EA201391378A1 - Обнаружение биомаркеров в сложных биологических жидкостях с использованием библиотек и диагностических наборов на основе бусин или частиц и лекарственные средства - Google Patents

Обнаружение биомаркеров в сложных биологических жидкостях с использованием библиотек и диагностических наборов на основе бусин или частиц и лекарственные средства

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EA201391378A1
EA201391378A1 EA201391378A EA201391378A EA201391378A1 EA 201391378 A1 EA201391378 A1 EA 201391378A1 EA 201391378 A EA201391378 A EA 201391378A EA 201391378 A EA201391378 A EA 201391378A EA 201391378 A1 EA201391378 A1 EA 201391378A1
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libraries
diseases
biomarkers
ligands
screening
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EA201391378A
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EA032582B1 (ru
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Муралидхар Редди Моола
Джессика Шилке
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ОПКО ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
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Publication of EA201391378A1 publication Critical patent/EA201391378A1/ru
Publication of EA032582B1 publication Critical patent/EA032582B1/ru

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Abstract

Изобретение можно применять для скрининга на биомаркеры, ассоциированные с болезнью или состоянием. Такие болезни и состояния включают неврологические заболевания, аутоиммунные заболевания и онкологические заболевания, указанные выше, а также любые болезни или состояния, для которых существует биомаркер, такой как антитело или другой хараткристический белок или биомолекула, ассоциированные с данной болезнью или ее течением. Большие библиотеки лигандов согласно настоящему изобретению можно применять непосредственно в биологической жидкости, в соответствующих экспериментальных условиях и в соответствии с описанными в настоящей заявке способами, для скрининга на такие маркеры, при этом нет необходимости использовать меньше носителей (например, приблизительно 100,000 или меньше) или переносить такие пептоиды или лиганды на микроматрицы перед скринингом биологической жидкости. Кроме того, библиотеки лигандов можно также применять для скрининга на клеточные рецепторы, которые специфично связаны с конкретным маркером клеточной поверхности.
EA201391378A 2011-03-24 2012-03-22 Библиотека случайных пептоидных лигандов для скрининга биологической жидкости EA032582B1 (ru)

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US201161467256P 2011-03-24 2011-03-24
US201161491717P 2011-05-31 2011-05-31
US201261583881P 2012-01-06 2012-01-06
PCT/US2012/030161 WO2012129423A2 (en) 2011-03-24 2012-03-22 Biomarker discovery in complex biological fluid using bead or particle based libraries and diagnostic kits and therapeutics

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EA201391378A1 true EA201391378A1 (ru) 2014-09-30
EA032582B1 EA032582B1 (ru) 2019-06-28

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EA201391378A EA032582B1 (ru) 2011-03-24 2012-03-22 Библиотека случайных пептоидных лигандов для скрининга биологической жидкости
EA201391382A EA037648B1 (ru) 2011-03-24 2012-03-23 Способ диагностики с использованием библиотеки пептоидных лигандов

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US (2) US9804168B2 (ru)
EP (2) EP2688911B1 (ru)
JP (2) JP6153921B2 (ru)
KR (2) KR20140027174A (ru)
CN (2) CN103748270B (ru)
AU (2) AU2012230880B2 (ru)
BR (2) BR112013024453A2 (ru)
CL (2) CL2013002732A1 (ru)
CO (2) CO6870029A2 (ru)
EA (2) EA032582B1 (ru)
HK (1) HK1197088A1 (ru)
MX (2) MX2013011000A (ru)
TW (2) TWI630389B (ru)
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