EA201100013A1 - Фармацевтические композиции на основе антагонистов кининового рецептора b2 и кортикостероидов и их применение - Google Patents

Фармацевтические композиции на основе антагонистов кининового рецептора b2 и кортикостероидов и их применение

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Publication number
EA201100013A1
EA201100013A1 EA201100013A EA201100013A EA201100013A1 EA 201100013 A1 EA201100013 A1 EA 201100013A1 EA 201100013 A EA201100013 A EA 201100013A EA 201100013 A EA201100013 A EA 201100013A EA 201100013 A1 EA201100013 A1 EA 201100013A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical compositions
corticosteroids
antagonists
application
compositions based
Prior art date
Application number
EA201100013A
Other languages
English (en)
Other versions
EA019903B1 (ru
Inventor
Сандро Джулиани
Карло Альберто Маджи
Original Assignee
ИСТИТУТО ЛУЗО ФАРМАКО Д'ИТАЛИЯ С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by ИСТИТУТО ЛУЗО ФАРМАКО Д'ИТАЛИЯ С.п.А. filed Critical ИСТИТУТО ЛУЗО ФАРМАКО Д'ИТАЛИЯ С.п.А.
Publication of EA201100013A1 publication Critical patent/EA201100013A1/ru
Publication of EA019903B1 publication Critical patent/EA019903B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Раскрыты фармацевтические композиции, содержащие в качестве активных ингредиентов смесь кортикостероида и антагониста кининового рецептора В2. Указанные композиции оказались особенно эффективными, особенно в лечении воспалительных расстройств, таких как астма, офтальмологических или дерматологических расстройств и, главным образом, в отношении суставов, артрита.
EA201100013A 2008-07-11 2009-07-03 Фармацевтические композиции на основе антагонистов кининового рецептора в2 и кортикостероидов и их применение EA019903B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2008A001264A IT1391236B1 (it) 2008-07-11 2008-07-11 Composizioni farmaceutiche a base di antagonisti del recettore b2 delle chinine e corticosteroidi e loro uso
PCT/EP2009/004847 WO2010003601A1 (en) 2008-07-11 2009-07-03 Pharmaceutical compositions based on kinin b2 receptor antagonists and corticosteroids, and their use

Publications (2)

Publication Number Publication Date
EA201100013A1 true EA201100013A1 (ru) 2011-08-30
EA019903B1 EA019903B1 (ru) 2014-07-30

Family

ID=40466843

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100013A EA019903B1 (ru) 2008-07-11 2009-07-03 Фармацевтические композиции на основе антагонистов кининового рецептора в2 и кортикостероидов и их применение

Country Status (36)

Country Link
US (1) US8476276B2 (ru)
EP (1) EP2303268B1 (ru)
JP (1) JP5791501B2 (ru)
KR (1) KR101656324B1 (ru)
CN (1) CN102088975B (ru)
AP (1) AP2803A (ru)
AR (1) AR072734A1 (ru)
AU (1) AU2009267416B2 (ru)
BR (1) BRPI0915866A2 (ru)
CA (1) CA2730420A1 (ru)
CO (1) CO6341556A2 (ru)
CR (1) CR20110021A (ru)
CY (1) CY1112900T1 (ru)
DK (1) DK2303268T3 (ru)
EA (1) EA019903B1 (ru)
EC (1) ECSP11010752A (ru)
ES (1) ES2389872T3 (ru)
GE (1) GEP20135792B (ru)
HK (1) HK1158547A1 (ru)
HN (1) HN2011000089A (ru)
HR (1) HRP20120678T1 (ru)
IL (1) IL210554A0 (ru)
IT (1) IT1391236B1 (ru)
MA (1) MA32542B1 (ru)
MX (1) MX2011000350A (ru)
MY (1) MY150477A (ru)
NI (1) NI201100014A (ru)
NZ (1) NZ590427A (ru)
PL (1) PL2303268T3 (ru)
PT (1) PT2303268E (ru)
RS (1) RS52418B (ru)
SI (1) SI2303268T1 (ru)
TW (1) TWI499419B (ru)
UA (1) UA100060C2 (ru)
WO (1) WO2010003601A1 (ru)
ZA (1) ZA201100287B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120190653A1 (en) * 2011-01-20 2012-07-26 Dow Pharmaceutical Sciences, Inc. Therapeutic eye drop comprising doxycycline and a stabilizer
RU2015138443A (ru) * 2013-03-14 2017-04-20 Шир Хьюман Дженетик Терапис, Инк. Способы лечения ангионевротического отека, опосредованного рецепторами брадикинина в2
CN104072585A (zh) * 2014-07-21 2014-10-01 成都圣诺生物科技股份有限公司 一种合成艾替班特的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03011795A (es) * 2001-06-26 2005-10-18 Metaphore Pharmaceuticals Inc Terapia de combinacion de una superoxido dismutasa mimetica y un corticosteroide para la prevencion y/o el tratamiento de una enfermedad inflamatoria.
ITMI20021247A1 (it) * 2002-06-07 2003-12-09 Menarini Ricerche Spa Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche
DE10304994A1 (de) * 2003-02-07 2004-09-02 Aventis Pharma Deutschland Gmbh Die Verwendung von Antagonisten des Bradykinin-B2 Rezeptors zur Behandlung von Osteoarthrose
ITMI20041963A1 (it) * 2004-10-15 2005-01-15 Luso Farmaco Inst "antagonisti non-peptidici della bradichinina e loro composizioni farmaceutiche"
EP1741444A1 (en) * 2005-07-05 2007-01-10 Jerini AG Kinin antagonists for treating bladder dysfunction
EP1894559A1 (en) * 2006-09-01 2008-03-05 PARI Pharma GmbH Means to solubilise steroids for inhalation

Also Published As

Publication number Publication date
EP2303268A1 (en) 2011-04-06
CA2730420A1 (en) 2010-01-14
MY150477A (en) 2014-01-30
NI201100014A (es) 2011-09-13
NZ590427A (en) 2012-09-28
AU2009267416B2 (en) 2013-09-12
ZA201100287B (en) 2012-03-28
UA100060C2 (ru) 2012-11-12
TWI499419B (zh) 2015-09-11
AP2011005572A0 (en) 2011-02-28
GEP20135792B (en) 2013-03-25
HN2011000089A (es) 2013-01-28
DK2303268T3 (da) 2012-07-23
KR20110044970A (ko) 2011-05-03
CO6341556A2 (es) 2011-11-21
ECSP11010752A (es) 2011-04-29
SI2303268T1 (sl) 2012-10-30
CY1112900T1 (el) 2016-04-13
MX2011000350A (es) 2011-02-22
BRPI0915866A2 (pt) 2015-11-03
CR20110021A (es) 2011-07-11
WO2010003601A8 (en) 2010-03-18
ES2389872T3 (es) 2012-11-02
IL210554A0 (en) 2011-03-31
JP2011527296A (ja) 2011-10-27
PL2303268T3 (pl) 2012-11-30
AR072734A1 (es) 2010-09-15
CN102088975B (zh) 2013-08-21
AP2803A (en) 2013-11-30
TW201006471A (en) 2010-02-16
HRP20120678T1 (hr) 2012-09-30
EA019903B1 (ru) 2014-07-30
US8476276B2 (en) 2013-07-02
ITMI20081264A1 (it) 2010-01-12
US20110112011A1 (en) 2011-05-12
CN102088975A (zh) 2011-06-08
AU2009267416A1 (en) 2010-01-14
KR101656324B1 (ko) 2016-09-09
IT1391236B1 (it) 2011-12-01
EP2303268B1 (en) 2012-06-20
WO2010003601A1 (en) 2010-01-14
MA32542B1 (fr) 2011-08-01
JP5791501B2 (ja) 2015-10-07
HK1158547A1 (en) 2012-07-20
RS52418B (en) 2013-02-28
PT2303268E (pt) 2012-09-24

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EA201100013A1 (ru) Фармацевтические композиции на основе антагонистов кининового рецептора b2 и кортикостероидов и их применение

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU