EA201301316A1 - Способ получения интермедиатов эстетрола - Google Patents

Способ получения интермедиатов эстетрола

Info

Publication number
EA201301316A1
EA201301316A1 EA201301316A EA201301316A EA201301316A1 EA 201301316 A1 EA201301316 A1 EA 201301316A1 EA 201301316 A EA201301316 A EA 201301316A EA 201301316 A EA201301316 A EA 201301316A EA 201301316 A1 EA201301316 A1 EA 201301316A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound
formula
group
alkyl
reacting
Prior art date
Application number
EA201301316A
Other languages
English (en)
Other versions
EA023991B1 (ru
Inventor
Жан-Клод Паскаль
Original Assignee
Эстетра С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эстетра С.А. filed Critical Эстетра С.А.
Publication of EA201301316A1 publication Critical patent/EA201301316A1/ru
Publication of EA023991B1 publication Critical patent/EA023991B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к способу получения соединения формулы (I)включающему следующие стадии: а) взаимодействие соединения формулы (II) с ацилирующим или с силилирующим агентом с получением соединения формулы (III), где Ри Р, каждый независимо, представляет собой защитную группу, выбранную из R-Si-RRили RCO-, где Rпредставляет собой группу, выбранную из Cалкильной или С-циклоалкильной группы, каждая из которых может быть необязательно замещена одним или несколькими заместителями, независимо выбранными из фтора или Cалкильной группы; R, Rи Rкаждый независимо представляет собой группу, выбранную из Cалкильной или фенильной группы, каждая из которых может быть необязательно замещена одним или несколькими заместителями, независимо выбранными из фтора или Cалкильной группы;b) взаимодействие соединения формулы (III) в присутствии ацетата палладия или его производного с получением соединения формулы (IV); ис) взаимодействие соединения формулы (IV) с восстановителем с получением соединения формулы (I).
EA201301316A 2011-06-01 2012-06-01 Способ получения интермедиатов эстетрола EA023991B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161492300P 2011-06-01 2011-06-01
EP11168561 2011-06-01
PCT/EP2012/060447 WO2012164096A1 (en) 2011-06-01 2012-06-01 Process for the production of estetrol intermediates

Publications (2)

Publication Number Publication Date
EA201301316A1 true EA201301316A1 (ru) 2014-04-30
EA023991B1 EA023991B1 (ru) 2016-08-31

Family

ID=45003353

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201301316A EA023991B1 (ru) 2011-06-01 2012-06-01 Способ получения интермедиатов эстетрола

Country Status (24)

Country Link
US (1) US11053274B2 (ru)
EP (1) EP2714710B1 (ru)
JP (2) JP6425540B2 (ru)
KR (1) KR101994805B1 (ru)
CN (2) CN107266514A (ru)
AU (1) AU2012264602B2 (ru)
BR (1) BR112013030830B1 (ru)
CA (1) CA2835981C (ru)
CY (1) CY1118150T1 (ru)
DK (1) DK2714710T3 (ru)
EA (1) EA023991B1 (ru)
ES (1) ES2579175T3 (ru)
HR (1) HRP20160692T2 (ru)
HU (1) HUE029252T2 (ru)
ME (1) ME02454B (ru)
MX (1) MX341561B (ru)
PL (1) PL2714710T3 (ru)
PT (1) PT2714710T (ru)
RS (1) RS54880B1 (ru)
SG (1) SG195118A1 (ru)
SI (1) SI2714710T1 (ru)
SM (1) SMT201600206B (ru)
WO (1) WO2012164096A1 (ru)
ZA (1) ZA201308446B (ru)

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PT2764008T (pt) 2011-10-07 2016-11-10 Estetra Sprl Processo para a produção de estetrol
MY195019A (en) 2015-06-18 2023-01-03 Estetra Sprl Orodispersible dosage unit containing an estetrol component
HUE054551T2 (hu) 2015-06-18 2021-09-28 Estetra Sprl Ösztetrolt tartalmazó, szájban diszpergálódó tabletta
UA123099C2 (uk) 2015-06-18 2021-02-17 Естетра Спрл Диспергована в порожнині рота одиниця дозування, яка містить естетрольний компонент
LT3310345T (lt) 2015-06-18 2021-06-25 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
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Also Published As

Publication number Publication date
CA2835981A1 (en) 2012-12-06
HUE029252T2 (en) 2017-02-28
KR20140036205A (ko) 2014-03-25
CN107266514A (zh) 2017-10-20
MX2013014045A (es) 2014-08-22
MX341561B (es) 2016-08-25
NZ617613A (en) 2015-12-24
PL2714710T3 (pl) 2017-03-31
HRP20160692T2 (hr) 2016-09-23
AU2012264602B2 (en) 2017-03-09
HRP20160692T1 (hr) 2016-08-12
PT2714710T (pt) 2016-07-12
JP6425540B2 (ja) 2018-11-21
ZA201308446B (en) 2016-08-31
BR112013030830A2 (pt) 2016-08-30
DK2714710T3 (en) 2016-06-27
BR112013030830B1 (pt) 2019-12-03
SG195118A1 (en) 2013-12-30
US20140107358A1 (en) 2014-04-17
EP2714710B1 (en) 2016-04-06
KR101994805B1 (ko) 2019-07-01
CN103703014A (zh) 2014-04-02
US11053274B2 (en) 2021-07-06
ES2579175T3 (es) 2016-08-05
EA023991B1 (ru) 2016-08-31
CY1118150T1 (el) 2017-06-28
SI2714710T1 (sl) 2016-08-31
JP2014518199A (ja) 2014-07-28
RS54880B1 (sr) 2016-10-31
EP2714710A1 (en) 2014-04-09
JP6479912B2 (ja) 2019-03-06
WO2012164096A1 (en) 2012-12-06
CA2835981C (en) 2018-07-24
ME02454B (me) 2016-09-20
SMT201600206B (it) 2016-08-31
JP2018024673A (ja) 2018-02-15

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