EA201390507A1 - Эмульсия циклоспорина - Google Patents
Эмульсия циклоспоринаInfo
- Publication number
- EA201390507A1 EA201390507A1 EA201390507A EA201390507A EA201390507A1 EA 201390507 A1 EA201390507 A1 EA 201390507A1 EA 201390507 A EA201390507 A EA 201390507A EA 201390507 A EA201390507 A EA 201390507A EA 201390507 A1 EA201390507 A1 EA 201390507A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cyclosporin
- emulsion
- cyclosporin emulsion
- phosphatidylcholine
- glycerin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Настоящее изобретение относится к эмульсии циклоспорина, содержащей: i) циклоспорин, ii) натуральное масло (длинноцепочечный триглицерид), iii) фосфатидилхолин, iv) глицерин, v) фармацевтически приемлемую щелочную соль свободной жирной кислоты, vi) масло, содержащее среднецепочечные триглицериды, vii) при необходимости соляную кислоту или гидроксид натрия для доведения значения рН, viii) воду.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38863310P | 2010-10-01 | 2010-10-01 | |
DKPA201000891 | 2010-10-01 | ||
PCT/EP2011/067117 WO2012042023A2 (en) | 2010-10-01 | 2011-09-30 | Cyclosporine emulsion |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201390507A1 true EA201390507A1 (ru) | 2013-08-30 |
EA027081B1 EA027081B1 (ru) | 2017-06-30 |
Family
ID=43733181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201390507A EA027081B1 (ru) | 2010-10-01 | 2011-09-30 | Эмульсия циклоспорина |
Country Status (15)
Country | Link |
---|---|
US (2) | US9040487B2 (ru) |
EP (1) | EP2621469B1 (ru) |
JP (1) | JP5860468B2 (ru) |
KR (1) | KR101801430B1 (ru) |
CN (2) | CN103118664B (ru) |
AU (1) | AU2011310111C9 (ru) |
CA (1) | CA2812901C (ru) |
CL (1) | CL2013000865A1 (ru) |
EA (1) | EA027081B1 (ru) |
ES (1) | ES2597959T3 (ru) |
HK (1) | HK1208357A1 (ru) |
IL (1) | IL225300A (ru) |
MX (2) | MX340897B (ru) |
PL (1) | PL2621469T3 (ru) |
WO (1) | WO2012042023A2 (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012128014A1 (ja) * | 2011-03-23 | 2012-09-27 | テルモ株式会社 | 成分測定装置 |
US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
KR101211902B1 (ko) * | 2012-04-30 | 2012-12-13 | 주식회사 휴온스 | 사이클로스포린 함유 무자극성 나노에멀젼 안약 조성물 |
CN106456541A (zh) * | 2014-02-14 | 2017-02-22 | 黄敬珺 | 纳米乳传递系统组合物 |
CN104055749B (zh) * | 2014-05-27 | 2017-05-24 | 无锡曙辉药业有限公司 | 环孢素a的自微乳化软胶囊内容物组合及其制备方法 |
CN105267144B (zh) * | 2014-07-04 | 2020-08-18 | 四川科伦药业股份有限公司 | 一种环孢素脂肪乳注射液 |
WO2017147470A1 (en) * | 2016-02-26 | 2017-08-31 | The Regents Of The University Of California | Bicontinuous microemulsions and methods of use thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2052016T3 (es) | 1988-09-29 | 1994-07-01 | Shiseido Co Ltd | Composicion emulsionada. |
US5527537A (en) * | 1992-05-18 | 1996-06-18 | Dietl; Hans | Pharmaceutical preparation containing cyclosporine(s) for intravenous administration and a process for its production |
JP3200639B2 (ja) | 1992-05-19 | 2001-08-20 | カシオ計算機株式会社 | 薄膜トランジスタパネルの製造方法 |
US5660858A (en) * | 1996-04-03 | 1997-08-26 | Research Triangle Pharmaceuticals | Cyclosporin emulsions |
