DK2877832T3 - System til mikrofluidisk orientering og sortering af partikler - Google Patents

System til mikrofluidisk orientering og sortering af partikler Download PDF

Info

Publication number
DK2877832T3
DK2877832T3 DK13823614.6T DK13823614T DK2877832T3 DK 2877832 T3 DK2877832 T3 DK 2877832T3 DK 13823614 T DK13823614 T DK 13823614T DK 2877832 T3 DK2877832 T3 DK 2877832T3
Authority
DK
Denmark
Prior art keywords
microfluid
orientation
sorting system
particle sorting
particle
Prior art date
Application number
DK13823614.6T
Other languages
English (en)
Inventor
Miriam Cather Simpson
Charles Alan Rohde
Original Assignee
Engender Tech Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Engender Tech Limited filed Critical Engender Tech Limited
Application granted granted Critical
Publication of DK2877832T3 publication Critical patent/DK2877832T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1425—Optical investigation techniques, e.g. flow cytometry using an analyser being characterised by its control arrangement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1425—Optical investigation techniques, e.g. flow cytometry using an analyser being characterised by its control arrangement
    • G01N15/1427—Optical investigation techniques, e.g. flow cytometry using an analyser being characterised by its control arrangement with the synchronisation of components, a time gate for operation of components, or suppression of particle coincidences
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N2015/0288—Sorting the particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK13823614.6T 2012-07-27 2013-07-29 System til mikrofluidisk orientering og sortering af partikler DK2877832T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261676391P 2012-07-27 2012-07-27
PCT/NZ2013/000135 WO2014017929A1 (en) 2012-07-27 2013-07-29 Method and system for microfluidic particle orientation and/or sorting

Publications (1)

Publication Number Publication Date
DK2877832T3 true DK2877832T3 (da) 2021-01-18

Family

ID=49997621

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13823614.6T DK2877832T3 (da) 2012-07-27 2013-07-29 System til mikrofluidisk orientering og sortering af partikler

Country Status (14)

Country Link
US (4) US9784663B2 (da)
EP (2) EP3845885A1 (da)
CN (1) CN104884934B (da)
AU (1) AU2013293647B2 (da)
BR (1) BR112015001844B1 (da)
CA (2) CA3079158C (da)
DK (1) DK2877832T3 (da)
EA (1) EA030193B1 (da)
ES (1) ES2842552T3 (da)
IN (1) IN2015KN00498A (da)
MX (1) MX359348B (da)
NZ (1) NZ725649A (da)
UA (1) UA116637C2 (da)
WO (1) WO2014017929A1 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
CN103630470B (zh) 2007-04-16 2016-03-16 通用医疗公司以马萨诸塞州通用医疗公司名义经营 使粒子在微通道中聚集的系统和方法
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
DK2877832T3 (da) * 2012-07-27 2021-01-18 Engender Tech Limited System til mikrofluidisk orientering og sortering af partikler
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
CN103499534B (zh) * 2013-07-25 2015-09-09 中国科学院苏州纳米技术与纳米仿生研究所 高灵敏太赫兹微流通道传感器及其制备方法
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
US10481075B2 (en) * 2013-12-16 2019-11-19 Sobru Solutions, Inc. Microorganism evaluation system
EP3040750A1 (en) * 2014-12-29 2016-07-06 IMEC vzw Device and method for performing lens-free imaging
US9739751B2 (en) * 2015-02-05 2017-08-22 International Business Machines Corporation Devices for trapping and controlling microparticles with radiation
EP4137798A1 (en) 2015-02-19 2023-02-22 1087 Systems, Inc. Scanning infrared measurement system
AU2017249049A1 (en) * 2016-04-15 2018-10-25 Becton, Dickinson And Company Enclosed droplet sorter and methods of using the same
GB201608549D0 (en) * 2016-05-16 2016-06-29 Dublin Inst Of Technology A multianalyte photonic biosensor system
JP7029461B2 (ja) * 2016-10-18 2022-03-03 メナリーニ・シリコン・バイオシステムズ・ソシエタ・ペル・アチオニ 粒子を隔離するためのマイクロ流体装置とマイクロ流体システムと方法
IT201600104612A1 (it) * 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa Sistema microfluidico e metodo per l'isolamento di particelle
IT201600104645A1 (it) * 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa Dispositivo microfluidico e metodo per l'isolamento di particelle
CN106885807B (zh) * 2017-02-21 2020-04-24 澳门大学 基于微流控技术的大规模活生物体筛选系统
CN107603940B (zh) * 2017-09-07 2020-10-27 中国科学技术大学 利用楔形光镊光场分选微粒的方法
IT201700105948A1 (it) * 2017-09-21 2019-03-21 Menarini Silicon Biosystems Spa Metodo e sistema microfluidico per il recupero di particelle
EP3499215B1 (en) * 2017-12-15 2023-06-28 ams AG Particle density sensor using evanescent wave of waveguide
WO2020013903A2 (en) * 2018-04-25 2020-01-16 Engender Technologies Ltd. Systems, devices and methods associated with microfluidic systems
WO2019226790A1 (en) 2018-05-23 2019-11-28 Abs Global, Inc. Systems and methods for particle focusing in microchannels
CN109880744B (zh) * 2019-03-22 2022-07-29 华南师范大学 光流控细胞分选芯片及其分选细胞的方法
WO2020215011A1 (en) 2019-04-18 2020-10-22 Abs Global, Inc. System and process for continuous addition of cryoprotectant
CN110468027B (zh) * 2019-09-07 2022-04-19 桂林电子科技大学 一种基于同轴双波导光纤的细胞分选微流芯片
CN111172010B (zh) * 2019-09-07 2022-05-13 桂林电子科技大学 一种基于三芯光纤的细胞分选微流芯片
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
EP4232601A4 (en) 2020-10-21 2024-10-09 ABS Global, Inc. METHODS AND SYSTEMS FOR PROCESSING GENETIC SAMPLES TO DETERMINE IDENTITY OR DETECT CONTAMINATION
EP4248190A4 (en) 2020-11-23 2024-12-25 ABS Global, Inc. MODULAR FLOW CYTOMETRY SYSTEMS AND METHODS FOR PROCESSING SAMPLES
EP4267938A4 (en) * 2020-12-23 2024-06-05 Engender Technologies Limited PARTICLE CLASSIFICATION AND SORTING SYSTEMS AND METHODS
US11921026B2 (en) 2021-04-16 2024-03-05 Cytonome/St, Llc Method and apparatus for an anti-sorting flow cytometer
CN113834764A (zh) * 2021-08-26 2021-12-24 桂林电子科技大学 一种用于微粒定向弹射的光纤来福枪系统及控制方法
CN118417180B (zh) * 2024-07-04 2024-10-25 中国农业科学院农业信息研究所 种子品质分级装置及种子品质检测分级系统

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07104191A (ja) * 1991-09-02 1995-04-21 Jasco Corp 細胞等の微粒子の姿勢位置制御装置
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US20030007894A1 (en) * 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
WO2003066191A1 (en) * 2002-02-04 2003-08-14 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
US6976590B2 (en) * 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
US6808075B2 (en) * 2002-04-17 2004-10-26 Cytonome, Inc. Method and apparatus for sorting particles
US7118676B2 (en) * 2003-09-04 2006-10-10 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
AU2003280704A1 (en) * 2002-11-01 2004-05-25 Techno Network Shikoku Co., Ltd. Method for sorting and recovering fine particle and apparatus for recovery
CA2518882C (en) * 2003-03-28 2017-05-09 Monsanto Technology Llc Apparatus, methods and processes for sorting particles and for providing sex-sorted animal sperm
US20050067337A1 (en) * 2003-09-30 2005-03-31 Hart Sean J. Laser optical separator and method for separating colloidal suspensions
US7676122B2 (en) 2006-12-11 2010-03-09 Jiahua James Dou Apparatus, system and method for particle manipulation using waveguides
ATE538377T1 (de) * 2007-04-02 2012-01-15 Acoustic Cytometry Systems Inc Verfahren zur verbesserten analyse von in einem akustischen feld fokussierten zellen und partikeln
CN103630470B (zh) * 2007-04-16 2016-03-16 通用医疗公司以马萨诸塞州通用医疗公司名义经营 使粒子在微通道中聚集的系统和方法
US8691164B2 (en) * 2007-04-20 2014-04-08 Celula, Inc. Cell sorting system and methods
US8120770B2 (en) * 2007-09-10 2012-02-21 The Penn State Research Foundation Three-dimensional (3D) hydrodynamic focusing using a microfluidic device
US8266950B2 (en) * 2007-12-19 2012-09-18 Los Alamos National Security, LLP Particle analysis in an acoustic cytometer
EP2335057B1 (en) * 2008-09-08 2018-01-03 Technological Resources PTY. Limited Dual energy x-ray transmission method for analysing ores
US8162149B1 (en) * 2009-01-21 2012-04-24 Sandia Corporation Particle sorter comprising a fluid displacer in a closed-loop fluid circuit
US9134221B2 (en) * 2009-03-10 2015-09-15 The Regents Of The University Of California Fluidic flow cytometry devices and particle sensing based on signal-encoding
CN103331185A (zh) * 2009-07-07 2013-10-02 索尼公司 微流体装置
US8496889B2 (en) * 2010-03-23 2013-07-30 California Institute Of Technology Microfluidic device for separating and sorting particles in a fluid medium
US20120225475A1 (en) * 2010-11-16 2012-09-06 1087 Systems, Inc. Cytometry system with quantum cascade laser source, acoustic detector, and micro-fluidic cell handling system configured for inspection of individual cells
WO2012094325A2 (en) * 2011-01-03 2012-07-12 Cytonome/St. Llc Method and apparatus for monitoring and optimizing particle sorting
DK2877832T3 (da) * 2012-07-27 2021-01-18 Engender Tech Limited System til mikrofluidisk orientering og sortering af partikler
US9757726B2 (en) * 2013-03-14 2017-09-12 Inguran, Llc System for high throughput sperm sorting
FR3024738B1 (fr) * 2014-08-11 2018-06-15 Genes Diffusion Dispostif et procede de selection de cellules eucaryotes dans un canal de transport par alteration des cellules eucaryotes au moyen d'un rayonnemement electromagnetique

Also Published As

Publication number Publication date
US10712255B2 (en) 2020-07-14
AU2013293647B2 (en) 2017-08-31
IN2015KN00498A (da) 2015-07-17
BR112015001844B1 (pt) 2021-03-02
US20190331588A1 (en) 2019-10-31
US9784663B2 (en) 2017-10-10
CA2894459C (en) 2020-07-07
MX359348B (es) 2018-09-26
CA3079158A1 (en) 2014-01-30
ES2842552T3 (es) 2021-07-14
UA116637C2 (uk) 2018-04-25
MX2015001251A (es) 2015-08-14
CA3079158C (en) 2023-03-07
EA201590285A1 (ru) 2015-10-30
NZ725649A (en) 2018-05-25
CA2894459A1 (en) 2014-01-30
EP2877832A1 (en) 2015-06-03
US10393644B2 (en) 2019-08-27
EP2877832B1 (en) 2020-10-28
US20150198517A1 (en) 2015-07-16
BR112015001844A2 (pt) 2018-05-29
US20200408666A1 (en) 2020-12-31
US20170370822A1 (en) 2017-12-28
AU2013293647A1 (en) 2015-03-12
EP2877832A4 (en) 2016-04-20
CN104884934A (zh) 2015-09-02
EA030193B1 (ru) 2018-07-31
WO2014017929A1 (en) 2014-01-30
CN104884934B (zh) 2018-11-02
US11480516B2 (en) 2022-10-25
EP3845885A1 (en) 2021-07-07

Similar Documents

Publication Publication Date Title
DK2877832T3 (da) System til mikrofluidisk orientering og sortering af partikler
DK2914291T3 (da) Anti-komplement-c1s-antistoffer og anvendelser deraf
DK3459965T3 (da) Fremgangsmåder til forudsigelse af forfædrevirussekvenser og anvendelser deraf
IL239508B (en) Devices, systems and methods of capturing and displaying appearances
DK3199552T3 (da) Anti-ceacam5-antistoffer og anvendelser heraf
DK2855736T3 (da) Elektrolysator og energisystem
EP2809597A4 (en) SORTING SYSTEMS AND CORRESPONDING METHODS
DK2838917T3 (da) Fremgangsmåder og midler til frembringelse af heterodimere ig-lignende molekyler
GB201508155D0 (en) Compact dehumidifiers and associated systems and methods
BR112014031384A2 (pt) métodos e sistemas
IL282628A (en) Electromagnetic (em) probes, methods of using such em probes and systems which use such electromagnetic em probes
IL238227A0 (en) Anti-c16orf54 antibodies and methods of use thereof
DK2919875T3 (da) Fremgangsmåde til at styre påstigning, afstigning og fremføring af skinneløse køretøjer og system til anvendelse deraf
IL254416B (en) Anti-asic1 antibodies and their uses
DK3567099T3 (da) Nyrecellepopulationer og anvendelser deraf
ZA201405554B (en) Anti-big-endothelin-1 (big-et-1) antibodies and uses thereof
GB201308576D0 (en) Separation and analysis
BR112014019186A2 (pt) Sistemas e métodos para processamento de arquivo
SG11201501159UA (en) Assay methods and systems
GB201310214D0 (en) Separation and Analysis Systems and Methods
BR112016011365A2 (pt) sistema de triagem e empilhamento de ladrilhos
BR112015003691A2 (pt) métodos e sistema.
EP2926114A4 (en) FLUIDIC SYSTEM AND METHOD
DE112013003437T8 (de) Analysesystem und Analyseverfahren
DK2811295T3 (da) Separationsmiddel og fremgangsmåde til fremstilling af dette