EA201590285A1 - Способ и система для ориентирования и/или сортировки микрофлюидных частиц - Google Patents

Способ и система для ориентирования и/или сортировки микрофлюидных частиц

Info

Publication number
EA201590285A1
EA201590285A1 EA201590285A EA201590285A EA201590285A1 EA 201590285 A1 EA201590285 A1 EA 201590285A1 EA 201590285 A EA201590285 A EA 201590285A EA 201590285 A EA201590285 A EA 201590285A EA 201590285 A1 EA201590285 A1 EA 201590285A1
Authority
EA
Eurasian Patent Office
Prior art keywords
particles
radiation pressure
orientation
sorting
microfluidic system
Prior art date
Application number
EA201590285A
Other languages
English (en)
Other versions
EA030193B1 (ru
Inventor
Мириам Кэтер Симпсон
Чарлз Алан Роди
Original Assignee
Инджендер Текнолоджиз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Инджендер Текнолоджиз Лимитед filed Critical Инджендер Текнолоджиз Лимитед
Publication of EA201590285A1 publication Critical patent/EA201590285A1/ru
Publication of EA030193B1 publication Critical patent/EA030193B1/ru

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1425—Optical investigation techniques, e.g. flow cytometry using an analyser being characterised by its control arrangement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1425—Optical investigation techniques, e.g. flow cytometry using an analyser being characterised by its control arrangement
    • G01N15/1427—Optical investigation techniques, e.g. flow cytometry using an analyser being characterised by its control arrangement with the synchronisation of components, a time gate for operation of components, or suppression of particle coincidences
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N2015/0288—Sorting the particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Fluid Mechanics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Система для ориентирования частиц в микрофлюидной системе содержит один или более источников давления излучения, выполненных с возможностью воздействия давлением излучения на частицы для обеспечения установления ориентации частиц в жидкости. Система для сортировки частиц в микрофлюидной системе включает блок обнаружения, предназначенный для обнаружения по меньшей мере одного отличия или дискриминации между частицами в потоке жидкости на блоке обнаружения, и один или более источников давления излучения, рядом с которыми последовательно проходят частицы, и устройство управления, выполненное с возможностью изменения направления энергии излучения для обеспечения изменения в направлении перемещения отобранных частиц в потоке жидкости для сортировки частиц. Частицы могут быть биологическими частицами, такими как сперматозоиды. Давление излучения может быть оптическим давлением и может быть образовано из одного или более световодов, которые могут проходить через канал микрофлюидной системы.
EA201590285A 2012-07-27 2013-07-29 Способ и система для ориентирования и/или сортировки микрофлюидных частиц EA030193B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261676391P 2012-07-27 2012-07-27
PCT/NZ2013/000135 WO2014017929A1 (en) 2012-07-27 2013-07-29 Method and system for microfluidic particle orientation and/or sorting

Publications (2)

Publication Number Publication Date
EA201590285A1 true EA201590285A1 (ru) 2015-10-30
EA030193B1 EA030193B1 (ru) 2018-07-31

Family

ID=49997621

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590285A EA030193B1 (ru) 2012-07-27 2013-07-29 Способ и система для ориентирования и/или сортировки микрофлюидных частиц

Country Status (14)

Country Link
US (4) US9784663B2 (ru)
EP (2) EP3845885A1 (ru)
CN (1) CN104884934B (ru)
AU (1) AU2013293647B2 (ru)
BR (1) BR112015001844B1 (ru)
CA (2) CA3079158C (ru)
DK (1) DK2877832T3 (ru)
EA (1) EA030193B1 (ru)
ES (1) ES2842552T3 (ru)
IN (1) IN2015KN00498A (ru)
MX (1) MX359348B (ru)
NZ (1) NZ725649A (ru)
UA (1) UA116637C2 (ru)
WO (1) WO2014017929A1 (ru)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
EP2142279A2 (en) 2007-04-16 2010-01-13 The General Hospital Corporation d/b/a Massachusetts General Hospital Systems and methods for particle focusing in microchannels
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
US9784663B2 (en) 2012-07-27 2017-10-10 Engender Technologies Limited Method and system for microfluidic particle orientation and/or sorting
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
CN103499534B (zh) * 2013-07-25 2015-09-09 中国科学院苏州纳米技术与纳米仿生研究所 高灵敏太赫兹微流通道传感器及其制备方法
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
WO2015095085A2 (en) 2013-12-16 2015-06-25 Brubacher John Miles Microorganism evaluation system
EP3040750A1 (en) * 2014-12-29 2016-07-06 IMEC vzw Device and method for performing lens-free imaging
US9739751B2 (en) * 2015-02-05 2017-08-22 International Business Machines Corporation Devices for trapping and controlling microparticles with radiation
JP2018509615A (ja) 2015-02-19 2018-04-05 プレミアム ジェネティクス （ユーケー） リミテッド 走査型赤外線測定システム
WO2017180325A1 (en) * 2016-04-15 2017-10-19 Becton, Dickinson And Company Enclosed droplet sorter and methods of using the same
GB201608549D0 (en) * 2016-05-16 2016-06-29 Dublin Inst Of Technology A multianalyte photonic biosensor system
IT201600104612A1 (it) * 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa Sistema microfluidico e metodo per l'isolamento di particelle
WO2018073767A1 (en) * 2016-10-18 2018-04-26 Menarini Silicon Biosystems S.P.A. Microfluidic device, microfluidic system and method for the isolation of particles
IT201600104645A1 (it) * 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa Dispositivo microfluidico e metodo per l'isolamento di particelle
CN106885807B (zh) * 2017-02-21 2020-04-24 澳门大学 基于微流控技术的大规模活生物体筛选系统
CN107603940B (zh) * 2017-09-07 2020-10-27 中国科学技术大学 利用楔形光镊光场分选微粒的方法
IT201700105948A1 (it) * 2017-09-21 2019-03-21 Menarini Silicon Biosystems Spa Metodo e sistema microfluidico per il recupero di particelle
EP3499215B1 (en) * 2017-12-15 2023-06-28 ams AG Particle density sensor using evanescent wave of waveguide
CA3098299A1 (en) * 2018-04-25 2020-01-16 Engender Technologies Ltd. Systems, devices and methods associated with microfluidic systems
BR112020023607A2 (pt) * 2018-05-23 2021-02-17 Abs Global, Inc. sistemas e métodos para focalização de partículas em microcanais
CN109880744B (zh) * 2019-03-22 2022-07-29 华南师范大学 光流控细胞分选芯片及其分选细胞的方法
EP3955735B1 (en) 2019-04-18 2024-05-22 ABS Global, Inc. System and process for continuous addition of cryoprotectant
CN110468027B (zh) * 2019-09-07 2022-04-19 桂林电子科技大学 一种基于同轴双波导光纤的细胞分选微流芯片
CN111172010B (zh) * 2019-09-07 2022-05-13 桂林电子科技大学 一种基于三芯光纤的细胞分选微流芯片
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
WO2022139597A1 (en) * 2020-12-23 2022-06-30 Engender Technologies Limited Particle classification and sorting systems and methods
US11921026B2 (en) * 2021-04-16 2024-03-05 Cytonome/St, Llc Method and apparatus for an anti-sorting flow cytometer
CN113834764A (zh) * 2021-08-26 2021-12-24 桂林电子科技大学 一种用于微粒定向弹射的光纤来福枪系统及控制方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07104191A (ja) * 1991-09-02 1995-04-21 Jasco Corp 細胞等の微粒子の姿勢位置制御装置
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US20030007894A1 (en) 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
AU2003216175A1 (en) * 2002-02-04 2003-09-02 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
US6976590B2 (en) * 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
US6808075B2 (en) * 2002-04-17 2004-10-26 Cytonome, Inc. Method and apparatus for sorting particles
US7118676B2 (en) * 2003-09-04 2006-10-10 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
AU2003280704A1 (en) * 2002-11-01 2004-05-25 Techno Network Shikoku Co., Ltd. Method for sorting and recovering fine particle and apparatus for recovery
DK2305171T3 (da) * 2003-03-28 2022-03-21 Inguran Llc Apparat og fremgangsmåder til tilvejebringelse af kønssorteret dyresæd
US20050067337A1 (en) * 2003-09-30 2005-03-31 Hart Sean J. Laser optical separator and method for separating colloidal suspensions
US7676122B2 (en) 2006-12-11 2010-03-09 Jiahua James Dou Apparatus, system and method for particle manipulation using waveguides
EP2156178B1 (en) * 2007-04-02 2011-12-21 Acoustic Cytometry Systems, Inc. Methods for enhanced analysis of acoustic field focused cells and particles
EP2142279A2 (en) * 2007-04-16 2010-01-13 The General Hospital Corporation d/b/a Massachusetts General Hospital Systems and methods for particle focusing in microchannels
US8691164B2 (en) 2007-04-20 2014-04-08 Celula, Inc. Cell sorting system and methods
US8120770B2 (en) * 2007-09-10 2012-02-21 The Penn State Research Foundation Three-dimensional (3D) hydrodynamic focusing using a microfluidic device
US8266951B2 (en) * 2007-12-19 2012-09-18 Los Alamos National Security, Llc Particle analysis in an acoustic cytometer
EP2335057B1 (en) * 2008-09-08 2018-01-03 Technological Resources PTY. Limited Dual energy x-ray transmission method for analysing ores
US8162149B1 (en) * 2009-01-21 2012-04-24 Sandia Corporation Particle sorter comprising a fluid displacer in a closed-loop fluid circuit
US9134221B2 (en) * 2009-03-10 2015-09-15 The Regents Of The University Of California Fluidic flow cytometry devices and particle sensing based on signal-encoding
CN103331185A (zh) * 2009-07-07 2013-10-02 索尼公司 微流体装置
US8496889B2 (en) * 2010-03-23 2013-07-30 California Institute Of Technology Microfluidic device for separating and sorting particles in a fluid medium
US20120225475A1 (en) * 2010-11-16 2012-09-06 1087 Systems, Inc. Cytometry system with quantum cascade laser source, acoustic detector, and micro-fluidic cell handling system configured for inspection of individual cells
EP2661614A2 (en) * 2011-01-03 2013-11-13 Cytonome/ST, LLC Method and apparatus for monitoring and optimizing particle sorting
US9784663B2 (en) * 2012-07-27 2017-10-10 Engender Technologies Limited Method and system for microfluidic particle orientation and/or sorting
US9757726B2 (en) * 2013-03-14 2017-09-12 Inguran, Llc System for high throughput sperm sorting
FR3024738B1 (fr) * 2014-08-11 2018-06-15 Genes Diffusion Dispostif et procede de selection de cellules eucaryotes dans un canal de transport par alteration des cellules eucaryotes au moyen d'un rayonnemement electromagnetique

Also Published As

Publication number Publication date
AU2013293647A1 (en) 2015-03-12
EP3845885A1 (en) 2021-07-07
EA030193B1 (ru) 2018-07-31
US9784663B2 (en) 2017-10-10
MX2015001251A (es) 2015-08-14
CN104884934A (zh) 2015-09-02
US20170370822A1 (en) 2017-12-28
MX359348B (es) 2018-09-26
CN104884934B (zh) 2018-11-02
US11480516B2 (en) 2022-10-25
AU2013293647B2 (en) 2017-08-31
BR112015001844B1 (pt) 2021-03-02
CA3079158C (en) 2023-03-07
WO2014017929A1 (en) 2014-01-30
CA3079158A1 (en) 2014-01-30
CA2894459A1 (en) 2014-01-30
US10393644B2 (en) 2019-08-27
NZ725649A (en) 2018-05-25
DK2877832T3 (da) 2021-01-18
IN2015KN00498A (ru) 2015-07-17
ES2842552T3 (es) 2021-07-14
BR112015001844A2 (pt) 2018-05-29
EP2877832A1 (en) 2015-06-03
UA116637C2 (uk) 2018-04-25
EP2877832A4 (en) 2016-04-20
EP2877832B1 (en) 2020-10-28
US10712255B2 (en) 2020-07-14
US20200408666A1 (en) 2020-12-31
US20190331588A1 (en) 2019-10-31
US20150198517A1 (en) 2015-07-16
CA2894459C (en) 2020-07-07

Similar Documents

Publication Publication Date Title
EA201590285A1 (ru) Способ и система для ориентирования и/или сортировки микрофлюидных частиц
AR085246A1 (es) Metodos, sistemas y aparato para realizar citometrias de flujo
BR112015007180A2 (pt) sistemas e métodos para monitoramento em tempo real de formação de hidrato de gás
CL2012002890A1 (es) Analizador de muestra microfluidica, que comprende un alojamiento, una abertura en el alojamiento, un sistema de control de presion posicionado dentro del alojamiento, un sistema optico; metodopara analizar una muestra; y un dispositivo.
WO2015063552A3 (en) Microfluidic system and method with focused energy apparatus
MX2020001500A (es) Un sistema de deteccion microfluidico y un cartucho microfluidico.
CL2018000570A1 (es) Análisis de gas en el aliento
BR112015007826A2 (pt) sistemas e métodos para monitoramento em tempo real e administração de fluidos de manutenção de poço
BR112015023712A2 (pt) sistema óptico para um citômetro de fluxo
MX362080B (es) Sistemas y metodos para analizar sustancias microbiologicas.
MX2017003454A (es) Sistemas y metodos para la integracion de la recoleccion de microfluido lagrimal y el analisis por flujo lateral de analitos de interes.
WO2013186672A3 (en) Optical detection system for liquid samples
MX341261B (es) Sistemas y metodos para monitorear procesos quimicos.
MX368929B (es) Sistemas y metodos para mediciones en tiempo real de contenido de gas en fluidos de perforacion.
AR091675A1 (es) Sistema integrado de deteccion temprana de hidrocarburos en un medio acuoso
WO2012138882A3 (en) Micro-fluidic system using micro-apertures for high throughput detection of cells
UA111729C2 (uk) Пристрій для відокремлення твердих речовин від рідини і спосіб обробки біомаси, який включає відокремлення твердих речовин від рідини
SA515360097B1 (ar) أنظمة وطرق لرصد عمليات فصل النفط/الغاز
WO2013025682A3 (en) Sample viscosity and flow control for heavy samples, and x-ray analysis applications thereof
BR112018069889A2 (pt) microfluídicos para detecção de analito com base na luz para propriedades de conversão de calor de nanopartículas metálicas
GB201113992D0 (en) Device
WO2012054641A3 (en) Hydrodynamic particle separation and detection systems and methods
GB2549819A (en) Method and device for detection of whole organism bacteria
CL2018000384A1 (es) Método y dispositivo para determinar una concentración de sustancias o una sustancia en un medio líquido.
WO2014102791A3 (en) Device, system and method for in-vivo detection of blood in gastrointestinal fluids

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM