AR064306A1 - Antagonistas del receptor de angiotensina ii - Google Patents
Antagonistas del receptor de angiotensina iiInfo
- Publication number
- AR064306A1 AR064306A1 ARP070105570A ARP070105570A AR064306A1 AR 064306 A1 AR064306 A1 AR 064306A1 AR P070105570 A ARP070105570 A AR P070105570A AR P070105570 A ARP070105570 A AR P070105570A AR 064306 A1 AR064306 A1 AR 064306A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- angiotensin
- hydrogen
- receiver antagonists
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un compuesto para uso farmacéutico o uno de sus hidratos. Es util para el tratamiento de la hipertension. Reivindicacion 1: Un compuesto que tiene la formula general (1) donde R se selecciona del grupo que consiste en el grupo de formulas (2); Y es -Y1-Y2-Y3-Y4-Y5-; Y1 es C(R1R2); R1 se selecciona del grupo que consiste en hidrogeno y alquilo C1-4; R2 se selecciona del grupo que consiste en hidrogeno, alquilo C1-4 y -OC(O)alquiloC1-4; Y2 es O, C(O), P(O)(OH) o CH2; Y3 es O, C(O) o CH2, siempre que cuando Y2 es C(O), entonces Y3 no es C(O), y además, siempre que cuando Y2 es O, entonces Y3 no es O, y cuando Y2 es P(O)(OH), entonces Y3 es O; Y4 es O o CH2, o está ausente, siempre que cuando Y3 es O, entonces Y4 no es O; Y5 es - (CH2)1-2-(X)0-1-(CH2)0-1- o está ausente; X es -O- o -CR3R4-; y R3 y R4 se seleccionan de manera independiente del grupo que consiste en hidrogeno y alquilo C1-4 o una de sus sales aceptables para uso farmacéutico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87463006P | 2006-12-13 | 2006-12-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR064306A1 true AR064306A1 (es) | 2009-03-25 |
Family
ID=39536882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070105570A AR064306A1 (es) | 2006-12-13 | 2007-12-12 | Antagonistas del receptor de angiotensina ii |
Country Status (18)
Country | Link |
---|---|
US (2) | US7880014B2 (es) |
EP (1) | EP2121665B1 (es) |
JP (1) | JP2010513274A (es) |
KR (1) | KR20090103916A (es) |
CN (1) | CN101547918A (es) |
AR (1) | AR064306A1 (es) |
AU (1) | AU2007334522B2 (es) |
CA (1) | CA2671673A1 (es) |
CL (1) | CL2007003613A1 (es) |
DO (1) | DOP2009000139A (es) |
EA (1) | EA200900808A1 (es) |
MX (1) | MX2009006210A (es) |
NO (1) | NO20092638L (es) |
PE (1) | PE20081382A1 (es) |
TN (1) | TN2009000236A1 (es) |
TW (1) | TW200831079A (es) |
WO (2) | WO2008076246A2 (es) |
ZA (1) | ZA200904479B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200831079A (en) * | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Angiotensin II receptor antagonists |
AR069340A1 (es) * | 2007-11-26 | 2010-01-13 | Merck & Co Inc | Antagonistas del receptor de angiotensina ii |
CA2724919A1 (en) * | 2008-06-09 | 2009-12-17 | Nicox S.A. | Angiotensin ii receptor antagonists |
AR073259A1 (es) * | 2008-07-29 | 2010-10-28 | Merck & Co Inc | Derivados de furosemida utiles como diureticos |
AR074425A1 (es) | 2008-12-05 | 2011-01-19 | Merck Sharp & Dohme | Derivados de nitrooxi como antagonistas del receptor de angiotensina ii. |
JO3350B1 (ar) | 2011-03-07 | 2019-03-13 | Merck Sharp & Dohme | مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات |
CN105218527B (zh) * | 2015-10-10 | 2018-04-24 | 江苏宝众宝达药业有限公司 | 一种exp-3174的制备方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
IT1243367B (it) | 1990-07-26 | 1994-06-10 | Italfarmaco Spa | Derivati acidi benzoici sostituiti ad attivita' cardiovascolare |
IT1295694B1 (it) * | 1996-11-14 | 1999-05-27 | Nicox Sa | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
IT1311923B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
IT1311924B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
IT1314184B1 (it) | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
EP1603933A2 (en) * | 2003-03-13 | 2005-12-14 | Nitromed, Inc. | Nitrosated and nitrosylated compounds, compositions and methods of use |
UA87983C2 (ru) * | 2003-07-31 | 2009-09-10 | Никокс С.А. | Производные блокиратора рецептора ангиотензина ii |
CA2536975A1 (en) * | 2003-08-28 | 2005-03-17 | Nitromed, Inc. | Nitrosated and nitrosylated diuretic compounds, compositions and methods of use |
CN1914149A (zh) * | 2004-01-27 | 2007-02-14 | 默克弗罗斯特公司 | 用于治疗处于血栓形成心血管事件危险中的患者的环氧合酶-2为媒的疾病或状况的组合治疗 |
WO2006079610A1 (en) | 2005-01-31 | 2006-08-03 | Nicox S.A. | Nitrooxy sartan derivatives as angiotensin ii receptor blockers for the treatment of cardiovascular and inflammatory diseases |
WO2006091716A2 (en) * | 2005-02-24 | 2006-08-31 | Nitromed, Inc. | Nitric oxide enhancing diuretic compounds, compositions and methods of use |
WO2007019448A2 (en) * | 2005-08-08 | 2007-02-15 | Nitromed, Inc. | Nitric oxide enhancing angiotensin ii antagonist compounds, compositions and methods of use |
TW200831079A (en) * | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Angiotensin II receptor antagonists |
AU2007334521B2 (en) * | 2006-12-13 | 2012-03-29 | Merck & Co., Inc. | Angiotensin II receptor antagonists |
AR069340A1 (es) * | 2007-11-26 | 2010-01-13 | Merck & Co Inc | Antagonistas del receptor de angiotensina ii |
-
2007
- 2007-12-07 TW TW096146849A patent/TW200831079A/zh unknown
- 2007-12-11 EA EA200900808A patent/EA200900808A1/ru unknown
- 2007-12-11 US US12/000,247 patent/US7880014B2/en not_active Expired - Fee Related
- 2007-12-11 WO PCT/US2007/025232 patent/WO2008076246A2/en active Application Filing
- 2007-12-11 AU AU2007334522A patent/AU2007334522B2/en not_active Ceased
- 2007-12-11 EP EP07862716.3A patent/EP2121665B1/en active Active
- 2007-12-11 ZA ZA200904479A patent/ZA200904479B/xx unknown
- 2007-12-11 MX MX2009006210A patent/MX2009006210A/es not_active Application Discontinuation
- 2007-12-11 CA CA002671673A patent/CA2671673A1/en not_active Abandoned
- 2007-12-11 US US12/516,482 patent/US20100152259A1/en not_active Abandoned
- 2007-12-11 WO PCT/US2007/025233 patent/WO2008076247A2/en active Application Filing
- 2007-12-11 KR KR1020097014549A patent/KR20090103916A/ko not_active Application Discontinuation
- 2007-12-11 JP JP2009541327A patent/JP2010513274A/ja active Pending
- 2007-12-11 CN CNA2007800451998A patent/CN101547918A/zh active Pending
- 2007-12-12 CL CL200703613A patent/CL2007003613A1/es unknown
- 2007-12-12 PE PE2007001778A patent/PE20081382A1/es not_active Application Discontinuation
- 2007-12-12 AR ARP070105570A patent/AR064306A1/es unknown
-
2009
- 2009-06-08 TN TNP2009000236A patent/TN2009000236A1/fr unknown
- 2009-06-12 DO DO2009000139A patent/DOP2009000139A/es unknown
- 2009-07-10 NO NO20092638A patent/NO20092638L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20092638L (no) | 2009-09-11 |
WO2008076247A3 (en) | 2009-01-15 |
PE20081382A1 (es) | 2008-09-18 |
KR20090103916A (ko) | 2009-10-01 |
EA200900808A1 (ru) | 2009-12-30 |
ZA200904479B (en) | 2010-09-29 |
EP2121665A2 (en) | 2009-11-25 |
TN2009000236A1 (en) | 2010-10-18 |
CN101547918A (zh) | 2009-09-30 |
EP2121665B1 (en) | 2014-01-22 |
AU2007334522B2 (en) | 2012-03-15 |
WO2008076247A2 (en) | 2008-06-26 |
JP2010513274A (ja) | 2010-04-30 |
US7880014B2 (en) | 2011-02-01 |
WO2008076246A2 (en) | 2008-06-26 |
CA2671673A1 (en) | 2008-06-26 |
AU2007334522A1 (en) | 2008-06-26 |
CL2007003613A1 (es) | 2008-07-11 |
US20100152259A1 (en) | 2010-06-17 |
WO2008076246A3 (en) | 2009-01-15 |
DOP2009000139A (es) | 2009-08-31 |
TW200831079A (en) | 2008-08-01 |
MX2009006210A (es) | 2009-07-22 |
US20080194660A1 (en) | 2008-08-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |