds and analogs for treating CNS disorders - Google Patents

Fused dihydro-4H-pyrazolo[5,1-C][1,4]oxazinyl compounds and analogs for treating CNS disorders Download PDF

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Publication number
AU2016219247B2
AU2016219247B2 AU2016219247A AU2016219247A AU2016219247B2 AU 2016219247 B2 AU2016219247 B2 AU 2016219247B2 AU 2016219247 A AU2016219247 A AU 2016219247A AU 2016219247 A AU2016219247 A AU 2016219247A AU 2016219247 B2 AU2016219247 B2 AU 2016219247B2
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compound
pharmaceutically acceptable
acceptable salt
boc
formula
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AU2016219247A1 (en
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Vadim ALEXANDROV
Milan Chytil
Sharon Engel
Taleen G. Hanania
Emer Leahy
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Sunovion Pharmaceuticals Inc
PGI Drug Discovery LLC
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Sunovion Pharmaceuticals Inc
PGI Drug Discovery LLC
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Priority to AU2022259828A priority patent/AU2022259828A1/en
Priority to AU2024204310A priority patent/AU2024204310A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2016219247A 2015-02-11 2016-02-11 Fused dihydro-4H-pyrazolo[5,1-C][1,4]oxazinyl compounds and analogs for treating CNS disorders Expired - Fee Related AU2016219247B2 (en)

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AU2020267209A AU2020267209A1 (en) 2015-02-11 2020-11-11 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders
AU2022259828A AU2022259828A1 (en) 2015-02-11 2022-10-28 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders
AU2024204310A AU2024204310A1 (en) 2015-02-11 2024-06-24 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders

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US201562115043P 2015-02-11 2015-02-11
US62/115,043 2015-02-11
PCT/US2016/017527 WO2016130790A1 (en) 2015-02-11 2016-02-11 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders

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AU2016219247A1 AU2016219247A1 (en) 2017-09-21
AU2016219247B2 true AU2016219247B2 (en) 2020-08-13

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AU2016219247A Expired - Fee Related AU2016219247B2 (en) 2015-02-11 2016-02-11 Fused dihydro-4H-pyrazolo[5,1-C][1,4]oxazinyl compounds and analogs for treating CNS disorders
AU2020267209A Abandoned AU2020267209A1 (en) 2015-02-11 2020-11-11 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders
AU2022259828A Abandoned AU2022259828A1 (en) 2015-02-11 2022-10-28 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders
AU2024204310A Abandoned AU2024204310A1 (en) 2015-02-11 2024-06-24 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders

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AU2020267209A Abandoned AU2020267209A1 (en) 2015-02-11 2020-11-11 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders
AU2022259828A Abandoned AU2022259828A1 (en) 2015-02-11 2022-10-28 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders
AU2024204310A Abandoned AU2024204310A1 (en) 2015-02-11 2024-06-24 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders

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KR20210139376A (ko) 2019-03-14 2021-11-22 선오비온 파마슈티컬스 인코포레이티드 이소크로마닐 화합물의 염, 및 이의 결정성 형태, 제조방법, 치료 용도 및 약제학적 조성물
TW202237622A (zh) * 2020-12-04 2022-10-01 美商蘇諾維恩藥業公司 雜環化合物的鹽及其晶型、製備方法、治療用途與醫藥組合物
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CN111171047A (zh) 2020-05-19
CA2976092A1 (en) 2016-08-18
CN107567454A (zh) 2018-01-09
ZA201706074B (en) 2023-05-31
CN111171047B (zh) 2023-06-23
EA201791802A1 (ru) 2018-02-28
JP6928629B2 (ja) 2021-09-01
ES2712627T3 (es) 2019-05-14
PH12017501423A1 (en) 2018-03-19
US20200024286A1 (en) 2020-01-23
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IL253907A0 (en) 2017-10-31
DK3256476T3 (en) 2019-03-11
AU2022259828A1 (en) 2022-12-01
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IL277658A (en) 2020-11-30
WO2016130790A1 (en) 2016-08-18
AU2020267209A1 (en) 2020-12-10
BR112017017349A2 (en) 2018-04-10
EP4006039B1 (en) 2024-01-10
US20180057506A1 (en) 2018-03-01
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