MX359136B - Composiciones que contienen sulfato de condroitina, enzimas proteoliticas y compuestos sulfhidrilo para mejorar la biodisponibilidad de sulfato de condroitina. - Google Patents
Composiciones que contienen sulfato de condroitina, enzimas proteoliticas y compuestos sulfhidrilo para mejorar la biodisponibilidad de sulfato de condroitina.Info
- Publication number
- MX359136B MX359136B MX2015009544A MX2015009544A MX359136B MX 359136 B MX359136 B MX 359136B MX 2015009544 A MX2015009544 A MX 2015009544A MX 2015009544 A MX2015009544 A MX 2015009544A MX 359136 B MX359136 B MX 359136B
- Authority
- MX
- Mexico
- Prior art keywords
- chondroitin sulphate
- samples
- combinations
- bioavailability
- improving
- Prior art date
Links
- 229920001287 Chondroitin sulfate Polymers 0.000 title abstract 8
- 239000000203 mixture Substances 0.000 title abstract 3
- 125000003396 thiol group Chemical group [H]S* 0.000 title abstract 2
- 102000035195 Peptidases Human genes 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 title 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000008578 acute process Effects 0.000 abstract 1
- 230000006020 chronic inflammation Effects 0.000 abstract 1
- 230000002596 correlated effect Effects 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000031891 intestinal absorption Effects 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
- 239000002417 nutraceutical Substances 0.000 abstract 1
- 235000021436 nutraceutical agent Nutrition 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000002797 proteolythic effect Effects 0.000 abstract 1
- 230000036642 wellbeing Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Materials Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Botany (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a composiciones que comprenden sulfato de condroitina (CS), una o más enzimas o mezclas enzimáticas que tienen actividad proteolítica, y compuestos sulfhidrilo, para el tratamiento y prevención de osteoartrítis y procesos inflamatorios agudos y crónicos correlacionados, o como composiciones nutraceúticas para el mantenimiento del bienestar musculoesquelético en humanos y animales; la característica de dichas combinaciones es que incrementan la absorción intestinal de CS cuando se administran de manera oral; el efecto de dichas combinaciones se ejerce en una amplia gama de pesos moleculares de CS, incluyendo muestras de CS con pesos moleculares muy bajos que ya poseen mayor biodisponibilidad que la de muestras con un peso molecular mayor; el efecto se ejerce en muestras de CS de cualquier origen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000117A ITMI20130117A1 (it) | 2013-01-25 | 2013-01-25 | Composizioni comprendenti condroitin solfato, enzimi proteolitici e composti sulfidrilati capaci di migliorare la biodisponibilita' del condroitin solfato |
| PCT/EP2014/051308 WO2014114706A1 (en) | 2013-01-25 | 2014-01-23 | Compositions containing chondroitin sulphate, proteolytic enzymes and sulphydryl compounds for improving the bioavailability of chondroitin sulphate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015009544A MX2015009544A (es) | 2015-11-25 |
| MX359136B true MX359136B (es) | 2018-09-14 |
Family
ID=47749928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015009544A MX359136B (es) | 2013-01-25 | 2014-01-23 | Composiciones que contienen sulfato de condroitina, enzimas proteoliticas y compuestos sulfhidrilo para mejorar la biodisponibilidad de sulfato de condroitina. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20150366978A1 (es) |
| EP (1) | EP2948160B1 (es) |
| JP (1) | JP6348123B2 (es) |
| KR (1) | KR102235577B1 (es) |
| CN (1) | CN105101985B (es) |
| AU (1) | AU2014209961B2 (es) |
| BR (1) | BR112015017544B1 (es) |
| CA (1) | CA2899129C (es) |
| CY (1) | CY1118433T1 (es) |
| DK (1) | DK2948160T3 (es) |
| EA (1) | EA030130B1 (es) |
| ES (1) | ES2616017T3 (es) |
| GE (1) | GEP201706673B (es) |
| HR (1) | HRP20170198T1 (es) |
| HU (1) | HUE033162T2 (es) |
| IL (1) | IL240108B (es) |
| IT (1) | ITMI20130117A1 (es) |
| LT (1) | LT2948160T (es) |
| MX (1) | MX359136B (es) |
| NZ (1) | NZ710337A (es) |
| PH (1) | PH12015501474A1 (es) |
| PL (1) | PL2948160T3 (es) |
| PT (1) | PT2948160T (es) |
| SI (1) | SI2948160T1 (es) |
| UA (1) | UA114941C2 (es) |
| WO (1) | WO2014114706A1 (es) |
| ZA (1) | ZA201505322B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215176A (zh) * | 2016-08-22 | 2016-12-14 | 安徽瑞达健康产业投资有限公司 | 一种高效抗炎多酶组合物 |
| FR3071504B1 (fr) * | 2017-09-26 | 2021-01-15 | Oenotropic Innovation | Produit biologique pour ameliorer la stabilite proteique de boissons a base de mouts vegetaux |
| CN108741099A (zh) * | 2018-06-11 | 2018-11-06 | 广州尚天诚品生物科技有限公司 | 一种有助于关节舒适的营养组合物及其制备方法和应用 |
| KR102231289B1 (ko) * | 2018-12-26 | 2021-03-23 | (주)휴온스 | 고함량 콘드로이틴설페이트 약학 제제 및 이의 제조방법 |
| CN111744018A (zh) * | 2019-03-26 | 2020-10-09 | 北京福元医药股份有限公司 | 一种盐酸氨基葡萄糖药物制剂 |
| CN112741272B (zh) * | 2021-01-18 | 2023-02-28 | 黑龙江中医药大学 | 一种高含量纳豆激酶的纳豆冻干粉的发酵方法 |
| IT202100030935A1 (it) | 2021-12-09 | 2023-06-09 | Fidia Farm Spa | Compresse comprendenti condroitin solfato, glucosamina cloridrato e vitamina c per il trattamento di danni cartilaginei, tendinei, ossei |
| CN117859887A (zh) * | 2023-01-28 | 2024-04-12 | 浙江工商大学 | 一种具有pH响应的智能型双相脂质体水凝胶体系及其制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5084482A (en) * | 1990-04-10 | 1992-01-28 | The Lithox Corporation | Methods for inhibiting inflammatory ischemic, thrombotic and cholesterolemic disease response with methionine compounds |
| US5679344A (en) | 1995-07-20 | 1997-10-21 | Susan K. Williams | Glucosamine composition and method |
| US5840715A (en) * | 1995-12-11 | 1998-11-24 | Inholtra Investment Holdings & Trading, N.V. | Dietary regimen of nutritional supplements for relief of symptoms of arthritis |
| US5888514A (en) | 1997-05-23 | 1999-03-30 | Weisman; Bernard | Natural composition for treating bone or joint inflammation |
| NZ533078A (en) * | 2000-07-31 | 2006-11-30 | Dermal Res Lab Inc | Preventing or treating diseases associated with allergies, autoimmunity and adhesion, metastatic and coronary cascades using complex carbohydrates, in particular hyaluronic acid |
| ITMI20012200A1 (it) * | 2001-10-22 | 2003-04-22 | Ibsa Inst Biochimique Sa | Processo per la preparazione di condroitin solfati dal polisaccaride k4 e prodotti ottenuti |
| US20040241256A1 (en) * | 2002-12-05 | 2004-12-02 | Seymour Ehrenpreis | Medicinal compositions & therapeutic methods |
| JP4466012B2 (ja) * | 2003-08-26 | 2010-05-26 | 日油株式会社 | 腸溶性製剤およびその製造方法 |
| JP2006083151A (ja) * | 2004-09-16 | 2006-03-30 | Oriza Yuka Kk | 骨粗鬆症予防、改善用組成物 |
| JP5462430B2 (ja) * | 2006-01-19 | 2014-04-02 | オリザ油化株式会社 | 抗炎症剤及び鎮痛剤 |
| WO2008021987A2 (en) * | 2006-08-10 | 2008-02-21 | Jon Barron | Proteolytic enzyme formulations |
| AT504159A1 (de) * | 2006-08-16 | 2008-03-15 | Marlyn Nutraceuticals Inc | Verwendung von proteasen |
| US20090110674A1 (en) * | 2007-10-24 | 2009-04-30 | Loizou Nicos C | Health supplement |
| RU2381021C2 (ru) * | 2007-11-12 | 2010-02-10 | Леонид Леонидович Клопотенко | Зубная паста, содержащая липосомы |
| AU2012252415B2 (en) | 2011-05-12 | 2016-11-24 | Gnosis S.P.A. | "Biotechnological sulphated chondroitin sulphate at position 4 or 6 on the same polysaccharide chain, and process for the preparation thereof" |
| PL2710043T3 (pl) | 2011-05-20 | 2016-11-30 | Podobny do rekiniego siarczan chondroityny oraz sposób jego wytwarzania | |
| ITMI20120880A1 (it) | 2012-05-22 | 2013-11-23 | Gnosis Spa | Condroitin 6-solfato biotecnologico a basso peso molecolare dotato di attivita' antiinfiammatoria e antiartritica e suo uso nel trattamento e nella prevenzione dell'osteoartrite |
-
2013
- 2013-01-25 IT IT000117A patent/ITMI20130117A1/it unknown
-
2014
- 2014-01-23 HU HUE14704531A patent/HUE033162T2/en unknown
- 2014-01-23 LT LTEP14704531.4T patent/LT2948160T/lt unknown
- 2014-01-23 KR KR1020157020125A patent/KR102235577B1/ko active Active
- 2014-01-23 HR HRP20170198TT patent/HRP20170198T1/hr unknown
- 2014-01-23 CN CN201480005773.7A patent/CN105101985B/zh active Active
- 2014-01-23 BR BR112015017544-9A patent/BR112015017544B1/pt active IP Right Grant
- 2014-01-23 CA CA2899129A patent/CA2899129C/en active Active
- 2014-01-23 US US14/763,120 patent/US20150366978A1/en not_active Abandoned
- 2014-01-23 DK DK14704531.4T patent/DK2948160T3/en active
- 2014-01-23 PL PL14704531T patent/PL2948160T3/pl unknown
- 2014-01-23 EA EA201591216A patent/EA030130B1/ru not_active IP Right Cessation
- 2014-01-23 WO PCT/EP2014/051308 patent/WO2014114706A1/en not_active Ceased
- 2014-01-23 NZ NZ710337A patent/NZ710337A/en unknown
- 2014-01-23 PT PT147045314T patent/PT2948160T/pt unknown
- 2014-01-23 EP EP14704531.4A patent/EP2948160B1/en active Active
- 2014-01-23 JP JP2015554141A patent/JP6348123B2/ja active Active
- 2014-01-23 MX MX2015009544A patent/MX359136B/es active IP Right Grant
- 2014-01-23 ES ES14704531.4T patent/ES2616017T3/es active Active
- 2014-01-23 AU AU2014209961A patent/AU2014209961B2/en active Active
- 2014-01-23 UA UAA201507424A patent/UA114941C2/uk unknown
- 2014-01-23 SI SI201430127A patent/SI2948160T1/sl unknown
- 2014-01-23 GE GEAP201413894A patent/GEP201706673B/en unknown
-
2015
- 2015-06-26 PH PH12015501474A patent/PH12015501474A1/en unknown
- 2015-07-23 ZA ZA2015/05322A patent/ZA201505322B/en unknown
- 2015-07-23 IL IL240108A patent/IL240108B/en active IP Right Grant
-
2017
- 2017-01-17 CY CY20171100058T patent/CY1118433T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |