EA201692306A1 - Способ - Google Patents

Способ

Info

Publication number
EA201692306A1
EA201692306A1 EA201692306A EA201692306A EA201692306A1 EA 201692306 A1 EA201692306 A1 EA 201692306A1 EA 201692306 A EA201692306 A EA 201692306A EA 201692306 A EA201692306 A EA 201692306A EA 201692306 A1 EA201692306 A1 EA 201692306A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
formula
alkynyl
alkenyl
halogen
Prior art date
Application number
EA201692306A
Other languages
English (en)
Other versions
EA033494B1 (ru
Inventor
Андреа Файни
Марко Форцатти
Джованни Фольято
Стефано Бьонди
Original Assignee
Аллекра Терапьютикс Сас
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аллекра Терапьютикс Сас filed Critical Аллекра Терапьютикс Сас
Publication of EA201692306A1 publication Critical patent/EA201692306A1/ru
Publication of EA033494B1 publication Critical patent/EA033494B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/87—Compounds being unsubstituted in position 3 or with substituents other than only two methyl radicals attached in position 3, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Способ получения соединений формулы (IIIa), где Rв каждом случае независимо выбран из Н, галогена, амино, C-алкила, C-алкенила и C-алкинила; Rв каждом случае независимо выбран из Н, галогена, амино, C-алкила, C-алкенила и C-алкинила; Rозначает C-алкил; Rозначает C-фторалкил; a PG означает защитную группу; который включает стадию взаимодействия соединения формулы (IIa) с соединением формулы (VIII).
EA201692306A 2014-05-15 2015-05-14 Способ получения метиловых производных пенама EA033494B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1408649.0A GB201408649D0 (en) 2014-05-15 2014-05-15 Method
PCT/EP2015/060733 WO2015173378A2 (en) 2014-05-15 2015-05-14 Method

Publications (2)

Publication Number Publication Date
EA201692306A1 true EA201692306A1 (ru) 2017-05-31
EA033494B1 EA033494B1 (ru) 2019-10-31

Family

ID=51134924

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201991629A EA201991629A3 (ru) 2014-05-15 2015-05-14 Способ
EA201692306A EA033494B1 (ru) 2014-05-15 2015-05-14 Способ получения метиловых производных пенама

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201991629A EA201991629A3 (ru) 2014-05-15 2015-05-14 Способ

Country Status (29)

Country Link
US (1) US9963465B2 (ru)
EP (3) EP3143028B1 (ru)
JP (1) JP6613303B2 (ru)
KR (1) KR102329186B1 (ru)
CN (1) CN106459086B (ru)
AU (1) AU2015261416B2 (ru)
BR (1) BR112016026074B1 (ru)
CA (1) CA2945900C (ru)
CL (2) CL2016002880A1 (ru)
CR (1) CR20160580A (ru)
CY (2) CY1120957T1 (ru)
DK (2) DK3231806T3 (ru)
EA (2) EA201991629A3 (ru)
EC (1) ECSP16085143A (ru)
ES (2) ES2725675T3 (ru)
GB (1) GB201408649D0 (ru)
HR (2) HRP20182065T1 (ru)
HU (1) HUE044511T2 (ru)
IL (1) IL248834B (ru)
LT (2) LT3231806T (ru)
MX (1) MX2016014644A (ru)
PE (1) PE20161433A1 (ru)
PL (2) PL3231806T3 (ru)
PT (2) PT3231806T (ru)
RS (2) RS58748B1 (ru)
SG (1) SG11201609494YA (ru)
SI (2) SI3231806T1 (ru)
TR (1) TR201906867T4 (ru)
WO (1) WO2015173378A2 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201319776D0 (en) * 2013-11-08 2013-12-25 Allecra Therapeutics Sas Compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1319776A (en) 1969-07-15 1973-06-06 Yorkshire Chemicals Ltd Basic dyes
EP2046802B1 (en) * 2006-07-12 2013-08-21 Allecra Therapeutics GmbH 2-substituted methyl penam derivatives
AP2013006947A0 (en) * 2010-11-25 2013-06-30 Orchid Chemicals & Pharm Ltd Compounds and their use
KR20120067257A (ko) * 2010-12-15 2012-06-25 서강대학교산학협력단 3-메틸-1,4-치환된 1,2,3-트라이아졸륨 기반의 이온성 액체 및 그의 제조방법과 응용

Also Published As

Publication number Publication date
BR112016026074A8 (pt) 2021-03-30
KR20170002466A (ko) 2017-01-06
CN106459086A (zh) 2017-02-22
EP3143028B1 (en) 2018-09-26
JP2017515907A (ja) 2017-06-15
LT3231806T (lt) 2019-05-27
DK3231806T3 (da) 2019-05-20
RS58748B1 (sr) 2019-06-28
SG11201609494YA (en) 2016-12-29
CN106459086B (zh) 2018-11-13
NZ725121A (en) 2023-09-29
KR102329186B1 (ko) 2021-11-22
ES2699644T3 (es) 2019-02-12
WO2015173378A3 (en) 2016-01-14
SI3231806T1 (sl) 2019-06-28
AU2015261416A1 (en) 2016-11-10
CL2018001961A1 (es) 2018-08-31
EP3231806B1 (en) 2019-02-13
US9963465B2 (en) 2018-05-08
RS58430B1 (sr) 2019-04-30
CY1120957T1 (el) 2019-12-11
DK3143028T3 (da) 2019-01-02
PL3231806T3 (pl) 2019-08-30
EA201991629A2 (ru) 2019-12-30
CL2016002880A1 (es) 2017-06-16
AU2015261416B2 (en) 2019-07-11
IL248834A0 (en) 2017-01-31
LT3143028T (lt) 2018-12-27
GB201408649D0 (en) 2014-07-02
HUE044511T2 (hu) 2019-10-28
EA201991629A3 (ru) 2020-02-28
EP3143028A2 (en) 2017-03-22
HRP20182065T1 (hr) 2019-02-08
US20170101421A1 (en) 2017-04-13
CR20160580A (es) 2017-05-09
EA033494B1 (ru) 2019-10-31
EP3231806A1 (en) 2017-10-18
HRP20190830T1 (hr) 2019-06-28
MX2016014644A (es) 2017-02-23
PT3231806T (pt) 2019-05-30
TR201906867T4 (tr) 2019-05-21
PT3143028T (pt) 2018-12-17
BR112016026074B1 (pt) 2023-01-03
PE20161433A1 (es) 2017-01-18
CA2945900C (en) 2023-01-24
ECSP16085143A (es) 2017-05-31
ES2725675T3 (es) 2019-09-26
SI3143028T1 (sl) 2019-01-31
JP6613303B2 (ja) 2019-11-27
WO2015173378A2 (en) 2015-11-19
PL3143028T3 (pl) 2019-04-30
CA2945900A1 (en) 2015-11-19
IL248834B (en) 2019-05-30
CY1121756T1 (el) 2020-07-31
EP3441395A1 (en) 2019-02-13

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