AU2016219247B2 - Fused dihydro-4H-pyrazolo[5,1-C][1,4]oxazinyl compounds and analogs for treating CNS disorders - Google Patents

Fused dihydro-4H-pyrazolo[5,1-C][1,4]oxazinyl compounds and analogs for treating CNS disorders Download PDF

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Publication number
AU2016219247B2
AU2016219247B2 AU2016219247A AU2016219247A AU2016219247B2 AU 2016219247 B2 AU2016219247 B2 AU 2016219247B2 AU 2016219247 A AU2016219247 A AU 2016219247A AU 2016219247 A AU2016219247 A AU 2016219247A AU 2016219247 B2 AU2016219247 B2 AU 2016219247B2
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compound
pharmaceutically acceptable
acceptable salt
boc
formula
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Expired - Fee Related
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AU2016219247A1 (en
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Vadim ALEXANDROV
Milan Chytil
Sharon Engel
Taleen G. Hanania
Emer Leahy
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PGI Drug Discovery LLC
Sumitomo Pharma America Inc
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Sunovion Pharmaceuticals Inc
PGI Drug Discovery LLC
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Priority to AU2020267209A priority Critical patent/AU2020267209A1/en
Priority to AU2022259828A priority patent/AU2022259828A1/en
Priority to AU2024204310A priority patent/AU2024204310A1/en
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/16—Anti-Parkinson drugs
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Child & Adolescent Psychology (AREA)
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  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2016219247A 2015-02-11 2016-02-11 Fused dihydro-4H-pyrazolo[5,1-C][1,4]oxazinyl compounds and analogs for treating CNS disorders Expired - Fee Related AU2016219247B2 (en)

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AU2020267209A AU2020267209A1 (en) 2015-02-11 2020-11-11 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders
AU2022259828A AU2022259828A1 (en) 2015-02-11 2022-10-28 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders
AU2024204310A AU2024204310A1 (en) 2015-02-11 2024-06-24 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders

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US201562115043P 2015-02-11 2015-02-11
US62/115,043 2015-02-11
PCT/US2016/017527 WO2016130790A1 (en) 2015-02-11 2016-02-11 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders

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AU2016219247B2 true AU2016219247B2 (en) 2020-08-13

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AU2016219247A Expired - Fee Related AU2016219247B2 (en) 2015-02-11 2016-02-11 Fused dihydro-4H-pyrazolo[5,1-C][1,4]oxazinyl compounds and analogs for treating CNS disorders
AU2020267209A Abandoned AU2020267209A1 (en) 2015-02-11 2020-11-11 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders
AU2022259828A Abandoned AU2022259828A1 (en) 2015-02-11 2022-10-28 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders
AU2024204310A Abandoned AU2024204310A1 (en) 2015-02-11 2024-06-24 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders

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AU2022259828A Abandoned AU2022259828A1 (en) 2015-02-11 2022-10-28 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders
AU2024204310A Abandoned AU2024204310A1 (en) 2015-02-11 2024-06-24 Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders

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BR112019001407A2 (pt) 2016-07-29 2019-07-09 Sunovion Pharmaceuticals Inc. compostos e composições e usos dos mesmos
KR101753092B1 (ko) 2016-12-14 2017-07-04 성일하이텍(주) 리튬 함유 폐액으로부터 인산리튬 제조방법
US10850989B2 (en) 2016-12-20 2020-12-01 Sungeel Hitech Co., Ltd. Method for preparing solid lithium salt from lithium solution
AU2018258117A1 (en) 2017-04-24 2019-12-12 Chase Therapeutics Corporation Compositions and method for treating depression
AU2018290889B2 (en) 2017-06-30 2024-06-27 Alto Neuroscience, Inc. NK-1 antagonist compositions and methods for use in treating depression
MX2020000523A (es) 2017-08-02 2020-08-20 Sunovion Pharmaceuticals Inc Compuestos de isocromano y usos de los mismos.
US20190375764A1 (en) 2018-06-07 2019-12-12 Sunovion Pharmaceuticals Inc. Salts of a heterocyclic compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
JP7703449B2 (ja) 2019-03-14 2025-07-07 スミトモ・ファーマ・アメリカ・インコーポレイテッド イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物
TW202237622A (zh) 2020-12-04 2022-10-01 美商蘇諾維恩藥業公司 雜環化合物的鹽及其晶型、製備方法、治療用途與醫藥組合物
US20240158416A1 (en) * 2021-04-08 2024-05-16 Sumitomo Pharma America, Inc. Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders
US20240417378A1 (en) * 2021-10-11 2024-12-19 Baylor College Of Medicine G-protein-coupled receptor regulators and methods of use thereof

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WO2016130790A1 (en) 2016-08-18
JP6561128B2 (ja) 2019-08-14
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CN107567454A (zh) 2018-01-09
CN111171047B (zh) 2023-06-23
DK3256476T3 (en) 2019-03-11
US20210300942A1 (en) 2021-09-30
MX371197B (es) 2020-01-22
US9758529B2 (en) 2017-09-12
CN107567454B (zh) 2020-02-18
KR102623321B1 (ko) 2024-01-09
AU2016219247A1 (en) 2017-09-21
EP3539967A1 (en) 2019-09-18
PL3256476T3 (pl) 2019-05-31
AU2020267209A1 (en) 2020-12-10
BR112017017349A2 (en) 2018-04-10
BR112017017349B1 (pt) 2024-01-23
US20160264597A1 (en) 2016-09-15
ZA201706074B (en) 2023-05-31
EA201791802A1 (ru) 2018-02-28
US20180057506A1 (en) 2018-03-01
JP2018505204A (ja) 2018-02-22
JP6928629B2 (ja) 2021-09-01
PT3256476T (pt) 2019-03-01
JP2019196385A (ja) 2019-11-14
CA2976092A1 (en) 2016-08-18
CN111171047A (zh) 2020-05-19
SG11201706516WA (en) 2017-09-28
IL253907A0 (en) 2017-10-31
EP3256476B1 (en) 2019-01-23
UA123262C2 (uk) 2021-03-10
IL277658B (en) 2022-03-01
KR20170129729A (ko) 2017-11-27
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US20200024286A1 (en) 2020-01-23
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