EA201591216A1 - Композиции, содержащие хондроитина сульфат, протеолитические ферменты и сульфгидрильные соединения для улучшения биодоступности хондроитина сульфата - Google Patents

Композиции, содержащие хондроитина сульфат, протеолитические ферменты и сульфгидрильные соединения для улучшения биодоступности хондроитина сульфата

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Publication number
EA201591216A1
EA201591216A1 EA201591216A EA201591216A EA201591216A1 EA 201591216 A1 EA201591216 A1 EA 201591216A1 EA 201591216 A EA201591216 A EA 201591216A EA 201591216 A EA201591216 A EA 201591216A EA 201591216 A1 EA201591216 A1 EA 201591216A1
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EA
Eurasian Patent Office
Prior art keywords
cholesterol
samples
sulfhydryl compounds
biodatability
improve
Prior art date
Application number
EA201591216A
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English (en)
Other versions
EA030130B1 (ru
Inventor
Никколо Миралья
Мауро Россини
Давиде Бьянки
Антонелла Трентин
Original Assignee
Гносис С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Гносис С.п.А. filed Critical Гносис С.п.А.
Publication of EA201591216A1 publication Critical patent/EA201591216A1/ru
Publication of EA030130B1 publication Critical patent/EA030130B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Botany (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В настоящем изобретении описаны комбинации, содержащие хондроитина сульфат (ХС), один(ну) или более ферментов или ферментных смесей, обладающих протеолитической активностью, и сульфгидрильные соединения, для лечения и предупреждения остеоартрита и ассоциированных острых и хронических воспалительных процессов или в качестве нутрицевтических композиций для поддержания здоровья костно-мышечной системы у людей и животных. Особенность указанных комбинаций заключается в том, что они увеличивают кишечную абсорбцию ХС при пероральном введении. Эффект указанных комбинаций проявляется в широком диапазоне молекулярных масс ХС, включая образцы ХС с очень низкими молекулярными массами, которые уже обладают большей биодоступностью, чем образцы с более высокой молекулярной массой. Эффект проявляется у образцов ХС любого происхождения.
EA201591216A 2013-01-25 2014-01-23 Композиции, содержащие хондроитина сульфат и наттокиназу, для улучшения биодоступности хондроитина сульфата EA030130B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000117A ITMI20130117A1 (it) 2013-01-25 2013-01-25 Composizioni comprendenti condroitin solfato, enzimi proteolitici e composti sulfidrilati capaci di migliorare la biodisponibilita' del condroitin solfato
PCT/EP2014/051308 WO2014114706A1 (en) 2013-01-25 2014-01-23 Compositions containing chondroitin sulphate, proteolytic enzymes and sulphydryl compounds for improving the bioavailability of chondroitin sulphate

Publications (2)

Publication Number Publication Date
EA201591216A1 true EA201591216A1 (ru) 2016-01-29
EA030130B1 EA030130B1 (ru) 2018-06-29

Family

ID=47749928

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EA201591216A EA030130B1 (ru) 2013-01-25 2014-01-23 Композиции, содержащие хондроитина сульфат и наттокиназу, для улучшения биодоступности хондроитина сульфата

Country Status (27)

Country Link
US (1) US20150366978A1 (ru)
EP (1) EP2948160B1 (ru)
JP (1) JP6348123B2 (ru)
KR (1) KR102235577B1 (ru)
CN (1) CN105101985B (ru)
AU (1) AU2014209961B2 (ru)
BR (1) BR112015017544B1 (ru)
CA (1) CA2899129C (ru)
CY (1) CY1118433T1 (ru)
DK (1) DK2948160T3 (ru)
EA (1) EA030130B1 (ru)
ES (1) ES2616017T3 (ru)
GE (1) GEP201706673B (ru)
HR (1) HRP20170198T1 (ru)
HU (1) HUE033162T2 (ru)
IL (1) IL240108B (ru)
IT (1) ITMI20130117A1 (ru)
LT (1) LT2948160T (ru)
MX (1) MX359136B (ru)
NZ (1) NZ710337A (ru)
PH (1) PH12015501474B1 (ru)
PL (1) PL2948160T3 (ru)
PT (1) PT2948160T (ru)
SI (1) SI2948160T1 (ru)
UA (1) UA114941C2 (ru)
WO (1) WO2014114706A1 (ru)
ZA (1) ZA201505322B (ru)

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CN106215176A (zh) * 2016-08-22 2016-12-14 安徽瑞达健康产业投资有限公司 一种高效抗炎多酶组合物
CN108741099A (zh) * 2018-06-11 2018-11-06 广州尚天诚品生物科技有限公司 一种有助于关节舒适的营养组合物及其制备方法和应用
KR102231289B1 (ko) * 2018-12-26 2021-03-23 (주)휴온스 고함량 콘드로이틴설페이트 약학 제제 및 이의 제조방법
CN111744018A (zh) * 2019-03-26 2020-10-09 北京福元医药股份有限公司 一种盐酸氨基葡萄糖药物制剂
CN112741272B (zh) * 2021-01-18 2023-02-28 黑龙江中医药大学 一种高含量纳豆激酶的纳豆冻干粉的发酵方法
IT202100030935A1 (it) 2021-12-09 2023-06-09 Fidia Farm Spa Compresse comprendenti condroitin solfato, glucosamina cloridrato e vitamina c per il trattamento di danni cartilaginei, tendinei, ossei

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Also Published As

Publication number Publication date
WO2014114706A1 (en) 2014-07-31
JP2016505060A (ja) 2016-02-18
US20150366978A1 (en) 2015-12-24
AU2014209961B2 (en) 2018-05-17
PT2948160T (pt) 2017-02-17
AU2014209961A1 (en) 2015-08-13
LT2948160T (lt) 2017-02-10
CY1118433T1 (el) 2017-06-28
ITMI20130117A1 (it) 2014-07-26
MX359136B (es) 2018-09-14
CA2899129A1 (en) 2014-07-31
PH12015501474A1 (en) 2015-09-21
UA114941C2 (uk) 2017-08-28
KR102235577B1 (ko) 2021-04-06
KR20150111351A (ko) 2015-10-05
GEP201706673B (en) 2017-05-25
CN105101985B (zh) 2018-02-23
PL2948160T3 (pl) 2017-05-31
EP2948160B1 (en) 2016-11-16
BR112015017544A2 (pt) 2017-07-11
CA2899129C (en) 2023-01-17
CN105101985A (zh) 2015-11-25
ZA201505322B (en) 2016-10-26
ES2616017T3 (es) 2017-06-09
EP2948160A1 (en) 2015-12-02
PH12015501474B1 (en) 2015-09-21
MX2015009544A (es) 2015-11-25
BR112015017544B1 (pt) 2023-04-25
JP6348123B2 (ja) 2018-06-27
IL240108B (en) 2020-03-31
HRP20170198T1 (hr) 2017-04-07
SI2948160T1 (sl) 2017-02-28
IL240108A0 (en) 2015-09-24
HUE033162T2 (en) 2017-11-28
NZ710337A (en) 2019-04-26
EA030130B1 (ru) 2018-06-29
DK2948160T3 (en) 2017-02-20

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