KR980008239A (ko) | 1996-07-26 | 1998-04-30 | 김충환 | 사이클로스포린-함유 약학적 조성물 |
DE19961733A1 (de) * | 1999-12-21 | 2001-06-28 | Ciclomulsion Ag | Cyclosporin(e) enthaltende hypertone pharmazeutische Zubereitung zur Anwendung bei neurologischen Erkrankungen und als Neuroprotektivum sowie Verfahren zu ihrer Herstellung |
CA2578176C (en) * | 2004-11-09 | 2013-09-24 | Novagali Pharma Sa | Ophthalmic emulsions containing an immunosuppressive agent |
CN101904814A (zh) * | 2009-06-04 | 2010-12-08 | 上海恒瑞医药有限公司 | 制备载药乳剂的方法 |
-
2010
- 2010-03-30 MX MX2015002505A patent/MX340897B/es unknown
-
2011
- 2011-09-30 CN CN201180028018.7A patent/CN103118664B/zh active Active
- 2011-09-30 JP JP2013530754A patent/JP5860468B2/ja active Active
- 2011-09-30 AU AU2011310111A patent/AU2011310111C9/en active Active
- 2011-09-30 US US13/877,326 patent/US9040487B2/en active Active
- 2011-09-30 CA CA2812901A patent/CA2812901C/en active Active
- 2011-09-30 EA EA201390507A patent/EA027081B1/ru not_active IP Right Cessation
- 2011-09-30 ES ES11767671.8T patent/ES2597959T3/es active Active
- 2011-09-30 WO PCT/EP2011/067117 patent/WO2012042023A2/en active Application Filing
- 2011-09-30 EP EP11767671.8A patent/EP2621469B1/en active Active
- 2011-09-30 CN CN201410693438.2A patent/CN104548064A/zh active Pending
- 2011-09-30 MX MX2013003578A patent/MX336100B/es unknown
- 2011-09-30 PL PL11767671T patent/PL2621469T3/pl unknown
- 2011-09-30 KR KR1020137010187A patent/KR101801430B1/ko active IP Right Grant
-
2013
- 2013-03-18 IL IL225300A patent/IL225300A/en active IP Right Grant
- 2013-03-28 CL CL2013000865A patent/CL2013000865A1/es unknown
-
2015
- 2015-03-04 US US14/638,647 patent/US20150238563A1/en not_active Abandoned
- 2015-09-16 HK HK15109046.8A patent/HK1208357A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US20130323270A1 (en) | 2013-12-05 |
CN103118664B (zh) | 2015-11-25 |
ES2597959T3 (es) | 2017-01-24 |
AU2011310111C1 (en) | 2015-05-07 |
IL225300A0 (en) | 2013-06-27 |
AU2011310111B2 (en) | 2014-08-14 |
CA2812901C (en) | 2019-02-19 |
JP2013538843A (ja) | 2013-10-17 |
AU2011310111B9 (en) | 2016-11-24 |
PL2621469T3 (pl) | 2017-01-31 |
MX340897B (es) | 2016-07-29 |
KR101801430B1 (ko) | 2017-11-24 |
IL225300A (en) | 2017-06-29 |
CA2812901A1 (en) | 2012-04-05 |
CL2013000865A1 (es) | 2014-03-28 |
JP5860468B2 (ja) | 2016-02-16 |
EP2621469B1 (en) | 2016-07-20 |
AU2011310111A1 (en) | 2013-04-04 |
US9040487B2 (en) | 2015-05-26 |
HK1208357A1 (en) | 2016-03-04 |
CN104548064A (zh) | 2015-04-29 |
AU2011310111C9 (en) | 2016-11-24 |
MX336100B (es) | 2016-01-08 |
CN103118664A (zh) | 2013-05-22 |
MX2013003578A (es) | 2013-10-25 |
KR20130124944A (ko) | 2013-11-15 |
WO2012042023A3 (en) | 2012-06-21 |
US20150238563A1 (en) | 2015-08-27 |
EP2621469A2 (en) | 2013-08-07 |
EA027081B1 (ru) | 2017-06-30 |
WO2012042023A2 (en) | 2012-04-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
TC4A | Change in name of a patent proprietor in a eurasian patent |