BR112018069889A2 - microfluídicos para detecção de analito com base na luz para propriedades de conversão de calor de nanopartículas metálicas - Google Patents

microfluídicos para detecção de analito com base na luz para propriedades de conversão de calor de nanopartículas metálicas

Info

Publication number
BR112018069889A2
BR112018069889A2 BR112018069889-0A BR112018069889A BR112018069889A2 BR 112018069889 A2 BR112018069889 A2 BR 112018069889A2 BR 112018069889 A BR112018069889 A BR 112018069889A BR 112018069889 A2 BR112018069889 A2 BR 112018069889A2
Authority
BR
Brazil
Prior art keywords
light
metal nanoparticles
flow path
heat conversion
analyte detection
Prior art date
Application number
BR112018069889-0A
Other languages
English (en)
Inventor
Parracino Mariantonietta
María Abad Pastor José
Puertas Lorente Sara
Grazu Bonavia Valeria
Martínez De La Fuente Jesús
Luisa Do Vale Fonseca Claro Ana
Original Assignee
Nannoimmunotech, S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nannoimmunotech, S.L. filed Critical Nannoimmunotech, S.L.
Publication of BR112018069889A2 publication Critical patent/BR112018069889A2/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/171—Systems in which incident light is modified in accordance with the properties of the material investigated with calorimetric detection, e.g. with thermal lens detection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/148—Specific details about calibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56916—Enterobacteria, e.g. shigella, salmonella, klebsiella, serratia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56922—Campylobacter

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Radiation Pyrometers (AREA)

Abstract

a presente invenção refere-se ao uso in vitro de um kit ou dispositivo compreendendo um microchip que compreende um substrato, em que o dito substrato compreende pelo menos um canal no substrato, o canal compreendendo uma entrada, uma saída, e um caminho de fluxo que conecta a entrada e a saída, em que a entrada e a saída definem em conjunto um plano médio; e uma porção do caminho de fluxo se desloca transversalmente através do plano médio , em que a porção do caminho de fluxo que se desloca transversalmente através do plano médio inclui um local de reconhecimento ou área sensora para detectar um analito alvo; para a detecção de um analito como resultado do calor gerado pelas nanopartículas metálicas quando elas são irradiadas com uma fonte externa de luz.
BR112018069889-0A 2016-03-28 2017-03-28 microfluídicos para detecção de analito com base na luz para propriedades de conversão de calor de nanopartículas metálicas BR112018069889A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16382137 2016-03-28
EP16382137.4 2016-03-28
PCT/EP2017/057346 WO2017167769A1 (en) 2016-03-28 2017-03-28 Microfluidics for analyte detection based on the light to heat conversion properties of metal nanoparticles

Publications (1)

Publication Number Publication Date
BR112018069889A2 true BR112018069889A2 (pt) 2019-04-30

Family

ID=55752237

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018069889-0A BR112018069889A2 (pt) 2016-03-28 2017-03-28 microfluídicos para detecção de analito com base na luz para propriedades de conversão de calor de nanopartículas metálicas

Country Status (7)

Country Link
US (1) US20190118174A1 (pt)
EP (1) EP3436193A1 (pt)
JP (1) JP2019515310A (pt)
CN (1) CN109475861A (pt)
BR (1) BR112018069889A2 (pt)
RU (1) RU2018137413A (pt)
WO (1) WO2017167769A1 (pt)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
WO2020021785A1 (ja) * 2018-07-25 2020-01-30 コニカミノルタ株式会社 ガス検出装置、ガス検出方法、表示制御方法、およびプログラム
KR102346758B1 (ko) * 2019-12-03 2021-12-31 서강대학교산학협력단 금 나노입자 합성을 위한 미세 액적 기반 미세유체칩 및 이의 용도
CN111545136B (zh) * 2020-04-05 2021-02-19 北京化工大学 一种高效光热转化的自悬浮聚合物气凝胶的制备方法及其应用
CN113856778A (zh) * 2021-11-03 2021-12-31 清华大学 一种选择性检测微生物的微流控芯片、装置和方法
CN114280049B (zh) * 2021-12-28 2024-01-05 江南大学 检测过敏原蛋白的比色-光热双模式试纸条及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020094580A1 (en) * 2001-01-16 2002-07-18 Jorgenson James W. Photothermal absorbance detection apparatus and method of using same
KR101556457B1 (ko) * 2003-09-11 2015-10-01 테라노스, 인코포레이티드 피분석물의 모니터링 및 약물 전달을 위한 의료 기기
EP2261650A3 (en) * 2004-09-15 2011-07-06 IntegenX Inc. Microfluidic devices
EP2126039A4 (en) * 2007-01-23 2011-03-16 Yeda Res & Dev MICROFLUIDIC DEVICES AND METHODS OF MAKING AND USING THE SAME
FR2960453B1 (fr) * 2010-05-28 2017-08-25 Centre Nat De La Rech Scient (Cnrs) Procede de fabrication d'une puce microfluidique, puce et plaque associees
ES2397909B1 (es) * 2011-05-05 2014-06-06 Universidad De Zaragoza Procedimiento de obtención de materiales multifuncionalizados
US20130078740A1 (en) * 2011-09-23 2013-03-28 University Of Rochester Preparation of microfluidic device on metal nanoparticle coated surface, and use thereof for nucleic acid detection
CN102527453B (zh) * 2011-12-30 2014-03-12 广州意迪欣医药技术有限公司 一种应用于纳米颗粒制备的高并行微流道芯片
CN203164120U (zh) * 2012-03-30 2013-08-28 北京博晖创新光电技术股份有限公司 微流控时间分辨荧光免疫分析装置
CA2906237A1 (en) * 2013-03-15 2014-09-18 Concordia University Methods for fabricating morphologically transformed nano-structures (mtns) and tunable nanocomposite polymer materials, and devices using such materials
CN105149020A (zh) * 2015-07-01 2015-12-16 北京航空航天大学 一种嵌入微纳结构端面光纤的拉曼检测微流控芯片
CN105062974A (zh) * 2015-08-03 2015-11-18 苏州大学 一种癌细胞或细菌的捕获方法及其试剂盒

Also Published As

Publication number Publication date
RU2018137413A (ru) 2020-04-29
WO2017167769A1 (en) 2017-10-05
CN109475861A (zh) 2019-03-15
JP2019515310A (ja) 2019-06-06
EP3436193A1 (en) 2019-02-06
US20190118174A1 (en) 2019-04-25

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired