EA200900808A1 - Антагонисты рецепторов ангиотензина ii - Google Patents

Антагонисты рецепторов ангиотензина ii

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Publication number
EA200900808A1
EA200900808A1 EA200900808A EA200900808A EA200900808A1 EA 200900808 A1 EA200900808 A1 EA 200900808A1 EA 200900808 A EA200900808 A EA 200900808A EA 200900808 A EA200900808 A EA 200900808A EA 200900808 A1 EA200900808 A1 EA 200900808A1
Authority
EA
Eurasian Patent Office
Prior art keywords
group
hydrogen
angiotensin
antagonists
receptors
Prior art date
Application number
EA200900808A
Other languages
English (en)
Inventor
Яссу К. Себат
Майкл Мэн-Чу Ло
Рави П. Наругунд
Амджад Али
Крис Франклин
Николетта Алмиранте
Лаура Сторони
Сильвия Стефанини
Original Assignee
Мерк Энд Ко., Инк.
Никокс С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Энд Ко., Инк., Никокс С.А. filed Critical Мерк Энд Ко., Инк.
Publication of EA200900808A1 publication Critical patent/EA200900808A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение относится к соединению, имеющему структуру (формула 1), в которой R является активной группой антагониста рецептора ангиотензина, Y представляет собой -Y-Y-Y-Y-Y; Yпредставляет собой C(RR); Rвыбирают из группы, состоящей из водорода и Cалкила; Rвыбирают из группы, состоящей из водорода и Cалкила и -OC(O)Cалкила; Yпредставляет собой О или СН; Yпредставляет собой С(O) или СН; Yпредставляет собой О или СН; Yявляется -(CH)--(X)-(CH)или отсутствует; Х является -О- или -CRR-; и R, и Rявляются независимо выбранными из группы, состоящей из водорода и С-Салкила; или его фармацевтически приемлемой соли или гидрату, которое применяется для лечения гипертензии.
EA200900808A 2006-12-13 2007-12-11 Антагонисты рецепторов ангиотензина ii EA200900808A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87463006P 2006-12-13 2006-12-13
PCT/US2007/025233 WO2008076247A2 (en) 2006-12-13 2007-12-11 Nitroderivatives as angiotensin ii receptor antagonists

Publications (1)

Publication Number Publication Date
EA200900808A1 true EA200900808A1 (ru) 2009-12-30

Family

ID=39536882

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900808A EA200900808A1 (ru) 2006-12-13 2007-12-11 Антагонисты рецепторов ангиотензина ii

Country Status (18)

Country Link
US (2) US20100152259A1 (ru)
EP (1) EP2121665B1 (ru)
JP (1) JP2010513274A (ru)
KR (1) KR20090103916A (ru)
CN (1) CN101547918A (ru)
AR (1) AR064306A1 (ru)
AU (1) AU2007334522B2 (ru)
CA (1) CA2671673A1 (ru)
CL (1) CL2007003613A1 (ru)
DO (1) DOP2009000139A (ru)
EA (1) EA200900808A1 (ru)
MX (1) MX2009006210A (ru)
NO (1) NO20092638L (ru)
PE (1) PE20081382A1 (ru)
TN (1) TN2009000236A1 (ru)
TW (1) TW200831079A (ru)
WO (2) WO2008076246A2 (ru)
ZA (1) ZA200904479B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200831079A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Angiotensin II receptor antagonists
AR069340A1 (es) * 2007-11-26 2010-01-13 Merck & Co Inc Antagonistas del receptor de angiotensina ii
WO2009150007A1 (en) * 2008-06-09 2009-12-17 Nicox S.A. Angiotensin ii receptor antagonists
AR073259A1 (es) * 2008-07-29 2010-10-28 Merck & Co Inc Derivados de furosemida utiles como diureticos
AR074425A1 (es) 2008-12-05 2011-01-19 Merck Sharp & Dohme Derivados de nitrooxi como antagonistas del receptor de angiotensina ii.
JO3350B1 (ar) 2011-03-07 2019-03-13 Merck Sharp & Dohme مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
CN105218527B (zh) * 2015-10-10 2018-04-24 江苏宝众宝达药业有限公司 一种exp-3174的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
IT1243367B (it) 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1295694B1 (it) * 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
IT1311923B1 (it) 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1311924B1 (it) 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1314184B1 (it) * 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
EP1603933A2 (en) * 2003-03-13 2005-12-14 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods of use
US20060276523A1 (en) 2003-07-31 2006-12-07 Nicoletta Almirante Nitoroxy derivatives of losartan, valsatan, candesartan, telmisartan, eprosartan and olmesartan as angiotensin-II receptor blockers for the treatment of cardiovascular diseases
WO2005023182A2 (en) 2003-08-28 2005-03-17 Nitromed, Inc. Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
EP1711454A4 (en) * 2004-01-27 2007-04-04 Merck Frosst Company COMBINATION THERAPY FOR TREATING DISEASES OR CONDITIONS INDUCED BY CYCLOOXYGENASE-2 IN PATIENTS WITH RISK OF THROMBOTIC CARDIOVASCULAR EVENTS
WO2006079610A1 (en) 2005-01-31 2006-08-03 Nicox S.A. Nitrooxy sartan derivatives as angiotensin ii receptor blockers for the treatment of cardiovascular and inflammatory diseases
AU2006216665A1 (en) * 2005-02-24 2006-08-31 Nicox S.A. Nitric oxide enhancing diuretic compounds, compositions and methods of use
WO2007019448A2 (en) * 2005-08-08 2007-02-15 Nitromed, Inc. Nitric oxide enhancing angiotensin ii antagonist compounds, compositions and methods of use
EP2121664B1 (en) * 2006-12-13 2013-10-16 Merck Sharp & Dohme Corp. Dinitrate derivatives as angiotensin ii receptor antagonists
TW200831079A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Angiotensin II receptor antagonists
AR069340A1 (es) * 2007-11-26 2010-01-13 Merck & Co Inc Antagonistas del receptor de angiotensina ii

Also Published As

Publication number Publication date
WO2008076246A2 (en) 2008-06-26
MX2009006210A (es) 2009-07-22
PE20081382A1 (es) 2008-09-18
WO2008076247A2 (en) 2008-06-26
AU2007334522A1 (en) 2008-06-26
NO20092638L (no) 2009-09-11
KR20090103916A (ko) 2009-10-01
DOP2009000139A (es) 2009-08-31
TW200831079A (en) 2008-08-01
WO2008076247A3 (en) 2009-01-15
EP2121665A2 (en) 2009-11-25
EP2121665B1 (en) 2014-01-22
ZA200904479B (en) 2010-09-29
AU2007334522B2 (en) 2012-03-15
TN2009000236A1 (en) 2010-10-18
AR064306A1 (es) 2009-03-25
US20100152259A1 (en) 2010-06-17
WO2008076246A3 (en) 2009-01-15
US7880014B2 (en) 2011-02-01
CA2671673A1 (en) 2008-06-26
CL2007003613A1 (es) 2008-07-11
US20080194660A1 (en) 2008-08-14
JP2010513274A (ja) 2010-04-30
CN101547918A (zh) 2009-09-30

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