EA201000972A1 - Способ получения дендритных клеток - Google Patents

Способ получения дендритных клеток

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Publication number
EA201000972A1
EA201000972A1 EA201000972A EA201000972A EA201000972A1 EA 201000972 A1 EA201000972 A1 EA 201000972A1 EA 201000972 A EA201000972 A EA 201000972A EA 201000972 A EA201000972 A EA 201000972A EA 201000972 A1 EA201000972 A1 EA 201000972A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dendritic cells
obtaining dendritic
obtaining
rejection
aimed
Prior art date
Application number
EA201000972A
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English (en)
Other versions
EA023106B1 (ru
Inventor
Томас Фельцман
Александр Михаель Дональ
Original Assignee
Тримед Биотех Гмбх
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Publication date
Application filed by Тримед Биотех Гмбх filed Critical Тримед Биотех Гмбх
Publication of EA201000972A1 publication Critical patent/EA201000972A1/ru
Publication of EA023106B1 publication Critical patent/EA023106B1/ru

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4615—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/4643—Vertebrate antigens
    • A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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    • A61K39/4643—Vertebrate antigens
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464416—Receptors for cytokines
    • A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/464838—Viral antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • C12N5/064—Immunosuppressive dendritic cells
    • A—HUMAN NECESSITIES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к способу получения дендритных клеток и их применению в медикаментах с помощью генной инженерии, направленной на функциональное улучшение их терапевтической эффективности при лечении рака, микробных инфекций, аллергических реакций, аутоиммунных болезней или отторжения трансплантата стволовых клеток или органа.
EA201000972A 2007-12-12 2008-12-12 Способ получения частично зрелых дендритных клеток, обладающих повышенной экспрессией интерлейкина il-12 EA023106B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07450233A EP2072617A1 (en) 2007-12-12 2007-12-12 Method for producing dendritic cells
PCT/EP2008/010606 WO2009074341A1 (en) 2007-12-12 2008-12-12 Method for producing dendritic cells

Publications (2)

Publication Number Publication Date
EA201000972A1 true EA201000972A1 (ru) 2010-12-30
EA023106B1 EA023106B1 (ru) 2016-04-29

Family

ID=39325869

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000972A EA023106B1 (ru) 2007-12-12 2008-12-12 Способ получения частично зрелых дендритных клеток, обладающих повышенной экспрессией интерлейкина il-12

Country Status (13)

Country Link
US (1) US9303246B2 (ru)
EP (2) EP2072617A1 (ru)
JP (1) JP5730577B2 (ru)
KR (1) KR101590199B1 (ru)
CN (1) CN101896601B (ru)
AU (1) AU2008334914B9 (ru)
BR (1) BRPI0819936A2 (ru)
CA (1) CA2709209C (ru)
EA (1) EA023106B1 (ru)
MX (1) MX2010006434A (ru)
NZ (1) NZ585898A (ru)
WO (1) WO2009074341A1 (ru)
ZA (1) ZA201003193B (ru)

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CN105821029A (zh) * 2015-01-04 2016-08-03 彭霞 异源融合基因修饰的癌细胞/树突状细胞融合肿瘤疫苗及其制备方法
CN105821030A (zh) * 2015-01-04 2016-08-03 彭霞 表达α1，3半乳糖转移酶的癌细胞/树突状细胞融合肿瘤疫苗及其制备方法
CN104630145A (zh) * 2015-01-12 2015-05-20 杨世成 一种抗肿瘤t细胞、其制备方法和抗肿瘤药物
EP3250250A4 (en) 2015-01-30 2019-05-22 President and Fellows of Harvard College PERITUMORAL AND INTRATUMORAL MATERIALS FOR CANCER THERAPY
JP7094533B2 (ja) 2015-04-10 2022-07-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 免疫細胞捕捉デバイスおよびその製造および使用方法
CN114774356A (zh) 2015-06-30 2022-07-22 西北生物治疗药物公司 诱发改善的或增加的抗肿瘤免疫应答的经最佳活化的树突细胞
CN108291204A (zh) * 2015-09-15 2018-07-17 西北生物治疗药物公司 涉及用于患有晚期癌症的受试者的经活化树突状细胞组合物和免疫治疗处理的方法
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CN105219720A (zh) * 2015-10-20 2016-01-06 上海隆耀生物科技有限公司 一种用于激活肝癌特异性免疫反应的试剂盒
CN105219714A (zh) * 2015-10-20 2016-01-06 上海隆耀生物科技有限公司 一种用于激活肺癌特异性免疫反应的试剂盒
CN105219715A (zh) * 2015-10-20 2016-01-06 上海隆耀生物科技有限公司 一种用于激活食管癌特异性免疫反应的试剂盒
JP7171433B2 (ja) * 2015-10-30 2022-11-15 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ Ｈｅｒ－２発現固形腫瘍の処置のための組成物および方法
JP7138864B2 (ja) 2016-02-06 2022-09-20 プレジデント アンド フェローズ オブ ハーバード カレッジ 免疫を再構成するための造血ニッチの再現
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BRPI0819936A2 (pt) 2015-05-26
NZ585898A (en) 2012-01-12
EA023106B1 (ru) 2016-04-29
KR101590199B1 (ko) 2016-01-29
CN101896601B (zh) 2014-09-03
WO2009074341A1 (en) 2009-06-18
US9303246B2 (en) 2016-04-05
JP5730577B2 (ja) 2015-06-10
AU2008334914A1 (en) 2009-06-18
EP2072617A1 (en) 2009-06-24
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ZA201003193B (en) 2011-10-26
MX2010006434A (es) 2011-05-02
AU2008334914B9 (en) 2013-09-26
CN101896601A (zh) 2010-11-24
KR20100101094A (ko) 2010-09-16
CA2709209A1 (en) 2009-06-18
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AU2008334914B2 (en) 2013-08-01
US20100285072A1 (en) 2010-11-11

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