MX359348B - Método y sistema para la orientación y/o clasificación de partículas micro fluídicas. - Google Patents

Método y sistema para la orientación y/o clasificación de partículas micro fluídicas.

Info

Publication number
MX359348B
MX359348B MX2015001251A MX2015001251A MX359348B MX 359348 B MX359348 B MX 359348B MX 2015001251 A MX2015001251 A MX 2015001251A MX 2015001251 A MX2015001251 A MX 2015001251A MX 359348 B MX359348 B MX 359348B
Authority
MX
Mexico
Prior art keywords
particles
sorting
radiation pressure
microfluidic system
radiation
Prior art date
Application number
MX2015001251A
Other languages
English (en)
Other versions
MX2015001251A (es
Inventor
Cather Simpson Miriam
Alan Rohde Charles
Original Assignee
Engender Tech Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Engender Tech Limited filed Critical Engender Tech Limited
Publication of MX2015001251A publication Critical patent/MX2015001251A/es
Publication of MX359348B publication Critical patent/MX359348B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1425—Optical investigation techniques, e.g. flow cytometry using an analyser being characterised by its control arrangement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1425—Optical investigation techniques, e.g. flow cytometry using an analyser being characterised by its control arrangement
    • G01N15/1427—Optical investigation techniques, e.g. flow cytometry using an analyser being characterised by its control arrangement with the synchronisation of components, a time gate for operation of components, or suppression of particle coincidences
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N2015/0288—Sorting the particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Un sistema para la orientación de partículas en un sistema microfluidico incluye una o más fuentes de presión de radiación dispuestas para exponer las partículas a presión de radiación que causan que las partículas adopten una orientación particular en el fluido. Un sistema para la clasificación de las partículas en un sistema microfluidico incluye una etapa de detección dispuesta para detectar al menos una diferencia o discriminar entre las partículas en el flujo de fluido más allá de la etapa de detección, y una o más fuentes de presión de radiación más allá de las cuales las partículas se mueven secuencialmente y un controlador dispuesto para intercambiar la energía de radiación para causar un cambio en la dirección de movimiento de las partículas seleccionadas en el flujo de fluido para clasificar las partículas. Las partículas pueden ser partículas biológicas tal como espermatozoides. La presión de radiación puede ser presión óptica y puede ser de una o más guías de onda que pueden extenderse a través de un canal del sistema microfluidico.
MX2015001251A 2012-07-27 2013-07-29 Método y sistema para la orientación y/o clasificación de partículas micro fluídicas. MX359348B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261676391P 2012-07-27 2012-07-27
PCT/NZ2013/000135 WO2014017929A1 (en) 2012-07-27 2013-07-29 Method and system for microfluidic particle orientation and/or sorting

Publications (2)

Publication Number Publication Date
MX2015001251A MX2015001251A (es) 2015-08-14
MX359348B true MX359348B (es) 2018-09-26

Family

ID=49997621

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015001251A MX359348B (es) 2012-07-27 2013-07-29 Método y sistema para la orientación y/o clasificación de partículas micro fluídicas.

Country Status (14)

Country Link
US (4) US9784663B2 (es)
EP (2) EP2877832B1 (es)
CN (1) CN104884934B (es)
AU (1) AU2013293647B2 (es)
BR (1) BR112015001844B1 (es)
CA (2) CA2894459C (es)
DK (1) DK2877832T3 (es)
EA (1) EA030193B1 (es)
ES (1) ES2842552T3 (es)
IN (1) IN2015KN00498A (es)
MX (1) MX359348B (es)
NZ (1) NZ725649A (es)
UA (1) UA116637C2 (es)
WO (1) WO2014017929A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
EP2562531A3 (en) 2007-04-16 2013-03-06 The General Hospital Corporation d/b/a Massachusetts General Hospital Systems and methods for particle focusing in microchannels
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
AU2013293647B2 (en) * 2012-07-27 2017-08-31 Engender Technologies Limited Method and system for microfluidic particle orientation and/or sorting
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
CN103499534B (zh) * 2013-07-25 2015-09-09 中国科学院苏州纳米技术与纳米仿生研究所 高灵敏太赫兹微流通道传感器及其制备方法
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
US10481075B2 (en) 2013-12-16 2019-11-19 Sobru Solutions, Inc. Microorganism evaluation system
EP3040750A1 (en) * 2014-12-29 2016-07-06 IMEC vzw Device and method for performing lens-free imaging
US9739751B2 (en) * 2015-02-05 2017-08-22 International Business Machines Corporation Devices for trapping and controlling microparticles with radiation
HK1248809A1 (zh) 2015-02-19 2018-10-19 1087 Systems, Inc. 扫描红外线测量系统
KR20180137506A (ko) * 2016-04-15 2018-12-27 벡톤 디킨슨 앤드 컴퍼니 밀폐형 액적 분류기 및 이의 사용 방법
GB201608549D0 (en) * 2016-05-16 2016-06-29 Dublin Inst Of Technology A multianalyte photonic biosensor system
IT201600104645A1 (it) * 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa Dispositivo microfluidico e metodo per l'isolamento di particelle
IT201600104612A1 (it) * 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa Sistema microfluidico e metodo per l'isolamento di particelle
WO2018073767A1 (en) * 2016-10-18 2018-04-26 Menarini Silicon Biosystems S.P.A. Microfluidic device, microfluidic system and method for the isolation of particles
CN106885807B (zh) * 2017-02-21 2020-04-24 澳门大学 基于微流控技术的大规模活生物体筛选系统
CN107603940B (zh) * 2017-09-07 2020-10-27 中国科学技术大学 利用楔形光镊光场分选微粒的方法
IT201700105948A1 (it) * 2017-09-21 2019-03-21 Menarini Silicon Biosystems Spa Metodo e sistema microfluidico per il recupero di particelle
EP3499215B1 (en) 2017-12-15 2023-06-28 ams AG Particle density sensor using evanescent wave of waveguide
US20210237078A1 (en) * 2018-04-25 2021-08-05 Miriam Cather Simpson Systems, devices and methods associated with microfluidic systems
EP3796998A1 (en) * 2018-05-23 2021-03-31 ABS Global, Inc. Systems and methods for particle focusing in microchannels
CN113260848B (zh) 2018-12-21 2025-04-01 Abs全球公司 亚群识别的系统和方法
CN109880744B (zh) * 2019-03-22 2022-07-29 华南师范大学 光流控细胞分选芯片及其分选细胞的方法
WO2020215011A1 (en) 2019-04-18 2020-10-22 Abs Global, Inc. System and process for continuous addition of cryoprotectant
CN111172010B (zh) * 2019-09-07 2022-05-13 桂林电子科技大学 一种基于三芯光纤的细胞分选微流芯片
CN110468027B (zh) * 2019-09-07 2022-04-19 桂林电子科技大学 一种基于同轴双波导光纤的细胞分选微流芯片
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
EP4232601A4 (en) 2020-10-21 2024-10-09 ABS Global, Inc. METHODS AND SYSTEMS FOR PROCESSING GENETIC SAMPLES TO DETERMINE IDENTITY OR DETECT CONTAMINATION
EP4248190A4 (en) 2020-11-23 2024-12-25 ABS Global, Inc. MODULAR FLOW CYTOMETRY SYSTEMS AND METHODS FOR PROCESSING SAMPLES
CN116685675A (zh) * 2020-12-23 2023-09-01 产生技术有限公司 颗粒分类和分选系统及方法
US11921026B2 (en) * 2021-04-16 2024-03-05 Cytonome/St, Llc Method and apparatus for an anti-sorting flow cytometer
CN113834764A (zh) * 2021-08-26 2021-12-24 桂林电子科技大学 一种用于微粒定向弹射的光纤来福枪系统及控制方法
USD1118965S1 (en) 2021-11-12 2026-03-17 Abs Global, Inc. Flow cytometry device
CN118417180B (zh) * 2024-07-04 2024-10-25 中国农业科学院农业信息研究所 种子品质分级装置及种子品质检测分级系统

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07104191A (ja) * 1991-09-02 1995-04-21 Jasco Corp 細胞等の微粒子の姿勢位置制御装置
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US20030007894A1 (en) * 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
US6778724B2 (en) * 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
US7318902B2 (en) * 2002-02-04 2008-01-15 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
US6976590B2 (en) * 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
US6808075B2 (en) * 2002-04-17 2004-10-26 Cytonome, Inc. Method and apparatus for sorting particles
US7118676B2 (en) * 2003-09-04 2006-10-10 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
WO2004039501A1 (ja) 2002-11-01 2004-05-13 Techno Network Shikoku Co., Ltd. 微粒子の分別回収方法および回収装置
DE602004024874D1 (de) * 2003-03-28 2010-02-11 Inguran Llc Eschlechts-sortierten tierspermien
US20050067337A1 (en) * 2003-09-30 2005-03-31 Hart Sean J. Laser optical separator and method for separating colloidal suspensions
US7676122B2 (en) * 2006-12-11 2010-03-09 Jiahua James Dou Apparatus, system and method for particle manipulation using waveguides
ATE538377T1 (de) * 2007-04-02 2012-01-15 Acoustic Cytometry Systems Inc Verfahren zur verbesserten analyse von in einem akustischen feld fokussierten zellen und partikeln
EP2562531A3 (en) * 2007-04-16 2013-03-06 The General Hospital Corporation d/b/a Massachusetts General Hospital Systems and methods for particle focusing in microchannels
US8691164B2 (en) * 2007-04-20 2014-04-08 Celula, Inc. Cell sorting system and methods
US8120770B2 (en) * 2007-09-10 2012-02-21 The Penn State Research Foundation Three-dimensional (3D) hydrodynamic focusing using a microfluidic device
US8266950B2 (en) * 2007-12-19 2012-09-18 Los Alamos National Security, LLP Particle analysis in an acoustic cytometer
BRPI0918531B1 (pt) * 2008-09-08 2019-07-09 Technological Resources Pty Limited Método para analisar um material
US8162149B1 (en) * 2009-01-21 2012-04-24 Sandia Corporation Particle sorter comprising a fluid displacer in a closed-loop fluid circuit
WO2010104993A2 (en) * 2009-03-10 2010-09-16 The Regents Of The University Of California Fluidic flow cytometry devices and particle sensing based on signal-encoding
WO2011005776A1 (en) 2009-07-07 2011-01-13 Sony Corporation Microfluidic device
US8496889B2 (en) * 2010-03-23 2013-07-30 California Institute Of Technology Microfluidic device for separating and sorting particles in a fluid medium
US20120225475A1 (en) * 2010-11-16 2012-09-06 1087 Systems, Inc. Cytometry system with quantum cascade laser source, acoustic detector, and micro-fluidic cell handling system configured for inspection of individual cells
US10481069B2 (en) * 2011-01-03 2019-11-19 Cytonome/St, Llc Method and apparatus for monitoring and optimizing microfluidic particle sorting
AU2013293647B2 (en) * 2012-07-27 2017-08-31 Engender Technologies Limited Method and system for microfluidic particle orientation and/or sorting
US9757726B2 (en) * 2013-03-14 2017-09-12 Inguran, Llc System for high throughput sperm sorting
FR3024738B1 (fr) * 2014-08-11 2018-06-15 Genes Diffusion Dispostif et procede de selection de cellules eucaryotes dans un canal de transport par alteration des cellules eucaryotes au moyen d'un rayonnemement electromagnetique

Also Published As

Publication number Publication date
CN104884934A (zh) 2015-09-02
AU2013293647B2 (en) 2017-08-31
EP2877832B1 (en) 2020-10-28
US10712255B2 (en) 2020-07-14
CN104884934B (zh) 2018-11-02
CA3079158A1 (en) 2014-01-30
EA201590285A1 (ru) 2015-10-30
BR112015001844A2 (pt) 2018-05-29
US11480516B2 (en) 2022-10-25
EP2877832A4 (en) 2016-04-20
WO2014017929A1 (en) 2014-01-30
MX2015001251A (es) 2015-08-14
BR112015001844B1 (pt) 2021-03-02
EP3845885A1 (en) 2021-07-07
US20150198517A1 (en) 2015-07-16
US10393644B2 (en) 2019-08-27
ES2842552T3 (es) 2021-07-14
EA030193B1 (ru) 2018-07-31
CA2894459C (en) 2020-07-07
CA2894459A1 (en) 2014-01-30
US20200408666A1 (en) 2020-12-31
US9784663B2 (en) 2017-10-10
AU2013293647A1 (en) 2015-03-12
UA116637C2 (uk) 2018-04-25
CA3079158C (en) 2023-03-07
US20190331588A1 (en) 2019-10-31
NZ725649A (en) 2018-05-25
DK2877832T3 (da) 2021-01-18
IN2015KN00498A (es) 2015-07-17
EP2877832A1 (en) 2015-06-03
US20170370822A1 (en) 2017-12-28

Similar Documents

Publication Publication Date Title
MX359348B (es) Método y sistema para la orientación y/o clasificación de partículas micro fluídicas.
EP2796854A3 (en) Micro-lens systems for particle processing systems
WO2014062719A3 (en) Systems, apparatus, and methods for sorting particles
HK1250543A1 (zh) 用於多步骤细胞纯化和浓缩的方法和装置
BR112016029901A2 (pt) sistema e método para detecção de múltiplos recursos e análise de um pneu em rotação
GB2456671B (en) Fluid-borne particle detector
GB2568446A (en) Development of spinal cord on a microfludic chip
EP3430376B8 (en) Cell sorting using a high throughput fluorescence flow cytometer
WO2016172643A3 (en) Methods and systems for multiple taxonomic classification
EP3458857B8 (en) Systems and methods for automated single cell cytological classification in flow
CL2012002890A1 (es) Analizador de muestra microfluidica, que comprende un alojamiento, una abertura en el alojamiento, un sistema de control de presion posicionado dentro del alojamiento, un sistema optico; metodopara analizar una muestra; y un dispositivo.
WO2015103332A3 (en) Microbiome based systems, apparatus and methods for the exploration and production of hydrocarbons
EP2999420A4 (en) PNEUMATICALLY COUPLED FLUID CONTROL SYSTEM AND METHOD WITH AIR DETECTION AND REMOVAL
BR112017007654A2 (pt) sistemas e métodos para o imageamento de amostras de fluido
PH12017501967A1 (en) Maize plant dbn9936 and method for use in detecting nucleic acid sequence thereof
EP3314123A4 (en) Systems, apparatuses, and methods for cell sorting and flow cytometry
CL2014002925A1 (es) Metodo para determinar numero de fases en cascada de clasificacion de mineral, que comprende calcular probabilidad de determinar correctamente el contenido de una muestra mineral mediante sensor, calcular probabilidad de desviar correctamente la muestra mediante un desviador, calcular la utilidad de una cascada en base a las probabilidades, y determinar un numero de fases de clasificacion; sistema para clasificar mineral; metodo para separacion de material
CA2935963A1 (en) Improvements to aspirated sampling systems
WO2013190326A3 (en) Particle characterization
GB201221331D0 (en) Air sampling device
EP3126857A4 (en) Systems and methods for detecting and identifying arcing based on numerical analysis
WO2015124942A3 (en) Heterogeneous fluid sample characterization
WO2015048612A3 (en) Manifolds and methods of using them to control fluid flows
MX2015001961A (es) Metodos y sistemas para ensayos.
MX342645B (es) Aparatos, sistemas y metodos acondicionadores de sensor.

Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: ENGENDER TECHNOLOGIES LIMITED

FG Grant or registration